Matthew G. Tutton
A5046734467- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal and Anal Carcinomas
- Pelvic and Acetabular Injuries
- Colorectal Cancer Screening and Detection
- Hip and Femur Fractures
- Hernia repair and management
- Appendicitis Diagnosis and Management
- Angiogenesis and VEGF in Cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Enhanced Recovery After Surgery
- Congenital Diaphragmatic Hernia Studies
- Bone and Dental Protein Studies
- Biliary and Gastrointestinal Fistulas
- Gastric Cancer Management and Outcomes
- Neuroscience and Neuropharmacology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Clostridium difficile and Clostridium perfringens research
- Surgical site infection prevention
- Geological Modeling and Analysis
- Rabies epidemiology and control
- Minimally Invasive Surgical Techniques
- Multiple Sclerosis Research Studies
East Suffolk and North Essex NHS Foundation Trust
2020-2024
National Institute for Health Research
2024
University of Birmingham
2024
Colchester Hospital
2008-2020
Institute of Cancer Research
2001-2006
Croydon University Hospital
2001-2006
Cancer Research UK
2003-2006
Chase Farm Hospital
2006
King's College Hospital
2000
St Thomas' Hospital
1992-1996
BackgroundRadical surgery via total mesorectal excision might not be the optimal first-line treatment for early-stage rectal cancer. An organ-preserving strategy with selective could reduce adverse effects of without substantially compromising oncological outcomes. We investigated feasibility recruiting patients to a randomised trial comparing an excision.MethodsTREC was randomised, open-label study done at 21 tertiary referral centres in UK. Eligible participants were aged 18 years or older...
We aimed to assess the relationship of angiogenic cytokines VEGF-A, VEGF-C, and VEGF-D their receptors VEGFR-2 VEGFR-3 in adenomacarcinoma sequence metastatic spread colorectal cancer (CRC). mRNA expression levels were measured using semi-quantitative reverse transcription polymerase chain reaction 70 CRC (35 with paired mucosae) 20 adenomatous polyps. Immuohistochemistry ELISA assessed protein expression. was significantly lower both polyps CRCs compared normal mucosa (P=.0002 .002,...
Abstract Background The aim was to describe the management of benign gallbladder disease and identify characteristics associated with all-cause 30-day readmissions complications in a prospective population-based cohort. Methods Data were collected on consecutive patients undergoing cholecystectomy acute UK Irish hospitals between 1 March May 2014. Potential explanatory variables influencing analysed by means multilevel, multivariable logistic regression modelling using two-level hierarchical...
Abstract Aim Organ‐saving treatment for early‐stage rectal cancer can reduce patient‐reported side effects compared to standard total mesorectal excision (TME) and preserve quality of life. An optimal strategy achieving organ preservation longer‐term oncological outcomes are unknown; thus there is a need high trials. Method Can we S ave the rectum by watchful waiting or T rans A nal surgery following (chemo) R adiotherapy versus otal early RE ctal C ancer (STAR‐TREC) an international...
Abstract Matrix metalloproteinases, and notably the gelatinases MMP‐2 MMP‐9, have important roles in tumour invasion, metastasis angiogenesis. Our study investigates distribution of MMP‐9 colorectal cancer, correlation with plasma levels, changes following surgical resection whether levels reflect clinical staging disease course. expression 48 tumours 13 adenomatous polyps was analysed by RT‐PCR, immunohistochemistry, quantified ELISA lysates. Concentrations samples from these patients 36...
The aims of this prospective population-based cohort study were to identify the patient and hospital characteristics associated with emergency cholecystectomy, influences these in determining variations between hospitals.Data collected for consecutive patients undergoing cholecystectomy acute UK Irish hospitals 1 March May 2014. Potential explanatory variables influencing performance analysed by means multilevel, multivariable logistic regression modelling using a two-level hierarchical...
Abstract Background The optimal timing of cholecystectomy for patients admitted with acute gallbladder pathology is unclear. Some studies have shown that emergency during the index admission can reduce length hospital stay similar rates conversion to open surgery, complications and mortality compared a ‘delayed’ operation following discharge. Others reported results in higher morbidity, extended increased costs. This study examined cost-effectiveness versus delayed benign disease. Methods...
Abstract Background The ability to accurately predict operative duration has the potential optimise theatre efficiency and utilisation, thus reducing costs increasing staff patient satisfaction. With laparoscopic cholecystectomy being one of most commonly performed procedures worldwide, a tool could be extremely beneficial healthcare organisations. Methods Data collected from CholeS study on patients undergoing in UK Irish hospitals between 04/2014 05/2014 were used duration. A multivariable...
Four patients with intracranial penetrating injuries from screwdrivers are presented. Two cases were fatal; the others left functional deficits. In two of a injury was not suspected initially because history limited and significance small entry wounds appreciated. Unless these carefully examined is easily overlooked.
BACKGROUND Total mesorectal excision remains the gold standard for management of rectal cancer however local early is gaining popularity due to lower morbidity and higher acceptance by elderly frail patients. AIM To investigate results transanal endoscopic microsurgery (TEMS) approach carried out at three large centers in United Kingdom. METHODS TEMS database was retrospectively reviewed assess demographics, operative findings post clinical oncological outcomes. This a retrospective review...
Norovirus is the leading cause of epidemic gastroenteritis worldwide but disease usually self-limiting and generally only causes serious health problems in young, elderly immunocompromised. The authors report a case bowel perforation an Caucasian lady with confirmed infection genogroup II no other presumptive cause. To authors' knowledge this first such due to Norovirus. Viral should be considered list differentials when obvious can identified minimise morbidity mortality.
Introduction: Information regarding rectal cancer surgery outcomes and survival benefits in the elderly is sparse. Radical can be associated with substantial morbidity mortality. We investigated age-specific for patients undergoing radical to determine patientsMethods: Over a 10-year period data on all who underwent was performed. Patients were grouped according age eight other variables including stage (Duke's/TNM). Data analysed using computer program R. Kaplan–Meier curves estimated...
PURPOSE: A case of a solitary pancreatic metastasis from primary colonic carcinoma is reported. METHODS: The history and use carcinoembryonic antigen, computed tomography, positron emission tomography in this the follow-up colorectal cancer are reviewed. RESULTS: Recurrent disease was suspected by an increasing antigen level. However, conventional imaging with on more than one occasion failed to identify any recurrence. accurately localized scanning confirmed subsequent laparotomy....
Bouveret’s syndrome, first described in 1896 by Léon Bouveret, is rare, limited to approximately 200 published case reports date [Ariche et al.: Scand J Gastroenterol 2000;35:781–783]. It a subgroup of gallstone ileus which cholecystoduodenal fistula allows the passage that obstructs duodenum, causing gastric outlet obstruction. This unique as it describes syndrome patient with combined cholecystoduodenocolic fistulae. Gastric obstruction was successfully managed endoscopically lithotripsy....