A5102756357- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Bone health and osteoporosis research
- Pulmonary Hypertension Research and Treatments
- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Fatty Acid Research and Health
- Neonatal Respiratory Health Research
- Delphi Technique in Research
- Pediatric health and respiratory diseases
- Obesity, Physical Activity, Diet
- Hip and Femur Fractures
- Crystallization and Solubility Studies
- Lung Cancer Treatments and Mutations
- X-ray Diffraction in Crystallography
- Genetic Syndromes and Imprinting
- Genetic Mapping and Diversity in Plants and Animals
- Nutrition and Health in Aging
- Liver Diseases and Immunity
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
Boston University
2017-2025
Xi’an Jiaotong-Liverpool University
2024
Cancer Research And Biostatistics
2022
Georgetown University
2017-2018
Georgetown University Medical Center
2017-2018
Hefei University of Technology
2016
Zhejiang University
2008
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the that believed to result from an atypical response injury epithelium. Genome-wide association studies have reported signals implicating multiple pathways including host defense, telomere maintenance, signaling, and cell-cell adhesion.Objectives: To improve our understanding factors increase IPF susceptibility identifying previously unreported genetic associations.Methods: We conducted...
ABSTRACT Older adults with type 2 diabetes (T2D) tend to have normal or greater areal bone mineral density (aBMD), as measured by DXA, than those who do not (non-T2D). Yet risk of fracture is higher in T2D, including 40% 50% increased hip risk. We used HR-pQCT investigate structural mechanisms underlying skeletal fragility T2D. compared cortical and trabecular microarchitecture, density, area, strength T2D non-T2D. In secondary analyses we evaluated whether associations between measures...
<h3>Importance</h3> Many studies of the association between obesity and mortality rely on weight status at a single point in time, making it difficult to adequately address bias associated with reverse causality. <h3>Objective</h3> To investigate maximum body mass index (BMI) all-cause without consequences <h3>Design, Setting, Participants</h3> Prospective cohort for original offspring cohorts Framingham Heart Study. The follow-up period started from baseline examination 13 6 ended December...
Rationale: Interstitial lung abnormalities (ILAs) are associated with the highest genetic risk locus for idiopathic pulmonary fibrosis (IPF); however, extent to which there unique associations among individuals ILAs or additional overlap IPF is not known.Objectives: To perform a genome-wide association study (GWAS) of ILAs.Methods: and subpleural-predominant subtype were assessed on chest computed tomography (CT) scans in AGES (Age Gene/Environment Susceptibility), COPDGene (Genetic...
Background and Aims NAFLD is increasing in prevalence will soon be the most common chronic liver disease. Liver stiffness, as assessed by vibration‐controlled transient elastography (VCTE), correlates with hepatic fibrosis, an important predictor of liver‐related all‐cause mortality. Although fat associated cardiovascular risk factors, association between fibrosis factors less clear. Approach Results We performed VCTE, assessing controlled attenuation parameter (CAP; measure steatosis)...
Rationale: In addition to rare genetic variants and the MUC5B locus, common contribute idiopathic pulmonary fibrosis (IPF) risk. The predictive power of outside locus for IPF interstitial lung abnormalities (ILAs) is unknown. Objectives: We tested value polygenic risk scores (PRSs) with without region on IPF, ILA, ILA progression. Methods: developed PRSs that included (PRS-M5B) excluded (PRS-NO-M5B) (500-kb window around rs35705950-T) using an genome-wide association study. assessed PRS...
The association between aging and idiopathic pulmonary fibrosis has been established. associations aging-related biomarkers interstitial lung abnormalities (ILA) have not comprehensively evaluated.
Osteoporosis, a disease characterized by low bone mineral density (BMD), increases the risk for fractures. Conventional factors alone do not completely explain measured BMD or osteoporotic fracture risk. Metabolomics may provide additional information. We aim to identify BMD-associated metabolomic markers that are predictive of assessed 209 plasma metabolites liquid chromatography with tandem mass spectrometry (LC-MS/MS) in 1552 Framingham Offspring Study participants, and femoral neck (FN)...
Inflammation contributes to lung function decline and the development of chronic obstructive pulmonary disease. Omega-3 fatty acids have antiinflammatory properties may benefit health.
Abstract Triple-negative breast cancer (TNBC) is traditionally considered a glycolytic tumor with poor prognosis while lacking targeted therapies. Here we show that high expression of dihydrolipoamide S-succinyltransferase (DLST), tricarboxylic acid (TCA) cycle enzyme, predicts overall and recurrence-free survival among TNBC patients. DLST depletion suppresses growth induces death in subsets human cell lines, which are capable utilizing glutamine anaplerosis. Metabolomics profiling reveals...
Abstract Introduction Observational studies have shown that body mass index (BMI) and waist‐to‐hip ratio (WHR) are both inversely associated with lung function, as assessed by forced vital capacity (FVC) expiratory volume in 1 s (FEV1). However, observational data susceptible to confounding reverse causation. Methods We selected genetic instruments based on their relevant large‐scale genome‐wide association studies. Summary statistics of function asthma came from the UK Biobank SpiroMeta...
Summary Background Adiposity amplifies the genetic risk of non‐alcoholic fatty liver disease (NAFLD). Aim We evaluated association between overweight‐years, a cumulative exposure based on product duration and severity excess body weight (body mass index (BMI) ≥ 25 kg/m 2 ), fat fibrosis. Methods This is longitudinal analysis derived from prospective cohort adults in Framingham Heart Study who underwent genotyping vibration‐controlled‐transient‐elastography with controlled attenuation...
Body mass index (BMI) is associated with chronic obstructive pulmonary disease (COPD) mortality, but the underlying mechanisms are unclear. The effect of genetic variants aggregated into a polygenic score may elucidate causal and predict risk.
Importance Chronic obstructive pulmonary disease (COPD) is often undiagnosed. Although genetic risk plays a significant role in COPD susceptibility, its utility guiding spirometry testing and identifying undiagnosed cases unclear. Objective To determine whether polygenic score (PRS) enhances the identification of beyond case-finding questionnaire (eg, Lung Function Questionnaire) using conventional factors respiratory symptoms. Design, Setting, Participants This cross-sectional analysis...
Background Genetic susceptibility may be associated with earlier onset of chronic obstructive pulmonary disease (COPD). We hypothesised that a polygenic risk score (PRS) for COPD would age diagnosis COPD. Methods In 6647 non-Hispanic White (NHW) and 2464 African American (AA) participants from COPDGene, 6812 the Framingham Heart Study (FHS), we tested relationship PRS diagnosis. Age at was determined by: 1) self-reported or 2) visits when moderate-to-severe airflow limitation (Global...
Rationale: There is increasing evidence that aberrant processes occurring in the airways may precede development of idiopathic pulmonary fibrosis (IPF); however, there has been no prior confirmatory data derived from imaging studies.Objectives: To assess quantitative measures airway wall thickness (AWT) populations characterized for interstitial lung abnormalities (ILA) and IPF.Methods: Computed tomographic chest AWT were available 6,073, 615, 1,167, 38 participants COPDGene (Genetic...
ABSTRACT Weight loss in older adults is associated with increased bone and fracture. Little known about the potential impact of weight on cortical trabecular density, microarchitecture, strength. In this study, participants were members Framingham Offspring Cohort (769 women, 595 men; mean age 70 ± 8 years), who underwent high-resolution peripheral quantitative computed tomography (HR-pQCT) scanning at tibia radius 2012 to 2016. measurements taken every 4 6 years used assess recent change...