David J. Lederer
A5050993312- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Pulmonary Hypertension Research and Treatments
- Renal Transplantation Outcomes and Treatments
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Occupational and environmental lung diseases
- Inhalation and Respiratory Drug Delivery
- MicroRNA in disease regulation
- Systemic Sclerosis and Related Diseases
- Frailty in Older Adults
- Occupational exposure and asthma
- Cancer-related molecular mechanisms research
- Pneumonia and Respiratory Infections
- Nutrition and Health in Aging
- Respiratory viral infections research
Regeneron (United States)
2019-2024
Columbia University Irving Medical Center
2014-2023
Sanofi (United States)
2023
Nationwide Children's Hospital
2023
Columbia University
2012-2021
Royal Prince Alfred Hospital
2021
Pulmonary Fibrosis Foundation
2016-2021
Mental Health Association of Westchester County
2021
The Ocean Cleanup
2021
National and Kapodistrian University of Athens
2021
In two of three phase 3 trials, pirfenidone, an oral antifibrotic therapy, reduced disease progression, as measured by the decline in forced vital capacity (FVC) or capacity, patients with idiopathic pulmonary fibrosis; third trial, this end point was not achieved. We sought to confirm beneficial effect pirfenidone on progression such patients.In study, we randomly assigned 555 fibrosis receive either (2403 mg per day) placebo for 52 weeks. The primary change FVC death at week 52. Secondary...
This document provides clinical recommendations for the diagnosis of idiopathic pulmonary fibrosis (IPF). It represents a collaborative effort between American Thoracic Society, European Respiratory Japanese and Latin Society.The evidence syntheses were discussed formulated by multidisciplinary committee IPF experts. The was appraised formulated, written, graded using Grading Recommendations, Assessment, Development, Evaluation approach.The guideline panel updated diagnostic criteria IPF....
Section:ChooseTop of pageAbstract <<ContentsSummary Recommendation...IntroductionHow to Use These Guidelin...MethodsDefinitionClinical ManifestationsPathogenesisRadiological FeaturesHistopathological Feature...Diagnostic CriteriaDiagnostic InterventionsFuture DirectionsConclusionsReferencesCITING ARTICLES
Key Principle #1: Causal inference requires careful consideration of confounding d Preferred variable selection methods 1. Historical confounder definition with purposeful 2. models using directed acyclic graphs Variable that do not adequately control for 3. P value-or model-based 4. Methods based on b-coefficient changes 5. Selection variables to identify "independent predictors" Do present all the effect estimates from a model designed test single causal association (Table 2 fallacy) #2:...
Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors.We sought to identify donor, recipient, perioperative factors PGD.We performed a 10-center prospective cohort study enrolled between March 2002 December 2010 (the Lung Transplant Outcomes Group). The primary outcome was International Society Heart Transplantation grade 3 at 48 or 72 hours post-transplant....
Chinese translation This article has been corrected. The original version (PDF) is appended to this as a Supplement. Background: Idiopathic pulmonary fibrosis (IPF) characterized by formation and proliferation of fibroblast foci. Endothelin-1 induces lung contractile activity via the endothelin A (ETA) receptor. Objective: To determine whether ambrisentan, an ETA receptor–selective antagonist, reduces rate IPF progression. Design: Randomized, double-blind, placebo-controlled, event-driven...
Background— Right ventricular failure from increased pulmonary vascular loading is a major cause of morbidity and mortality, yet its modulation by disease remains poorly understood. We tested the hypotheses that, unlike systemic circulation, resistance (R PA ) compliance (C are consistently inversely related regardless age, hypertension, or interstitial fibrosis that this relation may be changed elevated capillary wedge pressure, augmenting right pulsatile load. Methods Results— Several...
Functional studies may be useful to predict survival in idiopathic pulmonary fibrosis (IPF). Various cutoffs of 6-min-walk distance (6MWD) have been suggested identify patients at a high risk death.
<h3>Importance</h3> While air pollutants at historical levels have been associated with cardiovascular and respiratory diseases, it is not known whether exposure to contemporary pollutant concentrations progression of emphysema. <h3>Objective</h3> To assess the longitudinal association ambient ozone (O<sub>3</sub>), fine particulate matter (PM<sub>2.5</sub>), oxides nitrogen (NO<sub>x</sub>), black carbon change in percent emphysema assessed via computed tomographic (CT) imaging lung...
Idiopathic pulmonary fibrosis is often initially misdiagnosed. Delays in accessing subspecialty care could lead to worse outcomes among those with idiopathic fibrosis.
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the that believed to result from an atypical response injury epithelium. Genome-wide association studies have reported signals implicating multiple pathways including host defense, telomere maintenance, signaling, and cell-cell adhesion.Objectives: To improve our understanding factors increase IPF susceptibility identifying previously unreported genetic associations.Methods: We conducted...
Human tissue-resident memory T cells persist long term in transplanted lungs and develop from infiltrating recipient cells.
Prediction models aim to use available data predict a health state or outcome that has not yet been observed. is primarily relevant clinical practice, but also used in research, and administration. While prediction modeling involves estimating the relationship between patient factors outcomes, it distinct from casual inference. thus requires unique considerations for development, validation, updating. This document represents an effort editors at 31 respiratory, sleep, critical care medicine...
Rationale: Current diagnosis of chronic hypersensitivity pneumonitis (cHP) involves considering a combination clinical, radiological, and pathological information in multidisciplinary team discussions. However, this approach is highly variable with poor agreement between centers.Objectives: We aimed to identify diagnostic criteria for cHP that reach consensus among international experts.Methods: A three-round modified Delphi survey was conducted April August 2017. total 45 experts...
Evidence-based guidelines are needed for effective delivery of home oxygen therapy to appropriate patients with chronic obstructive pulmonary disease (COPD) and interstitial lung (ILD).
The pathogenesis of idiopathic pulmonary fibrosis (IPF), an intractable interstitial lung disease, is unclear. Recessive mutations in some genes implicated Hermansky-Pudlak syndrome (HPS) cause HPS-associated pneumonia (HPSIP), a clinical entity that similar to IPF. We previously reported HPS1−/− embryonic stem cell-derived 3D organoids showed fibrotic changes. Here, we show the introduction all HPS associated with HPSIP promotes changes organoids, while deletion HPS8, which not HPSIP, does...
Frailty is associated with morbidity and mortality in abdominal organ transplantation but has not been examined lung transplantation.To examine the construct predictive validity of frailty phenotypes transplant candidates.In a multicenter prospective cohort, we measured Fried Phenotype (FFP) Short Physical Performance Battery (SPPB). We evaluated through comparisons conceptually related factors. In nested case-control study frail nonfrail subjects, serum IL-6, tumor necrosis factor receptor...