A5071104612- Biblical Studies and Interpretation
- Cell death mechanisms and regulation
- Immune Response and Inflammation
- Religion, Spirituality, and Psychology
- Stress Responses and Cortisol
- Bioactive Natural Diterpenoids Research
- Sepsis Diagnosis and Treatment
- Christian Theology and Mission
- Religious Education and Schools
- Cognitive Science and Mapping
- Medieval Philosophy and Theology
- Theological Perspectives and Practices
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Cell Function and Interaction
- Molecular Spectroscopy and Structure
- Religious Studies and Spiritual Practices
- Karl Barth and Christian Theology
- Pentecostalism and Christianity Studies
- Intensive Care Unit Cognitive Disorders
- Trauma and Emergency Care Studies
- Augustinian Studies and Theology
- Acute Myeloid Leukemia Research
- NF-κB Signaling Pathways
- Psychology of Moral and Emotional Judgment
- Religious Tourism and Spaces
University of Oxford
2014-2025
University of Birmingham
2010-2019
Medical Research Council
2005-2019
University Hospitals Birmingham NHS Foundation Trust
2018-2019
Queen Elizabeth Hospital Birmingham
2014-2018
National Health Service
2018
NIHR Surgical Reconstruction and Microbiology Research Centre
2014-2016
Queen Elizabeth Hospital
2016
Karus Therapeutics (United Kingdom)
2016
Oxford Research (Norway)
2013-2014
The aim of this study was to measure neutrophil function longitudinally following burn injury and examine the relationship between dysfunction sepsis.Sepsis prevalence its associated mortality is high injury, sepsis diagnosis complicated by ongoing inflammatory response. Previous studies have suggested that may underlie infection rates postburn; however, has not been thoroughly characterized over time in burns patients.Neutrophil phagocytosis, oxidative burst capacity, extracellular trap...
Physiological aging is accompanied by a marked reduction in natural killer (NK) cell cytotoxicity (NKCC) at the single level, but underlying mechanisms are unknown. To address this issue, we isolated NK cells from healthy young (≤ 35 years) and old 60 subjects examined effect of age on events fundamental to process NKCC. Simultaneous assessment NKCC cell-target conjugate formation revealed age-associated decline killing comparable formation, indicating post-target binding defect was...
Abstract Harnessing neutrophils for the eradication of cancer cells remains an attractive but still controversial notion. In this study, we provide evidence that are required to prevent relapse skin tumors following topical treatment with a new anticancer agent, ingenol-3-angelate (PEP005). Topical PEP005 induces primary necrosis tumor cells, potently activates protein kinase C, and was associated acute T cell-independent inflammatory response characterized by pronounced neutrophil...
X-Ray photoelectron spectra of a variety uranium oxides have been studied and compared with the spectrum obtained from pure metal. The oxide phases were UO2·0, UO2·1, UO2·2, U4O9, U3O7, U3O8, γ-UO3 where formal oxidation number alters IV to VI. Significant chemical shifts observed for U 4f O 1s peaks are explained by consideration structure changes in oxygen states. surface dioxide powder air has comparing those UO2 pellets higher oxides.
Almost all studies that have investigated the immune response to trauma analysed blood samples acquired post-hospital admission. Thus, we know little of status patients in immediate postinjury phase and how this might influence patient outcomes. The objective study was therefore comprehensively assess ultra-early, within 1-hour, perform an exploratory analysis its relationship with development multiple organ dysfunction syndrome (MODS).The inflammatory 89 adult (mean age 41 years, range...
Objective Mortality in patients with primary adrenal insufficiency (PAI) is significantly increased, respiratory infections as a major cause of death. Moreover, PAI report an increased rate non-fatal infections. Neutrophils and natural killer (NK) cells are innate immune that provide frontline protection against invading pathogens. Thus, we compared the function phenotype NK neutrophils isolated from healthy controls to ascertain whether altered responses could be contributory factor for...
