Nawar Diar Bakerly
A5075991335- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Intensive Care Unit Cognitive Disorders
- Inhalation and Respiratory Drug Delivery
- Chronic Disease Management Strategies
- SARS-CoV-2 and COVID-19 Research
- Respiratory and Cough-Related Research
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Delphi Technique in Research
- Mobile Health and mHealth Applications
- Pneumonia and Respiratory Infections
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Vaccine Coverage and Hesitancy
- Health Literacy and Information Accessibility
- Neuroinflammation and Neurodegeneration Mechanisms
- Vagus Nerve Stimulation Research
- COVID-19 and healthcare impacts
- Frailty in Older Adults
- Pediatric health and respiratory diseases
Salford Royal Hospital
2013-2025
Manchester Academic Health Science Centre
2012-2024
University of Manchester
2012-2024
Salford Royal NHS Foundation Trust
2015-2024
Manchester Metropolitan University
2020-2024
Northern Health and Social Care Trust
2023-2024
National Institute for Health Research
2017-2023
Digital Research Alliance of Canada
2023
The Recovery Center
2022
NIHR Applied Research Collaboration Greater Manchester
2017
The impact of COVID-19 on physical and mental health employment after hospitalisation with acute disease is not well understood. aim this study was to determine the effects COVID-19-related employment, identify factors associated recovery, describe recovery phenotypes. Post-hospitalisation (PHOSP-COVID) a multicentre, long-term follow-up adults (aged ≥18 years) discharged from hospital in UK clinical diagnosis COVID-19, involving an assessment between 2 7 months discharge, including detailed...
COVID-19 pathogenesis is associated with an exaggerated immune response. However, the specific cellular mediators and inflammatory components driving diverse clinical disease outcomes remain poorly understood. We undertook longitudinal profiling on both whole blood peripheral mononuclear cells (PBMCs) of hospitalized patients during peak pandemic in UK. Here, we report key signatures present shortly after hospital admission that were severity COVID-19. Immune related to shifts neutrophil T...
Evidence for the management of chronic obstructive pulmonary disease (COPD) comes from closely monitored efficacy trials involving groups patients who were selected on basis restricted entry criteria. There is a need randomized to be conducted in conditions that are closer usual clinical practice.In controlled effectiveness trial 75 general practices, we randomly assigned 2799 with COPD once-daily inhaled combination fluticasone furoate at dose 100 μg and vilanterol 25 (the...
BackgroundEmerging studies indicate that some coronavirus disease 2019 (COVID-19) patients suffer from persistent symptoms, including breathlessness and chronic fatigue; however, the long-term immune response in these presently remains ill-defined.MethodsHere, we describe phenotypic functional characteristics of B T cells hospitalized COVID-19 during acute at 3–6 months convalescence.FindingsWe report alterations cell subsets observed were largely recovered convalescent patients. In...
An online survey was conducted to compare the safety, tolerability and reactogenicity of available COVID-19 vaccines in different recipient groups. This launched February 2021 ran for 11 days. Recipients a first vaccine dose ≥7 days prior completion were eligible. The incidence severity vaccination side effects assessed. completed by 2002 respondents whom 26.6% had infection. A infection associated with an increased risk any effect (risk ratio 1.08, 95% confidence intervals (1.05–1.11)),...
Background The impact of COVID-19 on physical and mental health, employment following hospitalisation is poorly understood. Methods PHOSP-COVID a multi-centre, UK, observational study adults discharged from hospital with clinical diagnosis involving an assessment between two- seven-months later including detailed symptom, physiological biochemical testing. Multivariable logistic regression was performed for patient-perceived recovery age, sex, ethnicity, body mass index (BMI),...
<h2>Summary</h2><h3>Introduction</h3> The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed evaluate excess burden abnormalities after hospitalisation with COVID-19, their determinants, and explore associations patient-related outcome measures. <h3>Methods</h3> In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included Tier...
Background COVID-19 is associated with a dysregulated immune response but it unclear how dysfunction contributes to the chronic morbidity persisting in many patients during convalescence (long COVID). Methods We assessed phenotypical and functional changes of monocytes hospitalisation up 9 months following COVID-19, respiratory syncytial virus or influenza A. Patients progressive fibrosing interstitial lung disease were included as positive control for severe, ongoing injury. Results...
