A5068145002- Adipokines, Inflammation, and Metabolic Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Atherosclerosis and Cardiovascular Diseases
Deutsches Herzzentrum München
2018-2021
German Centre for Cardiovascular Research
2021
Zimmerman Associates (United States)
2018
Abstract Aims Mental stress substantially contributes to the initiation and progression of human disease, including cardiovascular conditions. We aim investigate underlying mechanisms these contributions since they remain largely unclear. Methods results Here, we show in humans mice that leucocytes deplete rapidly from blood after a single episode acute mental stress. Using cell-tracking experiments animal models stress, found exposure leads prompt uptake inflammatory distinct tissues heart,...
Introduction: The genomic locus harboring the GUCY1A3 gene has been associated with coronary artery disease (CAD) risk variant reducing expression via allele-specific transcription factor binding. encodes alpha 1 -subunit of soluble guanylyl cyclase (sGC) which produces second messenger cyclic guanosine monophosphate (cGMP) upon activation by nitric oxide, thereby influencing function vascular smooth muscle cells and platelets. Aim: To investigate whether a reduction in sGC specifically...