A5038240309- Nanoplatforms for cancer theranostics
- Semiconductor materials and devices
- Immunotherapy and Immune Responses
- 3D Printing in Biomedical Research
- Glycosylation and Glycoproteins Research
- Ophthalmology and Eye Disorders
- Helicobacter pylori-related gastroenterology studies
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Gastroesophageal reflux and treatments
- Microbial Community Ecology and Physiology
- Advanced Data Storage Technologies
- Cardiac Arrest and Resuscitation
- Spacecraft Design and Technology
- Peptidase Inhibition and Analysis
- Energy and Environmental Systems
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Esophagitis
- Pneumothorax, Barotrauma, Emphysema
- Healthcare Education and Workforce Issues
- Thermal Regulation in Medicine
- NF-κB Signaling Pathways
- Central Venous Catheters and Hemodialysis
Mayo Clinic in Arizona
2024-2025
Terasaki Foundation
2022-2025
WinnMed
2024
Korea Atomic Energy Research Institute
2018-2024
Korea University
2023
Ajou University
2023
Chosun University
2023
Korea Advanced Institute of Science and Technology
2014-2022
Severance Hospital
2018-2022
Yonsei University
2018-2022
As reports of multidrug resistant pathogens have increased, patients with implanted medical catheters increasingly need alternative solutions to antibiotic treatments. most catheter-related infections are directly associated biofilm formation on the catheter surface, which, once formed, is difficult eliminate, a promising approach prevention involves inhibiting initial adhesion bacteria surface. In this study, we report an amphiphilic, antifouling polymer, poly(DMA-mPEGMA-AA) that can...
Standardized poly(ethylene glycol)-modified (PEGylated) liposomes, which have been widely used in research as well pre-clinical and clinical studies, are typically constructed using PEG with a molecular weight of 2000 Da (PEG ).Targeting ligands also generally conjugated various functionalized .However, although standardized protocols routinely , it is not because this has optimized to enhance tumor uptake nanoparticles.Herein, we investigated the effect lipid pairings-that is, lipids for...
Combination of photodynamic therapy (PDT) with photothermal (PTT) has achieved significantly improved therapeutic efficacy compared to a single phototherapy modality.However, most nanomaterials used for combined PDT/PTT are made non-biodegradable materials (e.g., gold nanorods, carbon nanotubes, and graphenes) may remain intact in the body long time, raising concerns over their potential long-term toxicity.Here we report new nanomedicine, designated SP 3 NPs, that exhibit photo-decomposable,...
Dynamic manipulation of supramolecular self-assembled structures is achieved irreversibly or under non-physiological conditions, thereby limiting their biomedical, environmental, and catalysis applicability. In this study, microgels composed azobenzene derivatives stacked via π-cation π-π interactions are developed that electrostatically stabilized with Arg-Gly-Asp (RGD)-bearing anionic polymers. Lateral swelling RGD-bearing occurs cis-azobenzene formation mediated by...
Abstract Three-dimensional (3D) in vitro tumor models that can capture the pathophysiology of human tumors are essential for cancer biology and drug development. However, simulating microenvironment is still challenging because it consists a heterogeneous mixture various cellular components biological factors. In this regard, current extracellular matrix (ECM)-mimicking hydrogels used tissue engineering lack physical interactions keep factors released by encapsulated cells within hydrogel...
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in psoriatic skin inflammation acts as a key player the pathogenesis progression this autoimmune disease. Although numerous inhibitors that intervene STAT3-associated pathways have been tested, an effective, highly specific inhibitor STAT3 has yet to be identified. Here, we evaluated vitro vivo biological activity therapeutic efficacy high-affinity peptide for (APTstat3) after topical treatment via...
