A5077056439- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Occupational exposure and asthma
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Eosinophilic Disorders and Syndromes
- Viral Infections and Immunology Research
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Bacillus and Francisella bacterial research
- Radiomics and Machine Learning in Medical Imaging
- Polyomavirus and related diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mast cells and histamine
- Air Quality and Health Impacts
- Sinusitis and nasal conditions
- Rheumatoid Arthritis Research and Therapies
- Advanced X-ray and CT Imaging
- S100 Proteins and Annexins
- Autoimmune and Inflammatory Disorders
- Tuberculosis Research and Epidemiology
- T-cell and B-cell Immunology
- Drug-Induced Adverse Reactions
- Monoclonal and Polyclonal Antibodies Research
- Trace Elements in Health
National Jewish Health
2015-2024
University of Colorado Denver
2015-2024
Colorado School of Public Health
2015-2024
University of Colorado Anschutz Medical Campus
2015-2024
Justus-Liebig-Universität Gießen
2024
Imperial College London
2023
Royal Brompton Hospital
2023
University of Würzburg
2021-2022
Social Neuroscience Lab
2021-2022
Klinikum rechts der Isar
2019-2022
Section:ChooseTop of pageAbstract <<ContentsSummary Recommendation...IntroductionMethodsDiagnosisDiagnostic TestingConclusionsReferencesCITING ARTICLES
Section:ChooseTop of pageAbstract <<ContentsSummary Recommendation...IntroductionHow to Use These Guidelin...MethodsDefinitionClinical ManifestationsPathogenesisRadiological FeaturesHistopathological Feature...Diagnostic CriteriaDiagnostic InterventionsFuture DirectionsConclusionsReferencesCITING ARTICLES
The blood beryllium lymphocyte proliferation test is used in medical surveillance to identify both sensitization and chronic disease. Approximately 50% of individuals with have disease at the time their initial clinical evaluation; however, rate progression from unknown. We monitored a cohort beryllium-sensitized patients 2-year intervals, using bronchoalveolar lavage repeated transbronchial lung biopsies determine as evidenced by granulomatous inflammation tissue. Fifty-five were range 2 5...
The HLA class II (DRB1 and DQB1) associations with sarcoidosis have been studied by several groups but often without consistent results. In this paper, we consider the hypothesis that observed inconsistencies relate to distinct, genetically encoded disease phenotypes which differ in prevalence between centres. We therefore typed HLA-DRB1 DQB1 340 UK, 139 Dutch 163 Japanese patients and, respectively, 354, 218 168 healthy controls from these populations. applied phenotyping genotyping...
Rationale: Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung.Objectives: To develop an integrated understanding of located in multiple loci reported contribute risk disease.Methods: We performed deep targeted resequencing (3.69 Mb DNA) cases (n = 3,624) control subjects 4,442) across genes regions previously disease. tested for associations between disease 1) individual via logistic...
Socioeconomic factors are associated with worse disease severity at presentation in sarcoidosis, but the relative importance of socioeconomic variables on morbidity and burden has not been fully elucidated.
Chronic beryllium disease (CBD) is associated with the allelic substitution of a Glu69 in HLA-DPB1 gene. Although up to 97% CBD patients may have marker, about 30-45% beryllium-exposed, unaffected individuals carry same marker. Because occurs only 1-6% exposed workers, presence does not appear be sole genetic factor underlying development. Using two rounds direct automated DNA sequencing precisely assign haplotypes, we discovered highly significant Glu69-containing allele frequency...
Section:ChooseTop of pageAbstract <<Overview SarcoidosisOverview the Lung Micr...Rationale for GRADS S...Clinical Outcome MeasuresStudy Procedures and Samp...Study AnalysesStudy PotentialConclusionsReferencesCITING ARTICLES
Löfgren’s syndrome (LS) is an acute form of sarcoidosis characterized by a genetic association with HLA-DRB1*03 (HLA-DR3) and accumulation CD4+ T cells unknown specificity in the bronchoalveolar lavage (BAL). Here, we screened related LS-specific TCRs for antigen identified peptide derived from NAD-dependent histone deacetylase hst4 (NDPD) Aspergillus nidulans that stimulated these HLA-DR3–restricted manner. Using ELISPOT analysis, greater number IFN-γ– IL-2–secreting BAL DR3+ LS subjects...
Background Sarcoidosis is a multisystem granulomatous disease of unknown origin with variable and often unpredictable course pattern organ involvement. In this study we sought to identify specific bronchoalveolar lavage (BAL) cell gene expression patterns indicative distinct phenotypic traits. Methods RNA sequencing by Ion Torrent Proton was performed on BAL cells obtained from 215 well-characterised patients pulmonary sarcoidosis enrolled in the multicentre Genomic Research Alpha-1...
Abstract A glutamic acid at residue 69(Glu69) in the HLA-DPB1 gene (Glu69) is associated with chronic beryllium disease (CBD) and possibly sensitization (BeS). This study tested hypothesis that MHC class II polymorphisms are important susceptibility to BeS CBD Glu69 variant related markers of severity. Genomic DNA was obtained from (n = 50), 104), beryllium-exposed nondiseased (Be-nondiseased) 125) subjects. HLA-DPB1, -DRB1, -DQB1 genotypes were determined by (sequence-specific primers) PCR....
Chronic beryllium disease (CBD) is a granulomatous disorder characterized by an influx of (Be)-specific CD4+ T cells into the lung. The vast majority these recognize Be in HLA-DP–restricted manner, and peptide required for cell recognition. However, peptides that stimulate Be-specific are unknown. Using positional scanning libraries fibroblasts expressing HLA-DP2, most prevalent HLA-DP molecule linked to disease, we identified mimotopes endogenous self-peptides bind MHCII Be, forming complex...
Abstract Sarcoidosis is a complex systemic disease. Our study aimed to (1) identify novel alleles associated with sarcoidosis susceptibility; (2) provide an in-depth evaluation of HLA and susceptibility (3) integrate genetic transcription data risk loci that may more directly impact disease pathogenesis. We report genome-wide association 1335 cases 1264 controls European descent (EA) investigate in African Americans (AA: 1487 1504 controls). The EA AA cohort was recruited from multiple...