A5025596285- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Voice and Speech Disorders
- Gastroesophageal reflux and treatments
- Ion Channels and Receptors
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Dysphagia Assessment and Management
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Diaphragmatic Hernia Studies
- Intensive Care Unit Cognitive Disorders
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- Receptor Mechanisms and Signaling
- SARS-CoV-2 and COVID-19 Research
- Blood Coagulation and Thrombosis Mechanisms
- Cystic Fibrosis Research Advances
- Neuropeptides and Animal Physiology
- COVID-19 and Mental Health
- Pulmonary Hypertension Research and Treatments
Queen's University Belfast
2016-2025
Royal Victoria Hospital
2009-2024
University of Ulster
2000-2024
Belfast Health and Social Care Trust
2015-2024
Duke University
2024
Imperial College London
2024
British Lung Foundation
2024
University of London
2024
London School of Hygiene & Tropical Medicine
2024
University of Ulsan
2023
Cough 1) All basic scientific articles should refer to cough as a three-phase motor act.For the purposes of acoustic recordings in clinical studies, however, be described forced expulsive manoeuvre or manoeuvres against closed glottis that are associated with characteristic sound sounds.
These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of hypersensitivity has allowed an umbrella term that explains exquisite sensitivity patients to external stimuli such a cold air, perfumes, smoke bleach. Thus, adults with now have firm physical explanation for their symptoms based on vagal afferent hypersensitivity. Different treatable traits exist variant asthma (CVA)/eosinophilic bronchitis responding anti-inflammatory...
### 1.1 Background Patients with cough frequently present to clinicians working in both primary and secondary care.1,2 Acute cough, which often follows an upper respiratory tract infection, may be initially disruptive but is usually self-limiting rarely needs significant medical intervention. Chronic the key symptom of many important chronic diseases sole presenting feature a number extrapulmonary conditions, particular airway gastrointestinal disease. Even clear diagnosis, can difficult...
<b>Background:</b> TORCH (Towards a Revolution in COPD Health) is an international multicentre, randomised, placebo-controlled clinical trial of inhaled fluticasone propionate/salmeterol combination treatment and its monotherapy components for maintenance moderately to severely impaired patients with chronic obstructive pulmonary disease (COPD). The primary outcome all-cause mortality. Cause-specific mortality deaths related are additional measures, but systematic methods ascertainment these...
In 2011, a European Respiratory Society Task Force embarked on process to determine the position and clinical relevance of cough hypersensitivity syndrome, disorder characterised by troublesome coughing often triggered low levels thermal, mechanical or chemical exposure, in management patients with chronic cough. A 21-component questionnaire was developed an iterative supported literature review. 44 key opinion leaders respiratory medicine were selected interviewed as their opinions. There...
Efficacy and safety of tiotropium+olodaterol fixed-dose combination (FDC) compared with the mono-components was evaluated in patients moderate to very severe chronic obstructive pulmonary disease (COPD) two replicate, randomised, double-blind, parallel-group, multicentre, phase III trials. Patients received FDC 2.5/5 μg or 5/5 μg, tiotropium 2.5 5 olodaterol delivered once-daily via Respimat inhaler over 52 weeks. Primary end points were forced expiratory volume 1 s (FEV1) area under curve...
Reports from individual centres suggest a preponderance of females with chronic cough. Females also have heightened cough reflex sensitivity. Here we reviewed the age and sex unselected referrals to 11 clinics. To investigate cause any observed dimorphism, functional magnetic resonance imaging putative was analysed in normal volunteers. The demographic profile consecutive patients presenting evaluated. Cough challenge capsaicin undertaken volunteers construct concentration-response curve....
Background The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed mediate inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However the limited clinical evidence for role of asthma or chronic obstructive pulmonary disease raises an alternative possibility that is promoted non-neuronal TRPA1. Methodology/Principal Findings By using Real-Time PCR calcium imaging, we found cultured human...
Chronic obstructive pulmonary disease (COPD) due to tobacco smoking commonly presents when extensive lung damage has occurred.
<h3>BACKGROUND</h3> Asthma, post-nasal drip syndrome (PNDS), and gastro-oesophageal reflux (GOR) account for many cases of chronic non-productive cough (CNPC). Each may simultaneously contribute to even when clinically silent, failure recognise their contribution lead unsuccessful treatment. <i>Methods</i>—Patients (all lifetime non-smokers with normal chest radiographs spirometric measurements) referred CNPC persisting more than three weeks as sole respiratory symptom underwent histamine...
Nonadherence to inhaled corticosteroid therapy (ICS) is a major contributor poor control in difficult asthma, yet it challenging ascertain.Identify test for nonadherence using fractional exhaled nitric oxide (Fe(NO)) suppression after directly observed (DOICS) treatment.Difficult asthma patients with an elevated Fe(NO) (>45 ppb) were recruited as adherent (ICS prescription filling >80%) or nonadherent (filling <50%). They received 7 days of DOICS (budesonide 1,600 μg) and based on changes...
More infants with bronchopulmonary dysplasia (BPD) now survive to adulthood, but little is known regarding persisting respiratory impairment. We report symptoms, lung function and health-related quality of life (HRQoL) in adult BPD survivors compared preterm (non-BPD) full-term controls. Respiratory symptoms (European Community Health Survey) HRQoL (EuroQol (EQ)-5D) were measured 72 (mean± sd study age 24.1±4.0 years; mean± gestational 27.1±2.1 weeks; birth weight 955±256 g) cared for the...
Rationale: Heightened cough responses to inhaled capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, are characteristic of patients with chronic cough. However, previously, TRPV1 antagonist (SB-705498) failed improve spontaneous frequency in these patients, despite small reductions capsaicin-evoked cough.Objectives: XEN-D0501 (a potent antagonist) was compared SB-705498 preclinical studies establish whether an improved efficacy profile would support further clinical trial...