A5063826815- Trauma and Emergency Care Studies
- Abdominal Trauma and Injuries
- Pelvic and Acetabular Injuries
- Emergency and Acute Care Studies
- Trauma Management and Diagnosis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Abdominal Surgery and Complications
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammatory Bowel Disease
- Colorectal Cancer Surgical Treatments
- Pregnancy-related medical research
- Airway Management and Intubation Techniques
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Injury Epidemiology and Prevention
- Appendicitis Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Renal and related cancers
- Pneumothorax, Barotrauma, Emphysema
- Blood transfusion and management
- Pharmaceutical studies and practices
- Pleural and Pulmonary Diseases
- Genetic factors in colorectal cancer
Ajou University
2012-2025
Ajou University Hospital
2021-2025
National Health Insurance Service
2021
National Health Insurance Service Ilsan Hospital
2021
Yonsei University
2021
Gachon University
2021
Seoul National University
2015-2020
Seoul National University Hospital
2020
Samsung Medical Center
2002-2017
Sungkyunkwan University
2002-2017
Laparoscopic gastrectomy is a widely accepted surgical technique. Recently, robotic has been developed, as an alternative minimally invasive This study aimed to evaluate the question of whether feasible and safe for treatment gastric cancer, due its learning curve.We retrospectively reviewed prospectively collected data 100 consecutive patients, from November 2008 March 2011, compared them 282 conventional laparoscopy patients during same period. The were divided into 20 initial cases; all...
Pluripotent stem cells (PSCs) have distinct metabolic properties that support their and energetic needs affect stemness. In particular, high glycolysis is critical for the generation maintenance of PSCs. However, it unknown how PSCs maintain acquire this signature. study, we found core pluripotency factors regulate directly by controlling expression glycolytic enzymes. Specifically, Oct4 governs Hk2 Pkm2, which are important enzymes determine rate flux. The overexpression Pkm2 sustains...
Abstract For cells to exit from pluripotency and commit a lineage, the circuitry of core transcription factor (CTF) network must be extinguished in an orderly manner through epigenetic modifications. However, how this choreographed remodeling at active embryonic stem cell (ESC) genes occurs during differentiation is poorly understood. In study, we demonstrate that C-terminal binding protein 2 (Ctbp2) regulates nucleosome deacetylation (NuRD)-mediated H3K27 facilitates recruitment polycomb...
Abstract Post-translational modifications of core histones affect various cellular processes, primarily through transcription. However, their relationship with the termination transcription has remained largely unknown. In this study, we show that DNA damage-activated AKT phosphorylates threonine 45 histone H3 (H3-T45). By genome-wide chromatin immunoprecipitation sequencing (ChIP-seq) analysis, H3-T45 phosphorylation was distributed throughout damage-responsive gene loci, particularly...
Abstract Background Textbook outcomes are composite outcome measures that reflect the ideal overall experience for patients. There many of these in elective surgery literature but no textbook have been proposed patients following emergency laparotomy. The aim was to achieve international consensus amongst experts and best Outcomes non-trauma trauma Methods A modified Delphi exercise undertaken with three planned rounds regarding based on category, number importance (Likert scale 1–5)...
Delirium in intensive care unit (ICU) patients poses a significant challenge, affecting patient outcomes and health efficiency. Developing an accurate, real-time prediction model for delirium represents advancement critical care, addressing needs timely intervention resource optimization ICUs. We aimed to create novel machine learning ICU using only continuous physiological data. developed models integrating routinely available clinical data, such as age, sex, monitoring device outputs,...
Transcription factors and chromatin remodeling proteins control the transcriptional variability for ESC lineage commitment. During differentiation, modifiers are recruited to regulatory regions by transcription factors, thereby activating lineage-specific genes or silencing of active genes. However, underlying mechanisms that link exit from pluripotency yet be identified. In this study, we show Ctbp2-interacting zinc finger proteins, Zfp217 Zfp516, function as linkers regulators during...
Background:We hypothesized that the recent change of sepsis definition by sepsis-3 would facilitate measurement timing for trauma patients presenting with initial systemic inflammatory response syndrome.Moreover, we investigated factors associated according to definition.Methods: Trauma in a single level I center were retrospectively reviewed from January 2014 December 2016.Exclusion criteria younger than 18 years, Injury Severity Score (ISS) < 15, length stay 8 days, transferred other...