The purpose of this study was to determine whether circulating pro-inflammatory cytokines, elevated with increased fat mass and ageing, were associated muscle properties in young older people variable adiposity.Seventy-five (18-49 yrs) 67 (50-80 healthy, untrained men women (BMI: 17-49 kg/m2) performed isometric isokinetic plantar flexor maximum voluntary contractions (MVCs). Volume (Vm), fascicle pennation angle (FPA), physiological cross-sectional area (PCSA) the gastrocnemius medialis...
This collection of original contributions provides a showcase the many exciting and innovative developments that are currently taking place in imagery research. book should be interest to cognitive psychology.
The diterpene ester ingenol-3-angelate (referred to as PEP005) is derived from the plant Euphorbia peplus. Crude euphorbia extract causes local toxicity and transient inflammation when applied topically has been used in treatment of warts, skin keratoses cancer. PEP005 a broad range activator classical (α, β, γ) novel (δ, ε, η, θ) protein kinase C isoenzymes. Direct pro-apoptotic effects this drug have demonstrated several malignant cells, including melanoma cell lines primary human acute...
Abstract The effects of dilution in various organic solvents on the proton and 13C chemical shifts (at natural abundance) methyl group have been measured for polar solutes iodide acetonitrile. results are discussed terms distortion solute molecule by its electrostatic interaction with surrounding medium (reaction field effect). Using an expression reaction derived from spherical cavity model Onsager, it is found that cannot be accounted inserting static dielectric constants ε solvents. are,...
The Aristotelian virtue phronesis economically yet comprehensively integrates moral perception with action. Though aspects of characterize many complex skills, we claim that, in the right circumstances, thinking and acting phronetically can facilitate fast slow choices be involved governance both intuitively guided intentional Phronesis , working values affordances, reveals fittingness potential actions to actor, indicating which action is best. By relating (though not directly equating)...
Two experiments of the successive vaporization type, five mass spectrometric experiments, and two isomolecular exchange reaction were undertaken to resolve discrepancies in thermodynamics titanium—oxygen system. The first types confirmed that Ti3O5(s) is congruently vaporizing phase. second type experiment showed principal accounting for congruent Ti3O5(S)=TiO(g)+2TiO2(g). In third experiment, measurements on TiO(g)+Sc(g)=Ti(g)+ScO(g) dissociation energy TiO(g) smaller than ScO(g) basis...
Neutrophils are the most abundant leukocyte and play a central role in immune defense against rapidly dividing bacteria. However, they also shortest lived cell blood with lifespan circulation of 5.4 days. The mechanisms underlying their short spontaneous entry into apoptosis poorly understood. Recently, broad range cyclin-dependent kinase (CDK) inhibitor R-roscovitine was shown to increase neutrophil apoptosis, implicating CDKs regulation lifespan. To determine which were involved regulating...
Abstract The total synthesis of bistramide A and its 36( Z ),39( S ) R isomers shows that these compounds have different effects on cell division apoptosis. relies a novel enol ether‐forming reaction for the spiroketal fragment, kinetic oxa‐Michael cyclization tetrahydropyran an asymmetric crotonylation amino acid fragment. Preliminary biological studies show distinct pattern influence each three division, differentiation, apoptosis in HL‐60 cells, thus suggesting are independent activities...
Hip fracture is a common trauma in older adults with high incidence of depression, which relates to poorer prognosis including increased risk infection. Ageing accompanied by reduced immunity, termed immunesenescence, resulting susceptibility We examined whether physical (hip fracture) and psychological distress (depressive symptoms) had additive effects upon the aged immune system that might contribute poor outcomes after injury. Neutrophil function was assessed 101 hip patients (81 female)...
Extracellular vesicles (EV) released into the circulation after traumatic injury may influence complications. We thus evaluated numbers of EV in plasma over 28 days trauma and their pro-coagulant inflammatory effects.37 patients suffering with an severity score >15 were studied along 24 healthy controls. Plasma samples isolated by double centrifugation (2000g 20min; 13000g 2min) from blood collected within hour up to injury. counted sized using nanoparticle tracking analysis (NTA); counts...