Background Trends of occupational asthma (OA) differ between regions depending on local industries, provisions for health and safety at the workplace availability a reporting scheme to help in data collection interpretation.
We need to assess clinical treatments in real-life settings outside of randomised controlled trials (RCTs). Pragmatic RCT (pRCT) data can supplement RCTs by providing effectiveness information support healthcare decisions. Electronic health records facilitate concurrent safety monitoring and collection without direct patient contact for large study populations pRCTs. The Salford Lung Study is the world9s first phase III pRCT asthma chronic obstructive pulmonary disease (COPD), which aims...
Loss of airway microbial diversity is associated with non-typeable Haemophilus influenzae (NTHi) infection and increased risk exacerbation in chronic obstructive pulmonary disease (COPD). We assessed the safety immunogenicity an investigational vaccine containing NTHi antigens, recombinant protein D (PD) combined E Pilin A (PE-PilA), AS01 adjuvant adults moderate/severe COPD prior exacerbations. In this phase 2, observer-blind, controlled trial (NCT02075541), 145 patients aged 40–80 years...
BackgroundIt was apparent from the early phase of SARS-CoV-2 virus (COVID-19) pandemic that a multi-system syndrome can develop in weeks following COVID-19 infection, now referred to as Long COVID. Given people living with diabetes are at increased risk hospital admission/poor outcomes infection we hypothesised they may also be more susceptible developing We describe here prevalence COVID when compared matched controls Northwest UK population.MethodsThis retrospective cohort study who had...
Observational studies using case-control designs have showed an increased risk of pneumonia associated with inhaled corticosteroid (ICS)-containing medications in patients chronic obstructive pulmonary disease (COPD). New-user observational cohort may minimize biases previous designs.To estimate the association between ICS and among new users relative to long-acting bronchodilator (LABD) monotherapy.Pneumonia events COPD ≥45 years old were compared (n = 11,555; ICS, ICS/long-acting...
Novel therapies need to be evaluated in normal clinical practice allow a true representation of the treatment effectiveness real-world settings. The Salford Lung Study is pragmatic randomised controlled trial adult asthma, evaluating and safety once-daily fluticasone furoate (100 μg or 200 μg)/vilanterol 25 novel dry-powder inhaler, versus existing asthma maintenance therapy. study was initiated before this investigational licensed conducted consider adherence, co-morbidities, polypharmacy,...
New treatments need to be evaluated in real-world clinical practice account for co-morbidities, adherence and polypharmacy. Patients with chronic obstructive pulmonary disease (COPD), ≥40 years old, exacerbation the previous 3 are randomised 1:1 once-daily fluticasone furoate 100 μg/vilanterol 25 μg a novel dry-powder inhaler versus continuing their existing therapy. The primary endpoint is mean annual rate of COPD exacerbations; an electronic medical record allows real-time collection...
Abstract Background The safety of COVID-19 vaccines has been demonstrated in selected populations recent studies, but more data specific groups is needed to inform vaccine choice and health policy. Objectives An international, online survey was conducted compare the safety, tolerability reactogenicity available different recipient groups. Methods This launched February 2021, for 11 days. Recipients a first dose ≥7 days prior completion were eligible. incidence severity vaccination side...
Real-world data on the benefit/risk profile of medicines is needed, particularly in patients who are ineligible for randomised controlled trials conducted registration purposes. This paper describes methodology and source verification which enables conduct pre-licensing clinical COPD asthma community using electronic medical record (EMR), NorthWest EHealth linked database (NWEH-LDB) alert systems.Dual extracts into NWEH-LDB was performed two independent sources (Salford Integrated Record...
Guidelines for chronic obstructive pulmonary disease (COPD) management are based largely on results from double-blind randomised controlled trials (RCTs) of efficacy. These have high internal validity and test whether a drug is efficacious, but they conducted in highly selected populations that may differ significantly patients with COPD seen routine practice.We compared the baseline characteristics, healthcare use outcomes between Salford Lung Study (SLS), an open-label effectiveness RCT,...
Background Chronic obstructive pulmonary disease exacerbations (acute exacerbation of chronic disease) are characterised by increased sputum volume, purulence and breathlessness. Patients encouraged to recognise treat acute as part a self-management plan. Only half caused bacterial infection, but plans generally advocate use antibiotics steroids for all events, hence may be overused. Sputum colour relates closely load; thus it could determine whether appropriate. This pragmatic randomised...