David N Naumann
A5038020723- Trauma and Emergency Care Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Sepsis Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Cardiac Arrest and Resuscitation
- Gallbladder and Bile Duct Disorders
- Hip and Femur Fractures
- Abdominal Trauma and Injuries
- Disaster Response and Management
- Appendicitis Diagnosis and Management
- Surgical Simulation and Training
- Health and Conflict Studies
- Trauma Management and Diagnosis
- Emergency and Acute Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Hemodynamic Monitoring and Therapy
- Colorectal Cancer Screening and Detection
- Healthcare professionals’ stress and burnout
- Colorectal Cancer Surgical Treatments
- Hernia repair and management
- Diversity and Career in Medicine
University of Birmingham
2016-2025
Royal Navy
2013-2025
University Hospitals Birmingham NHS Foundation Trust
2015-2025
Queen Elizabeth Hospital Birmingham
2016-2025
Royal Victoria Hospital
2014-2025
University of Ulster
2014-2025
Heartlands Hospital
2014-2024
Nottingham University Hospitals NHS Trust
2022-2023
Queen's Medical Centre
2022-2023
University of Nottingham
2023
Background Time to treatment matters in traumatic haemorrhage but the optimal prehospital use of blood major trauma remains uncertain.We investigated whether packed red cells (PRBC) and lyophilised plasma (LyoPlas) was superior 0•9% sodium chloride for improving tissue perfusion reducing mortality trauma-related haemorrhagic shock. MethodsResuscitation with pre-hospital products (RePHILL) is a multicentre, allocation concealed, open-label, parallel group, randomised, controlled, phase 3...
Almost all studies that have investigated the immune response to trauma analysed blood samples acquired post-hospital admission. Thus, we know little of status patients in immediate postinjury phase and how this might influence patient outcomes. The objective study was therefore comprehensively assess ultra-early, within 1-hour, perform an exploratory analysis its relationship with development multiple organ dysfunction syndrome (MODS).The inflammatory 89 adult (mean age 41 years, range...
ABSTRACT Background: Trauma patients are vulnerable to coagulopathy and inflammatory dysfunction associated with endotheliopathy of trauma (EoT). In vitro evidence has suggested that tranexamic acid (TXA) may ameliorate endotheliopathy. We aimed investigate how soon after injury EoT occurs, its association multiple organ syndrome (MODS), whether TXA ameliorates it. Methods: A prospective observational study included 91 enrolled within 60 min 19 healthy controls. Blood was sampled on...
Abstract Background The aim was to describe the management of benign gallbladder disease and identify characteristics associated with all-cause 30-day readmissions complications in a prospective population-based cohort. Methods Data were collected on consecutive patients undergoing cholecystectomy acute UK Irish hospitals between 1 March May 2014. Potential explanatory variables influencing analysed by means multilevel, multivariable logistic regression modelling using two-level hierarchical...
Background The coronavirus disease 2019 (COVID-19) pandemic is likely to lead a significant increase in mental health disorders among healthcare workers (HCW). Aims We evaluated the rates of anxiety, depressive and post-traumatic stress disorder (PTSD) symptoms population HCW UK. Method An electronic survey was conducted between 5 June 2020 31 July all hospital West Midlands, UK using clinically validated questionnaires: 4-item Patient Health Questionnaire(PHQ-4) Impact Event Scale-Revised...
BACKGROUND Endothelial cell damage and glycocalyx shedding after trauma can increase the risk of inflammation, coagulopathy, vascular permeability, death. Bedside sublingual video-microscopy may detect worse flow perfusion associated with this endotheliopathy. We compared markers endotheliopathy physical dynamics traumatic hemorrhagic shock. METHODS Sublingual incident dark field was performed at three time points injury (<10 hours, 10–30 30–50 hours). Values for microcirculatory index...
Temporary defunctioning ileostomy can reduce the consequences of anastomotic leak following low anterior resection. However, some patients never have their reversed and in other cases time to reversal be delayed. The aim this study was identify closure rate resection, ileostomy, reasons for delay whether associated with an increased complication rate.Data were collected retrospectively on consecutive undergoing resection rectal cancer, between January 2009 August 2013. Data rates, reversal,...
