Thorsten Kessler
A5012230783- Genetic Associations and Epidemiology
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- RNA modifications and cancer
- Cardiac Fibrosis and Remodeling
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Phosphodiesterase function and regulation
- Infective Endocarditis Diagnosis and Management
- Nuclear Receptors and Signaling
- Renin-Angiotensin System Studies
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- Bioinformatics and Genomic Networks
- Cardiovascular Disease and Adiposity
- Nitric Oxide and Endothelin Effects
- Signaling Pathways in Disease
Deutsches Herzzentrum München
2016-2025
German Centre for Cardiovascular Research
2016-2025
Technical University of Munich
2016-2025
University of California, Los Angeles
2017-2022
University of Münster
1994-2022
München Klinik
2014-2021
ORCID
2021
Deutsches Herzzentrum der Charité
2014-2017
University of Lübeck
2011-2017
University of Tartu
2017
Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity Niemann-Pick C1-like 1 (NPC1L1) protein. However, whether such inhibition reduces risk coronary heart disease is not known. Human mutations that inactivate a gene encoding drug target can mimic action an inhibitory and thus be used to infer potential effects drug.We sequenced exons NPC1L1 in 7364 patients with 14,728 controls without who were European, African, or South Asian ancestry. We...
Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD show pleiotropy; that is, they are also other diseases or traits. This study sought to systematically test if genetic variants for non-CAD diseases/traits associate and undertake a comprehensive analysis the extent pleiotropy all loci. In discovery analyses involving 42,335 cases 78,240 control subjects we tested 29,383 common (minor allele frequency >5%) single...
<h3>Importance</h3> The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyceride-rich lipoproteins from circulation. Mutations that damage LPL gene (<i>LPL</i>) lead to lifelong deficiency enzymatic and can provide insight into relationship human disease. <h3>Objective</h3> To determine whether rare and/or common variants in<i>LPL</i>are associated with early-onset coronary artery disease (CAD). <h3>Design, Setting, Participants</h3> In a cross-sectional...
Heart failure following myocardial infarction (MI) remains one of the major causes death worldwide, and its treatment is a crucial challenge cardiovascular medicine. An attractive therapeutic strategy to stimulate endogenous mechanisms regeneration. This study evaluates potential with annexin A1 (AnxA1) induce cardiac repair after MI. AnxA1 knockout (AnxA1−/−) wild-type mice underwent MI induced by ligation left anterior descending coronary artery. Cardiac functionality was assessed...
Abstract Aims The best interventional strategy for the treatment of drug-eluting stent (DES) in-stent restenosis (ISR) is still unclear and no data from randomized trials beyond 3-year follow-up are available. We aimed to define 10-year comparative efficacy safety plain balloon (PB), paclitaxel-coated (PCB), paclitaxel-eluting (PES) percutaneous coronary intervention (PCI) DES-ISR. Methods results Clinical patients randomly assigned PB, PCB, PES in ISAR-DESIRE 3 trial was extended 10 years...
Background— ADAMTS-7, a member of the disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, was recently identified to be significantly associated genomewide coronary artery disease. However, mechanisms that link ADAMTS-7 disease risk remain elusive. We have previously demonstrated promotes vascular smooth muscle cell migration postinjury neointima formation via degradation matrix protein cartilage oligomeric protein. Because delayed endothelium repair renders...
To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition IL-1, a master regulator inflammation. We created score combining the alleles two common (rs6743376 rs1542176) are located upstream IL1RN, gene encoding IL-1 receptor antagonist (IL-1Ra; an endogenous inhibitor both IL-1α IL-1β); increase soluble IL-1Ra protein concentration. compared on inflammation biomarkers this with...
Background: A chromosomal locus at 4q32.1 has been genome-wide significantly associated with coronary artery disease risk. The encompasses GUCY1A3 , which encodes the α 1 subunit of soluble guanylyl cyclase (sGC), a key enzyme in nitric oxide/cGMP signaling pathway. mechanism linking common variants this region risk is not known. Methods: Gene expression and protein were analyzed quantitative polymerase chain reaction immunoblotting, respectively. Putative allele-specific transcription...
Abstract Aims Mental stress substantially contributes to the initiation and progression of human disease, including cardiovascular conditions. We aim investigate underlying mechanisms these contributions since they remain largely unclear. Methods results Here, we show in humans mice that leucocytes deplete rapidly from blood after a single episode acute mental stress. Using cell-tracking experiments animal models stress, found exposure leads prompt uptake inflammatory distinct tissues heart,...
Abstract Aims Targeting vascular inflammation represents a novel therapeutic approach to reduce complications of atherosclerosis. Neutralizing the pro-inflammatory cytokine interleukin-1β (IL-1β) using canakinumab, monoclonal antibody, reduces incidence cardiovascular events in patients after myocardial infarction (MI). The biological basis for these beneficial effects remains incompletely understood. We sought explore mechanisms IL-1β-targeted therapies. Methods and results In mice with...
The majority of risk loci identified by genome-wide association studies (GWAS) are in non-coding regions, hampering their functional interpretation. Instead, transcriptome-wide (TWAS) identify gene-trait associations, which can be used to prioritize candidate genes disease-relevant tissue(s). Here, we aimed systematically susceptibility for coronary artery disease (CAD) TWAS. We trained prediction models nine CAD-relevant tissues using EpiXcan based on two genetics-of-gene-expression panels,...