A5001323846- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Genetics and Plant Breeding
- Liver Disease Diagnosis and Treatment
- Genomics and Rare Diseases
- Clostridium difficile and Clostridium perfringens research
- Pancreatitis Pathology and Treatment
- Parasites and Host Interactions
- Chemokine receptors and signaling
- Genetic Syndromes and Imprinting
- Bone health and treatments
- Nutrition, Genetics, and Disease
- Genomic variations and chromosomal abnormalities
- Viral gastroenteritis research and epidemiology
- Bioinformatics and Genomic Networks
- Lipoproteins and Cardiovascular Health
- Risk and Safety Analysis
Shaoxing People's Hospital
2024
Boston University
2015-2023
The University of Texas Health Science Center at Houston
2020
Brown University
2015
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes
(18)F-fluoride PET quantitatively images bone metabolism and may serve as a pharmacodynamic assessment for systemic therapy such dasatinib, potent SRC kinase inhibitor, with activity in bone. This was an imaging companion trial (American College of Radiology Imaging Network [ACRIN] 6687) to multicenter metastatic castration-resistant prostate cancer (CRPC) tissue biomarker-guided therapeutic (NCT00918385). Men CRPC underwent before 12 weeks after initiation dasatinib (100 mg daily). Dynamic...
ABSTRACT Common SNPs are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here we show, using GWAS data from 5.4 million individuals diverse ancestries, that 12,111 independent significantly with height account for nearly all common SNP-based heritability. These clustered within 7,209 non-overlapping genomic segments a median size ~90 kb, covering ~21% genome. The density...
In studies with multi-omics data available, there is an opportunity to investigate interdependent mechanisms of biological causality. The GAW20 set includes both DNA genotype and methylation measures before after fenofibrate treatment. Using change in triglyceride (TG) levels pre- posttreatment as outcome, we present a mediation analysis that incorporates methylation. This approach allows us simultaneously consider hypothesis affects TG level by means its effect on methylation, interaction...
Psychological and social factors are known to influence blood pressure (BP) risk of hypertension associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses systolic, diastolic, pulse, mean arterial BP, taking into account the interaction effects genetic variants with three psychosocial factors: depressive symptoms, anxiety support. Analyses were performed using a two-stage design in sample up 128,894 adults from five ancestry groups....
Genome-wide association studies often collect multiple phenotypes for complex diseases. Multivariate joint analyses have higher power to detect genetic variants compared with the marginal analysis of each phenotype and are also able identify loci pleiotropic effects. We extend unified score-based test incorporate family structure, apply different approaches analyze traits in GAW20 real samples, compare results. Through simulation studies, we confirm that Type I error rate pedigree-based...
Recent focus on studying rare variants makes imputation accuracy of an important issue. Many approaches have been proposed to increase among variants, from reference panel selection combinations existing methods multistage analyses. We aimed bring the strengths these new together with our two-stage for family data.Our were tested region 46.75Mb 49.25Mb chromosome 3. did quality control based proportion missing genotypes per variant and individual, leaving 495 individuals 761 genome-wide...
Abstract Genome-Wide Association (GWA) with population-based imputation (PBI) has been successful in identifying common variants associated complex diseases; however, much heritability remains to be explained and low frequency (LFV) may contribute. To identify LFV, a study of unrelated individuals no longer as efficient family study, where rare population can frequent families. Family-based (FBI) provides an opportunity evaluate LFV. compare the performance PBI FBI, we conducted extensive...
Emerging data from paediatric populations suggest that variants in the autophagy-governing immunity-related GTPase M (IRGM) gene may contribute to nonalcoholic fatty liver disease (NAFLD) susceptibility. We examined relationship between IRGM rs13361189 and NAFLD a community-based cohort of adults.We included all Framingham Heart Study participants with available on variant, undergoing study-directed computed tomography (CT) scans abdomen (2002-2005). Using multivariable linear logistic...
Anthropometric traits, measuring body size and shape, are highly heritable significant clinical risk factors for cardiometabolic disorders. These traits have been extensively studied in genome-wide association studies (GWASs), with hundreds of loci identified. We performed a whole-exome sequence analysis the genetics height, mass index (BMI) waist/hip ratio (WHR). meta-analyzed single-variant gene-based associations variation BMI, WHR up to 22,004 individuals, we assessed replication our...