A5023520945- Advancements in Battery Materials
- Prostate Cancer Treatment and Research
- Advanced Battery Materials and Technologies
- Infrastructure Maintenance and Monitoring
- Protein Degradation and Inhibitors
- Asphalt Pavement Performance Evaluation
- COVID-19 Clinical Research Studies
- Peptidase Inhibition and Analysis
- Atherosclerosis and Cardiovascular Diseases
- Glycosylation and Glycoproteins Research
- Supercapacitor Materials and Fabrication
- Radiopharmaceutical Chemistry and Applications
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- SARS-CoV-2 and COVID-19 Research
- Tissue Engineering and Regenerative Medicine
- Advanced Breast Cancer Therapies
- Geotechnical Engineering and Underground Structures
- Pancreatic function and diabetes
- COVID-19 diagnosis using AI
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Case Reports on Hematomas
- Extraction and Separation Processes
- Cardiac Structural Anomalies and Repair
Harbin Institute of Technology
2022-2024
South China Agricultural University
2023-2024
Deutsches Herzzentrum München
2017-2024
Technical University of Munich
2017-2024
Dalian University
2023-2024
Dalian University of Technology
2023-2024
Ganzhou People's Hospital
2023
Aero Engine Corporation of China (China)
2023
Southwest Medical University
2022
The Sixth People's Hospital of Shenyang
2008-2021
The risk of early recurrent events after stroke remains high despite currently established secondary prevention strategies1. Risk is particularly in patients with atherosclerosis, more than 10% experiencing events1,2. However, the enormous medical burden this clinical phenomenon, underlying mechanisms leading to increased vascular and are largely unknown. Here, using a novel mouse model stroke-induced ischaemia, we show that leads activation AIM2 inflammasome vulnerable atherosclerotic...
Obesity and stress inhibit insulin action by activating protein kinases that enhance serine phosphorylation of IRS1 have been thus associated to resistance the development type II diabetes. The kinase C θ (PKCθ) is activated free-fatty acids, its activity higher in muscle from obese diabetic patients. However, a molecular link between PKCθ has not defined yet. Here we show phosphorylates at 1101 blocking tyrosine downstream activation Akt pathway. Mutation Ser1101 alanine makes insensitive...
Abstract Aims Targeting vascular inflammation represents a novel therapeutic approach to reduce complications of atherosclerosis. Neutralizing the pro-inflammatory cytokine interleukin-1β (IL-1β) using canakinumab, monoclonal antibody, reduces incidence cardiovascular events in patients after myocardial infarction (MI). The biological basis for these beneficial effects remains incompletely understood. We sought explore mechanisms IL-1β-targeted therapies. Methods and results In mice with...
Protein phosphorylation and specific protein kinases can initiate signal transduction pathways leading to programmed cell death. The phosphatases regulating apoptosis have been more elusive. Using double-stranded RNA-mediated interference (RNAi), the role of phosphatase 2A (PP2A) in cellular signaling was investigated. Knockdown A or C subunits individually combined B led concurrent loss nontargeted PP2A subunits, suggesting that is an obligate heterotrimer vivo. Global knockdown activity...
Inflammation strongly contributes to atherosclerosis initiation and progression. Consequently, recent clinical trials pharmacologically targeted vascular inflammation decrease the incidence of atherosclerosis-related complications. Colchicine, a microtubule inhibitor with anti-inflammatory properties, reduced cardiovascular events in patients acute coronary syndrome chronic disease. However, biological basis these observations remains elusive. We sought explore mechanism by which colchicine...
Protein phosphatase 2A (PP2A) is an abundant heterotrimeric serine/threonine containing highly conserved structural (A) and catalytic (C) subunits. Its diverse functions in the cell are determined by its association with a variable regulatory targeting B subunit. At least three distinct gene families encoding subunits known: B/B55/CDC55, B'/B56/RTS1 B"/PR72/130. No homology has been identified among families, little known about how these interact PP2A A C In vitro expression of series...
To investigate factors affecting effects of ultrasound guided high intensity focused (USgHIFU) in the treatment single uterine fibroids (UFs) with different magnetic resonance imaging (MRI) features.A total 207 patients symptomatic UFs who were treated HIFU retrospectively analyzed. All grouped according to MRI features, and ablation set as independent variables. Non-perfusion volume ratio (NPVR) energy efficiency factor (EEF) dependent variables establish multiple linear regression models a...
Hypoglycemia is commonly associated with insulin therapy, limiting both its safety and efficacy. The concept of modifying to render glucose-responsive release from an injection depot (of complexed exogenously a recombinant lectin) was proposed approximately 4 decades ago but has been challenging achieve. Data presented here demonstrate that mannosylated analogs can undergo additional route clearance as result their interaction endogenous mannose receptor (MR), this occur in glucose-dependent...
ABSTRACT Engineered heart tissue (EHT) transplantation represents an innovative, regenerative approach for failure patients. Late preclinical trials are underway, and a first clinical trial started recently. Preceding studies revealed functional recovery after implantation of in vitro-matured EHT the subacute stage, whereas chronic injury setting was less efficient. When transplanting matured EHTs, we noticed that cardiomyocytes undergo dedifferentiation step before eventually forming...
Abstract Functional polymer microspheres have broad application prospects in various fields, such as metal ion detection, adsorption, separation, and controlled drug release. However, integrating different functions a single microsphere system is significant challenge this field. In work, we prepared multicompartmental emulsion droplets utilizing microfluidic technology. Fe 3 O 4 magnetic nanoparticles were added to one of the compartments functional particles, Janus obtained after curing....
Generally, the conventional rejuvenator contains many mineral oils to supply missing components of aged bitumen. The could recover performance bitumen go through a long-term aging process. However, are easy volatilize at higher recycling temperature. volatilization will reduce effect and limit proportion reclaimed asphalt pavement (RAP) in recycled mixture (RAP contents less than 30%). main vegetable oil straight chain fatty acids glycerides. esters glycerol not volatile high Therefore, they...