A5048287553- Toxin Mechanisms and Immunotoxins
- Transgenic Plants and Applications
- Nutrition and Health in Aging
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Photosynthetic Processes and Mechanisms
- Frailty in Older Adults
- Stress Responses and Cortisol
- Cell death mechanisms and regulation
- Sepsis Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
- Plant Virus Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Glycosylation and Glycoproteins Research
- Plant tissue culture and regeneration
- COVID-19 Clinical Research Studies
- Calcium signaling and nucleotide metabolism
- Lipid metabolism and biosynthesis
- Tryptophan and brain disorders
- Immune cells in cancer
- Exercise and Physiological Responses
University of Birmingham
2016-2025
NIHR Surgical Reconstruction and Microbiology Research Centre
2016-2025
Versus Arthritis
2020-2025
NIHR Birmingham Biomedical Research Centre
2006-2025
University Hospitals Birmingham NHS Foundation Trust
2016-2024
Medical Research Council
2004-2024
Queen Elizabeth Hospital Birmingham
2014-2024
National Institute for Health Research
2019-2024
Université Paris-Saclay
2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with a range of persistent symptoms impacting everyday functioning, known as post-COVID-19 condition or long COVID. We undertook retrospective matched cohort study using UK-based primary care database, Clinical Practice Research Datalink Aurum, to determine that are confirmed SARS-CoV-2 beyond 12 weeks in non-hospitalized adults and the risk factors developing symptoms. selected 486,149 1,944,580...
The impact of COVID-19 on physical and mental health employment after hospitalisation with acute disease is not well understood. aim this study was to determine the effects COVID-19-related employment, identify factors associated recovery, describe recovery phenotypes. Post-hospitalisation (PHOSP-COVID) a multicentre, long-term follow-up adults (aged ≥18 years) discharged from hospital in UK clinical diagnosis COVID-19, involving an assessment between 2 7 months discharge, including detailed...
Abstract Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook present study to identify immune and stromal that are soon after clinical onset arthritis (RA) by assessing a panel T cell, macrophage, cell related cytokines chemokines synovial fluid patients with early synovitis. Synovial was aspirated from inflamed joints inflammatory duration 3 months or less, whose outcomes were subsequently determined follow up. For comparison, acute crystal...
Ricin is an abundant protein component of Ricinus communis seeds (castor beans) that exquisitely toxic to mammalian cells. It consists enzymic polypeptide catalyzes the N-glycosidic cleavage a specific adenine residue from 28S ribosomal RNA, joined by single disulfide bond galactose (cell)-binding lectin. The enzymatic activity renders ribosomes containing depurinated RNA incapable synthesis. bipartite molecular structure ricin allows it bind cell surface, enter via endocytic uptake, and...
Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect aging on neutrophil bactericidal responses, comparing function in healthy, young (23-35 years) and elderly (>65 volunteers. Superoxide generation response fMLP was slightly increased neutrophils from donors, serum able opsonize E. coli efficiently. In contrast, phagocytic index significantly lower elderly, compared with donors (P<0.005). CD11a CD11b expression not...
No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge COVID-19, identify factors associated patient-perceived recovery, and potential therapeutic targets by describing the underlying inflammatory profiles of previously described clusters at 5 months discharge.
The properties of a discrete membranous fraction isolated on sucrose gradients from castor bean endosperm have been examined. This was previously shown to be the exclusive site phosphorylcholine-glyceride transferase. distribution NADPH-cytochrome c reductase and antimycin insensitive NADH-cytochrome across gradient followed closely that also had NADH diaphorase activity contained cytochromes b5 P 450. On containing 1 mM EDTA this mean isopycnic density 1.12 g/cm3 sedimented separately...
Older adults are less able to produce a protective antibody response vaccinations. One factor that contributes this is immune ageing. Here we examined whether diurnal variations in responses might extend the vaccination. We utilised cluster-randomised trial design. 24 General Practices (GPs) across West Midlands, UK who were assigned morning (9–11 am; 15 surgeries) or afternoon (3–5 pm; 9 vaccination times for annual influenza programme. 276 (aged 65+ years and without current infection...
Neutrophil extracellular traps (NETs) are a recently discovered addition to the defensive armamentarium of neutrophils, assisting in immune response against rapidly dividing bacteria. Although older adults more susceptible such infections, no study has examined whether aging humans influences NET formation. We report that TNF-α-primed neutrophils generate significantly NETs than unprimed and lipopolysaccharide (LPS)- interleukin-8 (IL-8)-induced formation exhibits significant age-related...
Forming the first line of defence against virally infected and malignant cells, natural killer (NK) cells are critical effector innate immune system. With age, significant impairments have been reported in two main mechanisms by which NK confer host protection: direct cytotoxicity secretion immunoregulatory cytokines chemokines. In elderly subjects, decreased cell activity has shown to be associated with an increased incidence severity viral infection, highlighting clinical implications that...
There is no criterion reference for assessing healthy ageing and this creates difficulties when conducting comparing research on across studies. A cardinal feature of loss function which translates into wide-ranging consequences the individual family, carers society. We undertook comprehensive reviews literature searching biomarkers five ageing-related domains including physical capability cognitive, physiological musculoskeletal, endocrine immune functions. Where available, we used existing...
Summary It is widely accepted that aging accompanied by remodelling of the immune system including thymic atrophy and increased frequency senescent T cells, leading to compromise. However, physical activity, which influences immunity but declines dramatically with age, not considered in this literature. We assessed profiles 125 adults (55–79 years) who had maintained a high level activity (cycling) for much their adult lives, 75 age‐matched older 55 young involved regular exercise. The naïve...
The aim of this study was to measure neutrophil function longitudinally following burn injury and examine the relationship between dysfunction sepsis.Sepsis prevalence its associated mortality is high injury, sepsis diagnosis complicated by ongoing inflammatory response. Previous studies have suggested that may underlie infection rates postburn; however, has not been thoroughly characterized over time in burns patients.Neutrophil phagocytosis, oxidative burst capacity, extracellular trap...
Importance Patients with septic shock undergo adrenergic stress, which affects cardiac, immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse effects of catecholamine exposure has been associated reduced mortality. Objectives To assess efficacy safety landiolol in patients tachycardia established requiring prolonged (&amp;gt;24 hours) vasopressor support. Design, Setting, Participants An open-label, multicenter, randomized trial involving 126 adults (≥18...