A5101823414- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Cerebrospinal fluid and hydrocephalus
- Micro and Nano Robotics
- Supramolecular Self-Assembly in Materials
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Ultrasound and Hyperthermia Applications
- Silicon Nanostructures and Photoluminescence
- Graphene and Nanomaterials Applications
- Advanced Photocatalysis Techniques
- Metal-Organic Frameworks: Synthesis and Applications
- 3D Printing in Biomedical Research
- Quantum Dots Synthesis And Properties
- Advanced Battery Technologies Research
- Indoor Air Quality and Microbial Exposure
- Molecular Communication and Nanonetworks
- Polyomavirus and related diseases
- Microfluidic and Bio-sensing Technologies
- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Advanced Biosensing Techniques and Applications
Korea Institute of Science and Technology
2021-2025
California Institute of Technology
2023-2025
Ulsan National Institute of Science and Technology
2022-2025
Government of the Republic of Korea
2019-2021
Pohang University of Science and Technology
2016-2020
Sookmyung Women's University
2019-2020
This review covers recent progress in atomic doping and surface functionalization of carbon nanodots to improve their functionality for a variety applications ranging from biomedicine optoelectronics energy.
Abstract The diagnosis of liver diseases is generally carried out via ultrasound imaging, computed tomography, and magnetic resonance imaging. emerging photoacoustic imaging an attractive alternative to diagnose even early stage providing high‐resolution anatomical functional information in deep tissue noninvasively. However, the has insufficient contrast due low optical absorbance near‐infrared windows. Here, a new hyaluronate–silica nanoparticle (HA–SiNP) conjugate for liver‐specific...
Autonomous nanorobots represent an advanced tool for precision therapy to improve therapeutic efficacy. However, current nanorobotic designs primarily rely on inorganic materials with compromised biocompatibility and limited biological functions. Here, we introduce enzyme-powered bacterial outer membrane vesicle (OMV) nanorobots. The immobilized urease the OMV catalyzes decomposition of bioavailable urea, generating effective propulsion This nanorobot preserves unique features OMVs,...
Dynamic manipulation of supramolecular self-assembled structures is achieved irreversibly or under non-physiological conditions, thereby limiting their biomedical, environmental, and catalysis applicability. In this study, microgels composed azobenzene derivatives stacked via π-cation π-π interactions are developed that electrostatically stabilized with Arg-Gly-Asp (RGD)-bearing anionic polymers. Lateral swelling RGD-bearing occurs cis-azobenzene formation mediated by...
Micro- and nanorobots excel in navigating the intricate often inaccessible areas of human body, offering immense potential for applications such as disease diagnosis, precision drug delivery, detoxification, minimally invasive surgery. Despite their promise, practical deployment faces hurdles, including achieving stable propulsion complex vivo biological environments, real-time imaging localization through deep tissue, precise remote control targeted therapy ensuring high therapeutic...
Afterglow is superior to other optical modalities for biomedical applications in that it can exclude the autofluorescence background. Nevertheless, afterglow has rarely been applied high-contrast "off-to-on" activatable sensing scheme because complicated systems hamper additional inclusion of sensory functions while preserving luminescence. Herein, a simple formulation multifunctional components-incorporated nanosensor (MANS) developed superoxide-responsive imaging cisplatin-induced kidney...
Challenges exist in taking advantage of dye molecules for reliable and reproducible molecular probes biomedical applications. In this study, we show how to utilize the bioimaging within protective carriers nanocrystalline metal-organic frameworks (nMOFs) particles. Specifically, Resorufin Rhodamine-6G having different sizes were encapsulated close-fitting pores nMOF-801 nUiO-67 particles, respectively. The resulting particles have high crystallinity, uniform size, morphology preserve...
In this article, we demonstrate that TiO2@carbon core/shell (TiO2@C) nanocomposite photocatalysts prepared by carbonizing a single molecular layer of aromatic compounds adsorbed on the surface TiO2 nanoparticles selectively enhance generation hydrogen peroxide (H2O2). Atomically thin carbon shells have been formed directly through pyrolytic decarboxylation compounds, benzoic acid (BA), and 1-naphthoic (NA), which yields two types TiO2@C nanocomposites, TiO2@C(BA) TiO2@C(NA). Raman...
