A5044464059- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Diagnosis and Treatment
- Occupational and environmental lung diseases
- Radiomics and Machine Learning in Medical Imaging
- Systemic Sclerosis and Related Diseases
- COVID-19 Clinical Research Studies
- Medical Imaging and Pathology Studies
- COVID-19 diagnosis using AI
- Ultrasound in Clinical Applications
- Long-Term Effects of COVID-19
- Pulmonary Hypertension Research and Treatments
- Pleural and Pulmonary Diseases
- Medical Imaging Techniques and Applications
- Medical and Health Sciences Research
- Lung Cancer Treatments and Mutations
- Inhalation and Respiratory Drug Delivery
- Ultrasound and Hyperthermia Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Vasculitis and related conditions
- Protein Degradation and Inhibitors
- Cancer Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Connective tissue disorders research
The Royal Free Hospital
2017-2024
University College London
2014-2024
Royal Free London NHS Foundation Trust
2017-2023
Royal Brompton Hospital
2018-2021
Royal Brompton & Harefield NHS Foundation Trust
2019-2020
Imperial College London
2020
Newcastle University
2019
Barnet Hospital
2017
University College Hospital
2014
The University of Texas MD Anderson Cancer Center
2007
Large numbers of people are being discharged from hospital following COVID-19 without assessment recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and 69% fatigue. 14.6% had depression. those with elevated biomarkers, 30.1% 9.5% persistently d-dimer C reactive protein, respectively. 38% chest radiographs remained abnormal 9% deteriorating. Systematic follow-up after hospitalisation identifies...
Rationale: Quantitative computed tomographic (CT) measures of baseline disease severity might identify patients with idiopathic pulmonary fibrosis (IPF) an increased mortality risk. We evaluated whether quantitative CT variables could act as a cohort enrichment tool in future IPF drug trials.Objectives: To determine computer-derived measures, specifically vessel–related structures (VRSs), can better predict functional decline and survival reduce requisite sample sizes trial...
The aim of this study was to compare radiology-based prediction models in rheumatoid arthritis-related interstitial lung disease (RAILD) identify patients with a progressive fibrosis phenotype.RAILD had computed tomography (CT) scans scored visually and using CALIPER forced vital capacity (FVC) measurements. Outcomes were evaluated three techniques, as follows. 1) Scleroderma system evaluating visual extent FVC values; 2) Fleischner Society idiopathic pulmonary (IPF) diagnostic guidelines...
Background Mosaic attenuation on computed tomography (CT) has been identified in international guidelines as an important diagnostic feature of fibrotic hypersensitivity pneumonitis (FHP) opposed to idiopathic pulmonary fibrosis (IPF). However, mosaic comprises several different radiological signs (low-density lobules, preserved air trapping and the so-called “headcheese sign”) which may have differing utility. Furthermore, extent required distinguish these two diagnoses is uncertain...
Rationale: Chronic hypersensitivity pneumonitis (CHP) is a condition that arises after repeated exposure and sensitization to inhaled antigens. The lung microbiome increasingly implicated in respiratory disease, but, date, no study has investigated the composition of microbial communities lower airways CHP.Objectives: To characterize compare airway subjects with CHP, idiopathic pulmonary fibrosis (IPF), control subjects.Methods: We prospectively recruited individuals CHP diagnosis (n = 110),...
AimsAutoimmune conditions such as rheumatoid arthritis-related interstitial lung disease (RA-ILD) have been linked to the existence of emphysema in never-smokers. We aimed quantify prevalence RA-ILD never-smokers and investigate whether combined pulmonary fibrosis (CPFE) results a worsened prognosis independent baseline extent.MethodsRA-ILD patients presenting Royal Brompton Hospital (n = 90) Asan Medical Center 155) had CT's evaluated for definite usual pneumonia (UIP) pattern, visual...
Increasing bacterial burden in the lower airways of patients with idiopathic pulmonary fibrosis confers an increased risk disease progression and mortality. However, it remains unclear whether this directly influences or simply reflects magnitude underlying extent severity. We prospectively recruited 193 who underwent bronchoscopy received a multidisciplinary diagnosis fibrosis. Quantification total bronchoalveolar lavage fluid was performed by 16S rRNA gene qPCR. Imaging independently...
