A5049107081- Electromagnetic Fields and Biological Effects
- Carcinogens and Genotoxicity Assessment
- Noise Effects and Management
- Hearing Loss and Rehabilitation
- Ultrasound and Hyperthermia Applications
- Cancer therapeutics and mechanisms
- Pharmacogenetics and Drug Metabolism
- HER2/EGFR in Cancer Research
- Vehicle Noise and Vibration Control
- Skin Protection and Aging
- Effects of Radiation Exposure
- Hearing, Cochlea, Tinnitus, Genetics
- Wireless Body Area Networks
- Effects and risks of endocrine disrupting chemicals
- Human Health and Disease
- Chronic Myeloid Leukemia Treatments
- DNA Repair Mechanisms
- Radiation Effects and Dosimetry
- Microbial Inactivation Methods
- Chronic Lymphocytic Leukemia Research
- Radioactive contamination and transfer
- Molecular Biology Techniques and Applications
- Radiation Therapy and Dosimetry
- Animal testing and alternatives
- Drug Transport and Resistance Mechanisms
Health Canada
2015-2025
Carleton University
2022
Creative Commons
2016
University of British Columbia
2016
University of Ottawa
2016
Université de Montréal
2016
Public Health Agency of Canada
2016
Statistics Canada
2016
Children's Hospital of Eastern Ontario
2016
Rajamangala University of Technology Isan
2012
Importance Patients with septic shock undergo adrenergic stress, which affects cardiac, immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse effects of catecholamine exposure has been associated reduced mortality. Objectives To assess efficacy safety landiolol in patients tachycardia established requiring prolonged (>24 hours) vasopressor support. Design, Setting, Participants An open-label, multicenter, randomized trial involving 126 adults (≥18...
The absorption and fluorescence spectra, quantum yields, lifetimes time-resolved spectra are reported for nine different fluorescent DNA-dyes. work was initiated in search of a quantitative method to detect the ratio single-to-double stranded DNA (ssDNA/dsDNA) solution based on photophysics dye–DNA complexes; result is comprehensive study providing vast amount information users stains. dyes examined were bisbenzimide or indole-derived stains (Hoechst 33342, Hoechst 33258...
The aim of this study was to estimate the prevalence hearing loss (HL), self-reported occupational noise exposure, and protection usage among Canadians.
There are no nationally representative hearing loss (HL) prevalence data available for Canadian youth using direct measurements. The present study objectives were to estimate national of HL audiometric pure-tone thresholds (0.5 8 kHz) and or distortion product otoacoustic emissions (DPOAEs) children adolescents, aged 3 19 years.This cross-sectional population-based presents findings from the 2012/2013 Health Measures Survey, entailing an in-person household interview measurements conducted...
The World Health Organization Environmental Noise Guidelines provide source-based nighttime sound level (Lnight) recommendations. For non-aircraft sources, the recommended Lnight is where absolute prevalence of high sleep disturbance (HSD) equals 3%. Guideline Development Group did not an for wind turbines due to inadequate data. In current study, calculated outdoor turbine levels ranged from <20.5 41.5 dB(A). Between May and September 2013, questionnaires were completed by 606 males...
Human blood cultures were exposed to a 1.9 GHz continuous-wave (CW) radiofrequency (RF) field for 2 h using series of six circularly polarized, cylindrical waveguides. Mean specific absorption rates (SARs) 0.0, 0.1, 0.26, 0.92, 2.4 and 10 W/kg achieved, the temperature within during 2-h exposure was maintained at 37.0 +/- 0.5 degrees C. Concurrent negative (incubator) positive (1.5 Gy (137)Cs gamma radiation) control run each experiment. DNA damage quantified immediately after RF-field...
We have evaluated a flow cytometric method that allows assessment of micronucleated reticulocytes (MN-RETs) in microliter quantities peripheral blood and compared results using this assay with those established microscopic methods scoring bone marrow from rats treated well-characterized genotoxic agents. Young (RETs) are labeled FITC–anti-CD71 (transferrin receptor) micronuclei propidium iodide (with RNase treatment). Red cells parasitized Plasmodia serve as calibration standard for DNA...
The dicentric chromosome assay (DCA) is the gold-standard for accurately estimating unknown radiological doses to individuals following or nuclear accidents. However in a mass-casualty scenario, this not well suited providing timely dose estimates due its time- and expertise-intensive nature. In Canada, two approaches are being developed an attempt increase triage-quality biological dosimetry throughput. These 1) increasing number of trained personnel capable conducting DCA, 2) evaluating...
Traditionally, the dicentric chromosome assay (DCA) has been used to derive biological dose estimates for unknown radiological exposures. While sensitive, this requires highly trained evaluators and is extremely time consuming. The cytokinesis-block micronucleus (CBMN) suggested as an alternative DCA, it much faster evaluate samples less technical expertise. In order validate triage biodosimetry, dose-response curves were generated six donors at eight doses of gamma-radiation (0-4.0 Gy)....
The absorption and fluorescence spectra, quantum yields, lifetimes time-resolved spectra are reported for nine different fluorescent DNA-dyes. work was initiated in search of a quantitative method to detect the ratio single-to-double stranded DNA (ssDNA/dsDNA) solution based on photophysics dye–DNA complexes; result is comprehensive study providing vast amount information users stains. dyes examined were bisbenzimide or indole-derived stains (Hoechst 33342, Hoechst 33258...
Abstract Purpose The landiolol and organ failure in patients with septic shock (STRESS-L study) included a pre-planned sub-study to assess the effect of treatment on inflammatory metabolomic markers. Methods Samples collected from 91 randomised STRESS-L were profiled for immune A panel pro- anti-inflammatory cytokines measured through commercially acquired multiplex Luminex assays statistically analysed by individual cluster-level analysis (patient). Metabolite fingerprinting was carried out...
McNamee, J. P., Bellier, P. V., Gajda, G. B., Lavallée, B. F., Marro, L., Lemay, E. and Thansandote, A. No Evidence for Genotoxic Effects from 24 h Exposure of Human Leukocytes to 1.9 GHz Radiofrequency Fields. Radiat. Res. 159, 693–697 (2003).The current study extends our previous investigations 2-h radiofrequency (RF)-field exposures on genotoxicity in human blood cell cultures by examining the effect 24-h continuous-wave (CW) pulsed-wave (PW) RF-field both primary DNA damage micronucleus...