It is controversial as to whether papillary thyroid microcarcinoma (PTMC) has some genomic and transcriptomic characteristics that differentiate between an early-stage lesion would eventually evolve into the larger cancer (PTC), occult indolent in itself. To investigate this, we comprehensively elucidated landscapes of PTMCs different sizes, using a large-scaled database. This study included 3435 PTCs, 1985 which were PTMCs. We performed targeted next-generation sequencing for 221 PTCs...
Abstract Recently, resuscitative endovascular balloon occlusion of the aorta (REBOA) had been introduced as an innovative procedure for severe hemorrhage in abdomen or pelvis. We aimed to investigate risk factors associated with mortality after REBOA and construct a model predicting mortality. This multicenter retrospective study collected data from 251 patients admitted at five regional trauma centers across South Korea 2015 2022. The indications included experiencing hypovolemic shock due...
A 48 year old woman was diagnosed with a huge cystic mass in her abdominal cavity.She complained of significant discomfort due to the mass.The computed tomography revealed giant multi-lobulated mass, measuring 26×12 cm size, adjacent lesser curvature stomach.In operation field, found originate from omentum, including right and left gastric vessels vagus nerves, invade stomach.For curative resection, distal subtotal gastrectomy excision followed by gastroduodenostomy were performed.This...
Apoptosis during engraftment and inflammation induce poor islet xenograft survival. We aimed to determine whether overexpression of human heme oxygenase-1 (HO-1) or soluble tumor necrosis factor-α receptor type I with IgG1 Fc (sTNF-αR-Fc) in porcine islets could improve Adult were transduced adenovirus containing HO-1, sTNF-αR-Fc, sTNF-αR-Fc/HO-1 green fluorescent protein (control). Humanized mice generated by injecting cord blood-derived CD34(+) stem cells into NOD-scid-IL-2Rγ(null) mice....
Haemostatic procedures such as preperitoneal pelvic packing (PPP), angiography (PA), and internal iliac artery ligation are used for haemorrhage control in fracture patients with haemodynamic instability. Pelvic external fixation (PEF) binder (PB) usually applied haemostatic to reduce the volume. This study aimed compare clinical outcomes between who underwent PEF PB. Among 173 admitted emergency room of three regional trauma centres January 2015 December 2018, electronic charts...
The canonical Wnt pathway is critical for embryonic stem cell (ESC) pluripotency and aberrant control of β-catenin leads to failure exit from lineage commitments. Hence, maintaining the appropriate level important decision commit lineage. However, how links core transcription factors in ESCs remains elusive. C-terminal-binding protein (CtBP) Drosophila essential Wnt-mediated target gene expression. In addition, Ctbp acts as an antagonist β-catenin/TCF activation mammals. Recently, Ctbp2, a...
Background/Aim: To develop a nomogram for predicting the pathological tumor response to preoperative chemoradiotherapy (CRT) locally advanced rectal cancer based on pre-treatment magnetic resonance imaging (MRI) and blood test characteristics. Patients Methods: This retrospective study included 514 patients who underwent MRI received CRT followed by surgical resection. Pathological was assessed as good [Dworak regression grade (TRG) 3 or 4] poor (TRG 0-2). A developed using stepwise logistic...
BACKGROUND This study examined the impact of performance improvement and patient safety (PIPS) program implemented in 2015 on outcomes for trauma patients a regional center established by government-led project national system Korea. METHODS The PIPS was based guidelines World Health Organization American College Surgeons. corrective strategies were proceeded according to loop closure principle: data-gathering monitoring, identification preventable deaths (PTDs), evaluation factors, analysis...
This study aimed to evaluate the accuracy and outcomes of focused assessment with sonography for trauma (FAST) determine factors associated true-positive FAST results.The results from 2016 2020 were retrospectively reviewed. Cases involving penetrating injury, transfer other hospitals, age ≤ 16 years, prehospital arrest, no confirmatory test excluded. Intra-abdominal fluid was confirmed using computed tomography or operative findings. The sensitivity, specificity, positive predictive value...
Ketamine and etomidate are commonly used as sedatives in rapid sequence intubation (RSI). However, there is no consensus on which agent should be favored when treating patients with trauma. This study aimed to compare the effects of ketamine first-pass success outcomes trauma after RSI-facilitated emergency intubation.We retrospectively reviewed 944 who underwent endotracheal a bay at Korean level 1 center between January 2019 December 2021. Outcomes were compared groups propensity score...