A5111817326- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- DNA Repair Mechanisms
- Animal testing and alternatives
- Computational Drug Discovery Methods
- DNA and Nucleic Acid Chemistry
- Molecular Biology Techniques and Applications
- Toxic Organic Pollutants Impact
- Genetically Modified Organisms Research
- Immunotoxicology and immune responses
- Mitochondrial Function and Pathology
- Gene expression and cancer classification
- Pesticide Exposure and Toxicity
- Environmental Toxicology and Ecotoxicology
- Metabolomics and Mass Spectrometry Studies
- Chromosomal and Genetic Variations
- Pluripotent Stem Cells Research
- Contact Dermatitis and Allergies
- Estrogen and related hormone effects
- RNA Interference and Gene Delivery
- bioluminescence and chemiluminescence research
- Chemical Safety and Risk Management
- Radiation Effects and Dosimetry
- Hematopoietic Stem Cell Transplantation
- Pharmacogenetics and Drug Metabolism
National Institute of Environmental Health Sciences
2012-2024
BASF (United States)
2020
Robert Bosch (Germany)
2020
Research Triangle Park Foundation
1992-2019
Sanofi (Germany)
2019
Creative Scientist (United States)
2018
National Institutes of Health
1979-2017
United States Department of Health and Human Services
2016
Triangle
2000-2015
Johns Hopkins University
1973-2015
Atthe International Workshop on Genotoxicity Test Procedures (IWGTP) held in Washington, DC, March 25-26, 1999, an expert panel met to develop guidelines for the use of single-cell gel (SCG)/Comet assay genetic toxicology. The reached a consensus that optimal version Comet identifying agents with genotoxic activity was alkaline (pH > 13) developed by Singh et al. [1988]. pH 13 is capable detecting DNA single-strand breaks (SSB), alkali-labile sites (ALS), DNA-DNA/DNA-protein cross-linking,...
Abstract Forty‐nine chemicals were tested in a mouse bone marrow micronucleus test that employed three daily exposures by intraperitoneal injection. Bone samples obtained 24 hr following the final exposure. Twenty‐five rodent carcinogens and noncarcinogens selected randomly from 44 29 used Tennant et al. (Science 236:933–941, 1987) to evaluate performance of four vitro genetic toxicity tests. As study tests, tests conducted with coded results (positive or negative) determined prior decoding....
The propensity of compounds to produce adverse health effects in humans is generally evaluated using animal-based test methods. Such methods can be relatively expensive, low-throughput, and associated with pain suffered by the treated animals. In addition, differences species biology may confound extrapolation human effects.The National Toxicology Program Institutes Health Chemical Genomics Center are collaborating identify a battery cell-based screens prioritize for further toxicologic...
Abstract As part of a comprehensive investigation the potential genotoxicity radiofrequency (RF) signals emitted by cellular telephones, in vitro studies evaluated induction DNA and chromosomal damage human blood leukocytes lymphocytes, respectively. The were voice modulated 837 MHz produced an analog signal generator or time division multiple access (TDMA) telephone, generated code (CDMA) telephone (not modulated), 1909.8 global system mobile communication (GSM)‐type personal systems (PCS)...
The large and increasing number of chemicals released into the environment demands more efficient cost-effective approaches for assessing environmental chemical toxicity. U.S. Tox21 program has responded to this challenge by proposing alternative strategies toxicity testing, among which quantitative high-throughput screening (qHTS) paradigm been adopted as primary tool generating data from libraries using a wide spectrum assays.The goal study was develop methods evaluate generated these...