Karl‐Ludwig Laugwitz
A5091776005- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Congenital heart defects research
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Cardiac electrophysiology and arrhythmias
- Pluripotent Stem Cells Research
- Vascular Procedures and Complications
- CRISPR and Genetic Engineering
- Tissue Engineering and Regenerative Medicine
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- Platelet Disorders and Treatments
- Neuroscience and Neural Engineering
- Cardiac Fibrosis and Remodeling
- Lipoproteins and Cardiovascular Health
- Congenital Heart Disease Studies
- Advanced MRI Techniques and Applications
- Pulmonary Hypertension Research and Treatments
Technical University of Munich
2016-2025
Klinikum rechts der Isar
2016-2025
German Centre for Cardiovascular Research
2016-2025
Ludwig-Maximilians-Universität München
2007-2025
Universität Hamburg
2025
University Medical Center Hamburg-Eppendorf
2025
München Klinik
2025
LMU Klinikum
2018-2025
Schön Klinik Bad Aibling
2025
Deutsches Herzzentrum München
2009-2024
Long-QT syndromes are heritable diseases associated with prolongation of the QT interval on an electrocardiogram and a high risk sudden cardiac death due to ventricular tachyarrhythmia. In long-QT syndrome type 1, mutations occur in KCNQ1 gene, which encodes repolarizing potassium channel mediating delayed rectifier IKs current.
Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity Niemann-Pick C1-like 1 (NPC1L1) protein. However, whether such inhibition reduces risk coronary heart disease is not known. Human mutations that inactivate a gene encoding drug target can mimic action an inhibitory and thus be used to infer potential effects drug.We sequenced exons NPC1L1 in 7364 patients with 14,728 controls without who were European, African, or South Asian ancestry. We...
Systematic investigation of restenosis after percutaneous coronary intervention (PCI) with bare metal stents (BMS) or first second generation drug eluting (DES) in large scale, broadly inclusive patient populations undergoing follow-up angiography represents a gap our scientific knowledge. We investigated the incidence angiographically proven and its predictors patients PCI stents.All successful implantation for de novo lesions from 1998 to 2009 at 6-8 months two centres Munich, Germany were...
The combination of glycoprotein IIb/IIIa inhibitors and heparin has not been compared with bivalirudin in studies specifically involving patients non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention (PCI). We the two treatments this patient population.Immediately before PCI, we randomly assigned, a double-blind manner, 1721 acute to receive abciximab plus unfractionated (861 patients) or (860 patients). study tested hypothesis that would be superior...
Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD show pleiotropy; that is, they are also other diseases or traits. This study sought to systematically test if genetic variants for non-CAD diseases/traits associate and undertake a comprehensive analysis the extent pleiotropy all loci. In discovery analyses involving 42,335 cases 78,240 control subjects we tested 29,383 common (minor allele frequency >5%) single...
Background— The Bleeding Academic Research Consortium (BARC) has recently proposed a unified definition of bleeding in patients receiving antithrombotic therapy. We investigated the relationship between events as defined by BARC and 1-year mortality undergoing percutaneous coronary intervention (PCI) assessed whether is superior to existing definitions regard prediction after PCI procedures. Methods Results— This study represents patient-level pooled analysis 12 459 recruited 6 randomized...
In patients with ST-segment elevation myocardial infarction (STEMI) multivessel coronary artery disease, the time at which complete revascularization of nonculprit lesions should be performed remains unknown. Download a PDF Research Summary. We an international, open-label, randomized, noninferiority trial 37 sites in Europe. Patients hemodynamically stable condition who had STEMI and disease were randomly assigned to undergo immediate percutaneous intervention (PCI; group) or PCI culprit...
Abstract Aims The best interventional strategy for the treatment of drug-eluting stent (DES) in-stent restenosis (ISR) is still unclear and no data from randomized trials beyond 3-year follow-up are available. We aimed to define 10-year comparative efficacy safety plain balloon (PB), paclitaxel-coated (PCB), paclitaxel-eluting (PES) percutaneous coronary intervention (PCI) DES-ISR. Methods results Clinical patients randomly assigned PB, PCB, PES in ISAR-DESIRE 3 trial was extended 10 years...
Abstract The epicardium, the mesothelial envelope of vertebrate heart, is source multiple cardiac cell lineages during embryonic development and provides signals that are essential to myocardial growth repair. Here we generate self-organizing human pluripotent stem cell-derived epicardioids display retinoic acid-dependent morphological, molecular functional patterning epicardium myocardium typical left ventricular wall. By combining lineage tracing, single-cell transcriptomics chromatin...
Abstract Background and Aims Risk stratification for mitral valve transcatheter edge-to-edge repair (M-TEER) is paramount in the decision-making process to appropriately select patients with severe secondary regurgitation (SMR). This study sought develop validate an artificial intelligence-derived risk score (EuroSMR score) predict 1-year outcomes (survival or survival + clinical improvement) SMR undergoing M-TEER. Methods An was developed from EuroSMR cohort (4172 428 treated M-TEER...
Background —Platelet/endothelium interaction plays an important role in the pathophysiology of inflammation and atherosclerosis. The platelets for monocyte chemotactic protein-1 (MCP-1) secretion surface expression intercellular adhesion molecule-1 (ICAM-1) on endothelial cells has been assessed. Methods Results —Monolayers human umbilical vein were incubated with nonstimulated or ADP-activated 6 hours, MCP-1 ICAM-1 determined by ELISA flow cytometry, respectively. In presence platelets,...
Although biodegradable polymer drug-eluting stent (DES) platforms have potential to enhance long-term clinical outcomes, data concerning their efficacy are limited date. We previously demonstrated angiographic antirestenotic with a microporous, DES. In the current study, we hypothesized that at 12 months, its safety and would be non-inferior of permanent This prospective, randomized, open-label, active-controlled trial was conducted two tertiary referral cardiology centres in Munich,...
The role of vascular closure devices (VCD) for the achievement hemostasis in patients undergoing transfemoral coronary angiography remains controversial.To compare outcomes with use 2 strategies after diagnostic performed via access-a VCD-based strategy types devices, an intravascular device and extravascular device, vs standard manual compression. primary hypothesis to be tested was that femoral achieved through VCD is noninferior compression terms access-site complications. A secondary...