A5014061372- Microfluidic and Bio-sensing Technologies
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Angiogenesis and VEGF in Cancer
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Micro and Nano Robotics
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cerebrospinal fluid and hydrocephalus
California Institute of Technology
2024
Massachusetts General Hospital
2019-2020
Harvard University
2020
Abstract Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination. Characterization of rare, heterogeneous circulating tumor cells (CTCs) can provide insight into metastasis and guide development novel therapies. Using the CTC-iChip purify CTCs from PDAC patients for RNA-seq characterization, we identify three major correlated gene sets, with stemness genes LIN28B/KLF4 , WNT5A LGALS3 enriched in each set; only LIN28B CTC expression was prognostic. CRISPR knockout...
Micro- and nanorobots excel in navigating the intricate often inaccessible areas of human body, offering immense potential for applications such as disease diagnosis, precision drug delivery, detoxification, minimally invasive surgery. Despite their promise, practical deployment faces hurdles, including achieving stable propulsion complex vivo biological environments, real-time imaging localization through deep tissue, precise remote control targeted therapy ensuring high therapeutic...
Background: HCC is a highly vascular tumor, and many effective drug regimens target the tumor blood vessels. Prior bulk subtyping data used transcriptomes, which contained mixture of parenchymal stromal contributions. Methods: We utilized computational deconvolution cell-cell interaction analyses to cell type-specific (tumor-enriched vessel-enriched) spatial transcriptomic collected from 41 resected tissue specimens. Results: report that prior Hoshida transcriptional schema driven largely by...
Cell-based therapies are a major emerging category of medicine. The ability engineered cells to traffic and function at specific anatomical locations is aspect their performance. However, there lack non-invasive, non-ionizing, cost-accessible methods track these inside the body ensure proper function. Here, we establish platform for in vivo imaging primary cell using ultrasound - ubiquitously accessible technology high-resolution non-invasive imaging. We introduce optimize lentiviral...