A5101689142- Epigenetics and DNA Methylation
- Parvovirus B19 Infection Studies
- Shoulder Injury and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Shoulder and Clavicle Injuries
- Cancer-related Molecular Pathways
- Hip disorders and treatments
- Cancer-related gene regulation
- RNA modifications and cancer
- Genetic factors in colorectal cancer
SK Group (South Korea)
2019-2020
Incheon St. Mary's Hospital
2012
Yonsei University
2011
Abstract Background Epigenetic alteration of gene expression is a common event in human cancer. DNA methylation well-known epigenetic process, but verifying the exact nature changes associated with cancer remains difficult. Methods We profiled methylome gastric tissue at 50-bp resolution using methylated enrichment technique (methylated CpG island recovery assay) combination genome analyzer and new normalization algorithm. Results were able to gain comprehensive view promoters various...
Non-invasive prenatal testing (NIPT) using cell-free fetal DNA from maternal plasma for aneuploidy identification is expanding worldwide. The objective of this study was to evaluate the clinical utility NIPT detection trisomies 21, 18, and 13 high-risk fetus in a large Korean population.
It is controversial as to whether papillary thyroid microcarcinoma (PTMC) has some genomic and transcriptomic characteristics that differentiate between an early-stage lesion would eventually evolve into the larger cancer (PTC), occult indolent in itself. To investigate this, we comprehensively elucidated landscapes of PTMCs different sizes, using a large-scaled database. This study included 3435 PTCs, 1985 which were PTMCs. We performed targeted next-generation sequencing for 221 PTCs...