ABSTRACT Background and objective This study evaluated whether patients with combined pulmonary fibrosis emphysema (CPFE) have an increased likelihood of hypertension (PHT) when compared idiopathic (IPF) without emphysema. Methods Two consecutive IPF populations having undergone transthoracic echocardiography were examined ( n = 223 162). Emphysema interstitial lung disease (ILD) extent quantified visually; ILD was also by a software tool, CALIPER. Echocardiographic criteria categorized PHT...
As the COVID-19 pandemic sweeps across UK there remain issues with reverse-transcription polymerase chain reaction (RT-PCR), gold standard diagnostic method. Delays in obtaining results have been particularly problematic. Some patients, including those high clinical suspicion of COVID-19, test falsely negative on initial RT-PCR test, sometimes requiring multiple subsequent tests to return an eventual positive result. Suggested possible reasons for this include: suboptimal sampling...
The prognosis of RA-associated interstitial lung disease (RA-ILD) is difficult to predict because the variable clinical course. This study aimed determine prognostic value an automated quantification system (AQS) in RA-ILD.We retrospectively analysed data and high-resolution CT (HRCT) images 144 patients with RA-ILD. Quantitative fibrosis (QLF, sum reticulation traction bronchiectasis) ILD [QILD; QLF, honeycombing (QHC), ground-glass opacity (QGG)] scores were measured using AQS.The mean age...
Patients with idiopathic pulmonary fibrosis (IPF) receiving antifibrotic medication and patients non-IPF fibrosing lung disease often demonstrate rates of annualised forced vital capacity (FVC) decline within the range measurement variation (5.0%-9.9%). We examined whether change in visual CT variables could help confirm marginal FVC declines represented genuine clinical deterioration rather than noise.In two IPF cohorts (cohort 1: n=103, cohort 2: n=108), separate pairs radiologists scored...
RA-ILD has a variable clinical course, and its prognosis is difficult to predict. Moreover, risk prediction models for remain undefined.The model was developed using retrospective data from 153 patients with validated in an independent cohort (n = 149). Candidate variables the were screened multivariate Cox proportional hazard model. C-statistics calculated assess compare predictive ability of each model.In derivation cohort, median follow-up period 54 months, 38.6% subjects exhibited UIP...
Rationale: Identifying patients with pulmonary fibrosis (PF) at risk of progression can guide management. Objectives: To explore the utility combining baseline BAL and computed tomography (CT) in differentiating progressive nonprogressive PF. Methods: The derivation cohort consisted incident cases PF for which was performed as part a diagnostic workup. A validation prospectively recruited identical inclusion criteria. Baseline thoracic CT scans were scored extent usual interstitial pneumonia...
Objectives COVID-19 studies report on hospital admission outcomes across SARS-CoV-2 waves of infection but knowledge the impact variants development Long COVID in survivors is limited. We sought to investigate outcomes, aiming compare adult hospitalised with known concern during our first and second UK waves, prior widespread vaccination. Design Prospective observational cross-sectional study. Setting Secondary care tertiary UK. Participants This study investigated 673 adults...
Abstract Background No single pulmonary function test captures the functional effect of emphysema in idiopathic fibrosis (IPF). Without experienced radiologists, other methods are needed to determine extent. Here, we report development and validation a formula predict extent patients with IPF emphysema. Methods The cohort included 76 combined at Royal Brompton Hospital, London, United Kingdom. was derived using stepwise regression generate weighted combination data that fitted best on...
Diffuse alveolar haemorrhage (DAH) is characterized by the diffuse accumulation of red blood cells within alveoli, presence ground glass opacities and/or consolidation on computed tomography (CT). Aside from identifiable non-immune causes, DAH classically subdivided into idiopathic (idiopathic pulmonary haemosiderosis, IPH) and autoimmune DAH. Here we describe three cases presenting with recurrent haemorrhage, initially classified as IPH, who, several years after first presentation, develop...
Idiopathic pulmonary fibrosis (IPF) with coexistent emphysema, termed combined and emphysema (CPFE) may associate reduced forced vital capacity (FVC) declines compared to non-CPFE IPF patients. We examined associations between mortality functional measures of disease progression in two cohorts.
Objectives: Tissue diagnosis prior to thoracic surgery with curative intent is vital in lesions concerning for lung cancer. Methods of obtaining tissue are variable within the United Kingdom.Methods: We performed a model-based analysis identify most efficient method using both health care perspective. Our concerns adults UK presenting solitary pulmonary nodule suspicious primary malignancy, patients more advanced disease (for example lymph node spread) were not considered. Model assumptions...