Abstract Background There are data on the safety of cancer surgery and efficacy preventive strategies prevention postoperative symptomatic COVID-19 in these patients. But there is little such for any elective surgery. The main objectives this study were to examine bariatric (BS) during coronavirus disease 2019 (COVID-19) pandemic determine perioperative protective rates. Methods We conducted an international cohort all-cause COVID-19-specific 30-day morbidity mortality BS performed between...
Abstract Background There is a paucity of data comparing 30-day morbidity and mortality sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), one anastomosis (OAGB). This study aimed to compare the safety SG, RYGB, OAGB in propensity score-matched cohorts. Materials methods analysis utilised collected from GENEVA which was multicentre observational cohort bariatric metabolic surgery (BMS) 185 centres across 42 countries between 01/05/2022 31/10/2020 during Coronavirus Disease-2019...
Objectives: To assess the relationship between microcirculatory perfusion and multiple organ dysfunction syndrome in patients following traumatic hemorrhagic shock. Design: Multicenter prospective longitudinal observational study. Setting: Three U.K. major trauma centers. Patients: Fifty-eight intubated ventilated with Interventions: Sublingual incident dark field microscopy was performed within 12 hours of ICU admission (D0) repeated 24 48 later. Cardiac output assessed using oesophageal...
The aims of this prospective population-based cohort study were to identify the patient and hospital characteristics associated with emergency cholecystectomy, influences these in determining variations between hospitals.Data collected for consecutive patients undergoing cholecystectomy acute UK Irish hospitals 1 March May 2014. Potential explanatory variables influencing performance analysed by means multilevel, multivariable logistic regression modelling using a two-level hierarchical...
Abstract Background The optimal timing of cholecystectomy for patients admitted with acute gallbladder pathology is unclear. Some studies have shown that emergency during the index admission can reduce length hospital stay similar rates conversion to open surgery, complications and mortality compared a ‘delayed’ operation following discharge. Others reported results in higher morbidity, extended increased costs. This study examined cost-effectiveness versus delayed benign disease. Methods...
Background Cell free deoxyribonucleic acid (cfDNA) has been proposed as a biomarker of secondary complications following trauma. Raised thrombomodulin and syndecan-1 levels have used to indicate endotheliopathy, are associated with inflammation, coagulopathy, mortality. The current study aimed analyse the association between cfDNA biomarkers endotheliopathy in cohort trauma patients, whether raised were poorer clinical outcomes. Methods Serum compared plasma patients from two prospective...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), (COVID-19) presents a challenge to UK society and its health system unprecedented in peace time.[1 2][1] Naturally, many have reached for wartime metaphors capture the pandemic's impact demand resilience, community
Traumatic injury is associated with increased concentrations of cell-free DNA (cfDNA) in the circulation, which contribute to post-injury complications. The endonuclease deoxyribonuclease 1 (DNase-1) responsible for removing 90% circulating cfDNA. Recently, DNase activity was reported be significantly reduced following major non-traumatic brain (TBI), but processes were not investigated. Moreover, it known how quickly and whether this also occurs after TBI.At 3 time points (≤1, 4-12 48-72...
Abstract Background Textbook outcomes are composite outcome measures that reflect the ideal overall experience for patients. There many of these in elective surgery literature but no textbook have been proposed patients following emergency laparotomy. The aim was to achieve international consensus amongst experts and best Outcomes non-trauma trauma Methods A modified Delphi exercise undertaken with three planned rounds regarding based on category, number importance (Likert scale 1–5)...
To determine utilization and accuracy of focused assessment with sonography for trauma (FAST) computed tomography (CT) in a mature military system to inform service provision future conflicts.FAST CT scans undertaken by attending radiologists contribute surgical decision making battlefield casualties at the Joint Force, Role 3 Medical Treatment Facility Camp Bastion (R3), Afghanistan.Registry data abdominally injured treated R3 from July November 2012 were matched radiological records...