Extracellular matrix (ECM) undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been explored. Here we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin cancer with limited treatment options, often associated polyomavirus (MCPyV) and marked by hypoxic tumor microenvironments that promote resistance to therapies. Belzutifan, an FDA-approved hypoxia-inducible factor-2α (HIF-2α) inhibitor, has shown promise in inhibiting growth; however, its clinical efficacy hindered low solubility, rapid clearance, bioavailability. In this study, we present strategy using porous silicon...
Regulating protein interactions and corona formation of nanomaterials is crucial for advancing nanomedicine, where surface engineering plays a pivotal role in precise control over biological interactions. Here, we present surface-engineered nanoparticle-based immunoassay platform using carboxyl-enriched polystyrene nanobeads (CEPS) with regioselectively controlled antibody-binding properties. Proteomic analysis theoretical simulation revealed that CEPS has an enhanced Fc-specific binding...
Three-dimensional printing offers promise for patient-specific implants and therapies but is often limited by the need invasive surgical procedures. To address this, we developed an imaging-guided deep tissue in vivo sound (DISP) platform. By incorporating cross-linking agent–loaded low-temperature–sensitive liposomes into bioinks, DISP enables precise, rapid, on-demand of diverse functional biomaterials using focused ultrasound. Gas vesicle–based ultrasound imaging provides real-time...
With increasing ozone depletion, ultraviolet (UV) exposure from sunlight has become a significant health risk. Although commercially available sun protectants provide reasonable protection, they have limitations in terms of safety and aesthetics. Here, we developed biocompatible biodegradable sunscreens by facile synthesis organosilica nanoparticles (o-SNPs) with self-encapsulated phenyl motifs using phenylsilane precursors. The physical structure o-SNPs is elaborately controlled such that...
With biocompatibility, biodegradability, and high functionality, silica nanoparticles (SNPs) have been widely investigated for various biomedical applications. However, lack of optical fluorescence has limited the application SNPs as a degradable imaging agent. Here, we hydrothermally synthesized fluorescent by artificially generating optically active defect centers using tetraethyl orthosilicate (3-aminopropyl)trimethoxysilane. The demonstrated strong blue photoluminescence originating from...
Conformational transition of PEG on a mesoporous surface for advancing cell recognition and uptake targeted siRNA delivery.
Indocyanine green (ICG) is a clinically approved dye that has shown great promise as phototheranostic material with fluorescent, photoacoustic and photothermal responses in the near-infrared region. However, it certain limitations, such poor photostability non-specific binding to serum proteins, subjected rapid clearance decreased theranostic efficacy vivo. This study reports stable biocompatible nanoparticles of ICG (ICG-Fe NPs) where electrostatically complexed an endogenously abundant...
Superoxide-sensitive fluorogenic molecular probes, benzenesulfonylated resorufin derivatives (BSRs), were newly devised for optical bioimaging of oxidative events in neurodegenerative processes.
Hybrid nanostructures are promising for ultrasound-triggered drug delivery and treatment, called sonotheranostics. Structures based on plasmonic nanoparticles photothermal-induced microbubble inflation ultrasound imaging exist. However, they have limited therapeutic applications because of short lifetimes contrast. Photochemistry-based sonotheranostics is an attractive alternative, but building near-infrared (NIR)-responsive echogenic deep tissue challenging photolysis requires high-energy...
In article number 1800941, Woosung Kwon, Sei Kwang Hahn, Chulhong Kim, and co-workers describe hyaluronate–silica-nanoparticle (HA–SiNP) conjugates for liver-specific delivery imaging. The HA–SiNP show high targeting efficiency, strong optical absorbance in near-infrared windows, excellent biocompatibility, biodegradability. efficiency is verified by vitro cellular uptake tests, vivo ex photoacoustic