A5100686599- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Breast Cancer Treatment Studies
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Sulfur Compounds in Biology
- Gastric Cancer Management and Outcomes
- Brain Metastases and Treatment
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Nanoplatforms for cancer theranostics
- Lung Cancer Diagnosis and Treatment
- Renal and Vascular Pathologies
- Systemic Lupus Erythematosus Research
- Breast Lesions and Carcinomas
- Antibiotic Resistance in Bacteria
- Nanoparticles: synthesis and applications
Asan Medical Center
2012-2024
Ulsan College
2012-2024
University of Ulsan
2013-2024
Korea Advanced Institute of Science and Technology
2017-2020
The development of novel fluorescent probes for monitoring the concentration various biomolecules in living systems has great potential eventual early diagnosis and disease intervention. Selective detection competitive species biological is a challenge design probes. To improve on coumarin-based biothiol sensing technologies, we have developed herein an enhanced dual emission doubly activated system (DACP-1 closely related DACP-2) selective glutathione (GSH) through use one optical channel...
As reports of multidrug resistant pathogens have increased, patients with implanted medical catheters increasingly need alternative solutions to antibiotic treatments. most catheter-related infections are directly associated biofilm formation on the catheter surface, which, once formed, is difficult eliminate, a promising approach prevention involves inhibiting initial adhesion bacteria surface. In this study, we report an amphiphilic, antifouling polymer, poly(DMA-mPEGMA-AA) that can...
Despite the vital importance of monitoring progression nonalcoholic fatty liver disease (NAFLD) and its progressive form, steatohepatitis (NASH), an efficient imaging modality that is readily available at hospitals currently lacking. Here, a new magnetic-resonance-imaging (MRI)-based presented allows for longitudinal NAFLD NASH progression. The uses manganese-ion (Mn
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in psoriatic skin inflammation acts as a key player the pathogenesis progression this autoimmune disease. Although numerous inhibitors that intervene STAT3-associated pathways have been tested, an effective, highly specific inhibitor STAT3 has yet to be identified. Here, we evaluated vitro vivo biological activity therapeutic efficacy high-affinity peptide for (APTstat3) after topical treatment via...
Despite growing interest in targeted cancer therapy with small molecule drug conjugates (SMDCs), the short half-life of these blood associated their size has limited efficacy therapy. In this report, we propose a new approach for improving antitumor SMDCs based on nanoparticle-assisted delivery. Ideally, nanoparticle-based delivery vehicle would prolong an SMDC and then release it response to stimuli tumor microenvironment (TME). study, PEGylated bilirubin-based nanoparticles (BRNPs) were...
Rationale: Magnetic relaxation switching (MRSw) induced by target-triggered aggregation or dissociation of superparamagnetic iron oxide nanoparticles (SPIONs) have been utilized for detection diverse biomarkers.However, an MRSw-based biosensor reactive oxygen species (ROS) has never documented.Methods: To this end, we constructed a ROS based on PEGylated bilirubin (PEG-BR)-coated SPIONs (PEG-BR@SPIONs) that were prepared simple sonication via ligand exchange.In addition, near infra-red (NIR)...
To compare the diagnostic sensitivity of [18F]fluoroestradiol ([18F]FES) and [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) for breast cancer recurrence in patients with estrogen receptor (ER)-positive primary cancer.Our database consecutive enrolled a previous prospective cohort study to assess [18F]FES PET/CT was reviewed identify eligible who had ER-positive suspected first at presentation underwent [18F]FDG PET/CT. The qualitative...
The purpose of this study was to determine the 18F-FDG avidity MALT lymphoma and additional utility PET/CT in staging. Pretreatment scans 222 patients with 227 lesions were retrospectively analyzed. noted 28%. proportion lower for gastric lymphomas than non-gastric (9% vs. 60%, p<0.0001) higher mass-forming superficial (82% 2%, p<0.0001). showed presence 23 patients: four six true-positive had avid primary lesions, 15 17 false-positive 18F-FDG-non lesions. differed according location gross...
Purpose This study aimed to compare the diagnostic performances of 18 F-FDOPA PET/CT and 123 I-MIBG scintigraphy with SPECT/CT for detection pheochromocytoma paraganglioma (PPGL). Patients Methods We conducted a prospective, single-institution comparative study. suspected having PPGL or those showing recurrence and/or distant metastasis were enrolled. The primary objective was affirm noninferiority sensitivity. Both (at 4 24 hours) 5 60 minutes after radiotracer administration) performed....
We aimed to explore whether the imaging of antiporter system xC<sup>–</sup> immune cells with (4<i>S</i>)-4-(3-[<sup>18</sup>F-fluoropropyl)-L-glutamate (<sup>18</sup>F-FSPG) positron emission tomography (PET) can assess inflammatory bowel disease (IBD) activity in murine models and patients (NCT03546868). <b>Methods</b>: <sup>18</sup>F-FSPG PET was performed IBD mice dextran sulfate sodium-induced adoptive T-cell transfer-induced a cohort 20 at tertiary care center South Korea....
Peptide-based therapeutics have suffered from a short plasma half-life. On the other hand, antibodies suffer poor penetration into solid tumors owing to their large size. Herein, we present new molecular form, namely hybrid complex between hapten-labeled bispecific peptide and an anti-hapten antibody ("HyPEP-body"), that may be able overcome aforementioned limitation. The containing cotinine tag was synthesized by linking specific fibronectin extra domain B (EDB) bind inhibit vascular...
Abstract Tumor-induced osteomalacia (TIO) is an uncommon paraneoplastic syndrome presenting with sustained hypophosphatemia. Treatment of choice removal the tumor causing TIO, but identification culprit by routine imaging challenging. This study aimed to assess usefulness somatostatin receptor imaging, called 68 Ga-DOTATOC PET/CT, in management patients TIO. Twelve who were suspected having TIO underwent PET/CT. Lesion detectability and maximum standardized uptake value (SUV max ) determined...
Serum bone turnover markers offer limited insight into metabolic activity at the individual vertebra level in osteoporosis. This study introduces a novel image-derived marker for vertebrae to address this limitation, utilizing volumetric density-adjusted quantitative single-photon emission computed tomography/computed tomography (SPECT/CT) with [99mTc]Tc-DPD. retrospective included 177 lumbar from 55 postmenopausal South Korean women. The mean standardized uptake value (SUVmean, g/cm3) and...
Abstract Peptide‐based therapeutics have suffered from a short plasma half‐life. On the other hand, antibodies suffer poor penetration into solid tumors owing to their large size. Herein, we present new molecular form, namely hybrid complex between hapten‐labeled bispecific peptide and an anti‐hapten antibody (“HyPEP‐body”), that may be able overcome aforementioned limitation. The containing cotinine tag was synthesized by linking specific fibronectin extra domain B (EDB) bind inhibit...