Jennifer K Quint
A5044010239- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Chronic Disease Management Strategies
- Long-Term Effects of COVID-19
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Health Promotion and Cardiovascular Prevention
- Climate Change and Health Impacts
- Respiratory and Cough-Related Research
- COVID-19 and healthcare impacts
- Emergency and Acute Care Studies
- COVID-19 and Mental Health
- Heart Failure Treatment and Management
- Air Quality and Health Impacts
- Nursing Diagnosis and Documentation
- Intensive Care Unit Cognitive Disorders
- Pediatric health and respiratory diseases
- Delphi Technique in Research
- Inhalation and Respiratory Drug Delivery
- Respiratory viral infections research
- Health Systems, Economic Evaluations, Quality of Life
- Pulmonary Hypertension Research and Treatments
- Pneumonia and Respiratory Infections
- Lung Cancer Diagnosis and Treatment
Imperial College London
2016-2025
Lung Institute
2016-2024
NIHR Imperial Biomedical Research Centre
2021-2024
University of Edinburgh
2024
Health Data Research UK
2019-2024
Imperial College Healthcare NHS Trust
2020-2024
British Lung Foundation
2021-2023
University College London
2008-2023
University of Manchester
2023
Manchester Academic Health Science Centre
2023
2022 ESC/ERS pulmonary hypertension guidelines incorporate changes and adaptations focusing on clinical management https://bit.ly/3QtUvb4
There is a paucity of data on incidence, prevalence and mortality associated with non-cystic fibrosis bronchiectasis.Using the Clinical Practice Research Datalink for participants registered between January 1, 2004 December 31, 2013, we determined bronchiectasis in UK investigated changes over time.The incidence point increased yearly during study period. Across all age groups, women from 21.2 per 100 000 person-years to 35.2 2013 men 18.2 26.9 2013. The 350.5 566.1 301.2 485.5 Comparing...
Exacerbations of chronic obstructive pulmonary disease (COPD) are an increasing cause hospitalisations and associated with accelerated progression airflow obstruction. Approximately half COPD exacerbations bacteria many patients have lower airways colonisation. This suggests that bacterial infection in could be due to reduced pathogen removal. study investigated whether clearance by macrophages is defective COPD. Phagocytosis fluorescently labelled polystyrene beads Haemophillus influenzae...
No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge COVID-19, identify factors associated patient-perceived recovery, and potential therapeutic targets by describing the underlying inflammatory profiles of previously described clusters at 5 months discharge.
BackgroundThere are concerns that the response to COVID-19 pandemic in UK might have worsened physical and mental health, reduced use of health services. However, scale problem is unquantified, impeding development effective mitigations. We aimed ascertain what has happened general practice contacts for acute outcomes during pandemic.MethodsUsing de-identified electronic records from Clinical Research Practice Datalink (CPRD) Aurum (covering 13% population), between 2017 2020, we calculated...
The optimal method of identifying people with chronic obstructive pulmonary disease (COPD) from electronic primary care records is not known. We assessed the accuracy different approaches using Clinical Practice Research Datalink, a UK health record database.951 participants registered CPRD practice in between 1 January 2004 and 31 December 2012. Individuals were selected for ≥1 8 algorithms to identify COPD. General practitioners sent brief questionnaire additional evidence support COPD...
The impact of coronavirus disease (COVID-19) on patients with interstitial lung (ILD) has not been established.
Background The association between current tobacco smoking, the risk of developing symptomatic COVID-19 and severity illness is an important information gap. Methods UK users Zoe Symptom Study app provided baseline data including demographics, anthropometrics, smoking status medical conditions, were asked to log their condition daily. Participants who reported that they did not feel physically normal then by complete a series questions, 14 potential symptoms about hospital attendance. main...
Immunocompromised individuals are not optimally protected by COVID-19 vaccines and potentially require additional preventive interventions to mitigate the risk of severe COVID-19. We aimed characterise describe across immunocompromised groups as pandemic began transition an endemic phase.
Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-19) lung fibrosis suggest severe acute respiratory syndrome 2 (SARS-CoV-2) infection may lead to progressive damage. Objectives: The UK Interstitial Lung Disease Consortium (UKILD) post–COVID-19 study interim analysis was planned estimate the prevalence of residual abnormalities in people hospitalized with COVID-19 on basis risk strata. Methods: PHOSP–COVID-19 (Post-Hospitalization COVID-19) used capture...
Studies have shown that chronic obstructive pulmonary disease (COPD) exacerbation events are related to future events; however, previous literature typically reports frequent vs infrequent exacerbations per patient-year and no studies investigated increasing number of severe in relation COPD outcomes.To investigate the association between baseline frequency severity subsequent mortality risk a cohort.Clinical Practice Research Datalink (CPRD) Aurum Hospital Episode Statistics data were used...
Post-COVID cognitive deficits, including 'brain fog', are clinically complex, with both objective and subjective components. They common debilitating, can affect the ability to work, yet their biological underpinnings remain unknown. In this prospective cohort study of 1,837 adults hospitalized COVID-19, we identified two distinct biomarker profiles measured during acute admission, which predict outcomes 6 12 months after COVID-19. A first profile links elevated fibrinogen relative...
One in ten severe acute respiratory syndrome coronavirus 2 infections result prolonged symptoms termed long disease (COVID), yet phenotypes and mechanisms are poorly understood
Long COVID is a debilitating multisystem condition. The objective of this study was to estimate the prevalence long in adult population Scotland, and identify risk factors associated with its development.
Community-acquired lower respiratory tract infections (LRTI) and pneumonia (CAP) are common causes of morbidity mortality among those aged ≥65 years; a growing population in many countries. Detailed incidence estimates for these older adults the United Kingdom (UK) lacking. We used electronic general practice records from Clinical Practice Research Data link, linked to Hospital Episode Statistics inpatient data, estimate community-acquired LRTI CAP UK between April 1997-March 2011, by age,...
Chronic obstructive pulmonary disease is associated with exacerbations. Some patients are prone to frequent exacerbations and these individuals have a worse quality of life, greater limitation their daily activity faster progression than less A prospective study in well-characterised cohort was performed it assessed whether depression, as determined by the Centre for Epidemiologic Studies Depression Scale, related exacerbation frequency, systemic inflammation various social factors. The...