Abstract We describe a small lipid nanoparticle (SLNP)‐based nanovaccine platform and new combination treatment regimen. Tumor antigen‐displaying, CpG adjuvant‐embedded SLNPs (OVA PEP ‐SLNP@CpG) were prepared from biocompatible phospholipids cationic cholesterol derivative. The resulting showed highly potent antitumor efficacy in both prophylactic therapeutic E.G7 tumor models. However, this vaccine induced T cell exhaustion by elevating PD‐L1 expression, leading to recurrence. Thus, the was...
Small-molecule organoselenium-based fluorescent probes possess great capacity in understanding biological processes through the detection of various analytes such as reactive oxygen/nitrogen species (ROS/RNS), biothiols (cysteine, homocysteine and glutathione), lipid droplets, etc. Herein, we present how substituents on BODIPY system play a significant part biologically important for vitro conditions live cell imaging studies. The fluorescence probe was quenched by 2-chloro 6-phenyl selenium...
In this paper, fundamental reliability findings in 14nm bulk FinFET technology, are systematically investigated. From device and Ring Oscillator stress to product-level HTOL results, we show that BTI on (110) Fin can be improved significantly with optimized process. addition, variability small Fins does not pose any risk we'll 1000hrs of data 128Mb SRAM. Self-heating effect (SHE) was characterized for both logic I/O devices verified through simulations thermal imaging product design...
The polymerase chain reaction (PCR) has been an essential tool for diagnosis of infectious diseases, but conventional PCR still some limitations with respect to applications point-of-care (POC) diagnostic systems that require rapid detection and miniaturization. Here we report a light-based method, termed as photo-PCR, which enables bacteria in single step. In the photo-PCR system, poly(enthylene glycol)-modified gold nanorods (PEG-GNRs), used heat generator, are added into mixture, is...
Extracellular matrix (ECM) undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been explored. Here we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo
Significance Tumor tissues have formidable physiological barriers, such as a high interstitial pressure and densely entangled ECM. Most synthetic nanomaterials used for drug delivery fail to penetrate tumor deeply localize only in perivascular areas, thereby limiting their therapeutic efficacy. This report describes bioengineered yeast-derived natural nanocarriers cancer-specific targeting delivery. Budding yeast was genetically engineered produce large numbers of nanosized...
Abstract Enterocutaneous fistulas (ECFs) profoundly impact patients’ quality of life, contributing to high morbidity rates and increased mortality due ineffective treatment options. To address this challenge, ECFGel, a multifunctional, tissue adhesive injectable hydrogel, designed occlude, sterilize, promote healing ECF tracts, is developed. ECFGel formulated using gelatin oxidized dextran (O‐Dex) as base components, which form chemical crosslinks within the hydrogel with surrounding...
3007 Background: Belvarafenib, a potent, selective RAF dimer (type II) inhibitor, exhibits clinical activity in BRAF V600E - and NRAS-mutant (NRASm) melanoma patients. The combination of belvarafenib cobimetinib more potently durably suppressed MAPK pathway output tumor growth than currently approved BRAF/MEK inhibitors RAS- or RAF-mutant xenograft models. This interim results phase 1b trial evaluated the safety, tolerability, pharmacokinetics, anti-tumor with dose-escalation NRASm patients...
Abstract Embolic materials currently in use for portal vein embolization (PVE) do not treat the tumor, which poses a risk tumor progression during interval between PVE and surgical resection. Here, is developed an ionic‐liquid‐based embolic material (LEAD) embolization, liver ablation, drug delivery. LEAD optimized characterized diffusivity, X‐ray visibility, cytotoxicity. In porcine renal model, delivered from main artery reached vasculature down to 10 microns with uniform tissue ablation...
Benign prostatic hyperplasia and prostate cancer are often associated with lower urinary tract symptoms, which can severely affect patient quality of life. To address this challenge, we developed optimized an injectable compound, ablation drug delivery agent (PADA), for percutaneous tissue concurrently delivered therapeutic agents. PADA is ionic liquid composed choline geranic acid mixed anticancer therapeutics a contrast agent. The formulation was mechanical properties compatible hand...