A5031412055- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Protease and Inhibitor Mechanisms
- Inflammation biomarkers and pathways
- Emergency and Acute Care Studies
- Frailty in Older Adults
- COVID-19 and Mental Health
- Immune cells in cancer
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Pulmonary Hypertension Research and Treatments
- S100 Proteins and Annexins
- Chronic Disease Management Strategies
- Respiratory and Cough-Related Research
- Pneumonia and Respiratory Infections
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nutrition and Health in Aging
- Pediatric health and respiratory diseases
University of Birmingham
2016-2025
University Hospitals Birmingham NHS Foundation Trust
2020-2025
Queen Elizabeth Hospital Birmingham
2011-2024
NIHR Birmingham Biomedical Research Centre
2020-2024
Health Data Research UK
2019-2024
Pioneer (United States)
2020-2024
National Institute for Health Research
2023-2024
NIHR Clinical Research Network
2024
Imperial College London
2022-2024
NIHR Applied Research Collaboration West
2024
Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with a range of persistent symptoms impacting everyday functioning, known as post-COVID-19 condition or long COVID. We undertook retrospective matched cohort study using UK-based primary care database, Clinical Practice Research Datalink Aurum, to determine that are confirmed SARS-CoV-2 beyond 12 weeks in non-hospitalized adults and the risk factors developing symptoms. selected 486,149 1,944,580...
Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect aging on neutrophil bactericidal responses, comparing function in healthy, young (23-35 years) and elderly (>65 volunteers. Superoxide generation response fMLP was slightly increased neutrophils from donors, serum able opsonize E. coli efficiently. In contrast, phagocytic index significantly lower elderly, compared with donors (P<0.005). CD11a CD11b expression not...
<h3>Rationale</h3> Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but not assessed risk for acute respiratory distress syndrome (ARDS). Causality of these associations never demonstrated. <h3>Objectives</h3> To determine if ARDS is associated with vitamin clinical setting to experimental models influences its severity. <h3>Methods</h3> Human, murine vitro primary alveolar epithelial cell work were included this study....
Neutrophil extracellular traps (NETs) are a recently discovered addition to the defensive armamentarium of neutrophils, assisting in immune response against rapidly dividing bacteria. Although older adults more susceptible such infections, no study has examined whether aging humans influences NET formation. We report that TNF-α-primed neutrophils generate significantly NETs than unprimed and lipopolysaccharide (LPS)- interleukin-8 (IL-8)-induced formation exhibits significant age-related...
Objective Vaping may increase the cytotoxic effects of e-cigarette liquid (ECL). We compared effect unvaped ECL to vapour condensate (ECVC) on alveolar macrophage (AM) function. Methods AMs were treated with ECVC and nicotine-free (nfECVC). AM viability, apoptosis, necrosis, cytokine, chemokine protease release, reactive oxygen species (ROS) release bacterial phagocytosis assessed. Results Macrophage culture or resulted in a dose-dependent reduction cell viability. was at lower...
<ns4:p>Airway neutrophilia is a common feature of many chronic inflammatory lung diseases and associated with disease progression, often regardless the initiating cause. Neutrophils their products are thought to be key mediators changes in airways patients obstructive pulmonary (COPD) have been shown cause pathological features disease, including emphysema mucus hypersecretion. Patients COPD also high rates bacterial colonisation recurrent infective exacerbations, suggesting that neutrophil...
Abstract Artificial intelligence as a medical device is increasingly being applied to healthcare for diagnosis, risk stratification and resource allocation. However, growing body of evidence has highlighted the algorithmic bias, which may perpetuate existing health inequity. This problem arises in part because systemic inequalities dataset curation, unequal opportunity participate research access. study aims explore standards, frameworks best practices ensuring adequate data diversity...
Chronic obstructive pulmonary disease (COPD) due to tobacco smoking commonly presents when extensive lung damage has occurred.
There are increased neutrophils in the lungs of patients with chronic obstructive pulmonary disease (COPD), but it is unclear if this due to inflammatory signal or related inherent behavior neutrophils. This critical, because inaccurate excessive neutrophil chemotaxis could drive pathological accumulation and tissue damage.To assess migratory dynamics isolated from COPD compared healthy smoking nonsmoking control subjects α(1)-antitryspin deficiency.Migratory structure were assessed...
Rationale: Population studies suggest improved sepsis outcomes with statins, but the results of randomized controlled trials in patients and organ dysfunction critical care settings have broadly been negative. In vitro data that statins modulate age-related neutrophil functions, improving responses to infection, only older at high doses.Objectives: To determine if high-dose simvastatin improves functions is safe tolerated hospitalized adults community-acquired pneumonia (CAP + S) not...
The COVID-19 pandemic serves as a potent reminder that older people are at very high risk of adverse outcomes from infectious disease because comorbidities associated with ageing and decreased immunological competence (immunosenescence). Care home residents particularly physiological vulnerability is compounded by cohabitation other frail adults, increasing exposure infection. Immunosenescence not only increases susceptibility to but also blunts the effectiveness vaccines1Lord JM effect...
Background Studies suggest that certain black and Asian minority ethnic groups experience poorer outcomes from COVID-19, but these studies have not provided insight into potential reasons for this. We hypothesised would be those of South ethnicity hospitalised a confirmed SARS-CoV-2 infection, once confounding factors, health-seeking behaviours community demographics were considered, this might reflect more aggressive disease course in patients. Methods Patients with infection requiring...
Rationale: Patients with chronic obstructive pulmonary disease (COPD) experience excess cardiovascular morbidity and mortality, exacerbations further increase the risk of such events. COPD is associated persistent blood airway neutrophilia systemic tissue hypoxia. Hypoxia augments neutrophil elastase release, enhancing capacity for injury. Objective: To determine whether hypoxia-driven protein secretion contributes to endothelial damage in COPD. Methods: The healthy human secretome generated...
Autoimmunity increases with aging indicative of reduced immune tolerance, but the mechanisms involved are poorly defined. In recent years, subsets B cells immunoregulatory properties have been identified in murine models autoimmune disorders, and these downregulate responses via secretion IL10. humans, immature transitional a CD19(+) CD24(hi) CD38(hi) phenotype reported to regulate IL10 production. We found frequency numbers were PBMC pool age. expression following activation either CD40, or...