A5074816400- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Voice and Speech Disorders
- Gastroesophageal reflux and treatments
- Ion Channels and Receptors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dysphagia Assessment and Management
- Respiratory Support and Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Respiratory viral infections research
- Neuroscience of respiration and sleep
- Infant Health and Development
- Pneumonia and Respiratory Infections
- Intensive Care Unit Cognitive Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Hormonal Regulation and Hypertension
- Legionella and Acanthamoeba research
- Long-Term Effects of COVID-19
- Olfactory and Sensory Function Studies
- Electrolyte and hormonal disorders
- Mechanical Circulatory Support Devices
- Poisoning and overdose treatments
- Tracheal and airway disorders
Albert Einstein College of Medicine
2016-2025
Montefiore Medical Center
2016-2025
Nationwide Children's Hospital
2023
Tokyo Medical and Dental University
2021
Center for Independent Living
2021
University of Valley Forge
2021
Helix (United States)
2021
Kaiser Permanente
2020
The Bronx Defenders
2001-2020
Hull York Medical School
2013-2014
Cough 1) All basic scientific articles should refer to cough as a three-phase motor act.For the purposes of acoustic recordings in clinical studies, however, be described forced expulsive manoeuvre or manoeuvres against closed glottis that are associated with characteristic sound sounds.
These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of hypersensitivity has allowed an umbrella term that explains exquisite sensitivity patients to external stimuli such a cold air, perfumes, smoke bleach. Thus, adults with now have firm physical explanation for their symptoms based on vagal afferent hypersensitivity. Different treatable traits exist variant asthma (CVA)/eosinophilic bronchitis responding anti-inflammatory...
In 2011, a European Respiratory Society Task Force embarked on process to determine the position and clinical relevance of cough hypersensitivity syndrome, disorder characterised by troublesome coughing often triggered low levels thermal, mechanical or chemical exposure, in management patients with chronic cough. A 21-component questionnaire was developed an iterative supported literature review. 44 key opinion leaders respiratory medicine were selected interviewed as their opinions. There...
Reports from individual centres suggest a preponderance of females with chronic cough. Females also have heightened cough reflex sensitivity. Here we reviewed the age and sex unselected referrals to 11 clinics. To investigate cause any observed dimorphism, functional magnetic resonance imaging putative was analysed in normal volunteers. The demographic profile consecutive patients presenting evaluated. Cough challenge capsaicin undertaken volunteers construct concentration-response curve....
The first confirmed case of novel coronavirus (2019-nCoV) infection in the United States was reported from state Washington January, 2020. By March, 2020, New York City had become epicenter outbreak States.We tracked all patients with coronavirus-19 (COVID-19) admitted to intensive care units (ICU) at Montefiore Medical Center (Bronx, NY). Data were obtained through manual review electronic medical records. Patients least 30 days follow-up.Our 300 ICU March 10 April 11, majority (60.7%) men....
Cough-variant asthma (CVA) occurs in a subgroup of asthmatics whose sole or predominant respiratory symptom is cough. Although bronchodilators are often sufficient to treat CVA, refractory cough may require therapy with inhaled systemic corticosteroids. In randomized, double-blind, placebo-controlled, crossover study, we examined the effect 14-day course leukotriene receptor antagonist zafirlukast on subjective score and cough-reflex sensitivity capsaicin eight subjects CVA beta agonists,...
Abstract Introduction To determine the optimal dose of sivopixant, a highly selective P2X3 receptor antagonist, for refractory or unexplained chronic cough (RCC/UCC). Methods In this phase 2b, randomized, double-blind, placebo-controlled, parallel-group, multicenter trial, patients received sivopixant 50, 150, 300 mg placebo once daily 4 weeks. The primary endpoint was change from baseline in 24-h frequency (coughs/h) with vs placebo. Results Overall, 390/406 randomized completed study....
ABSTRACT New treatment modalities are needed for the of infections due to multidrug-resistant Staphylococcus aureus. S. aureus capsular polysaccharide immune globulin (Altastaph) is a polyclonal preparation that being developed as adjunctive therapy persons with complicated by bacteremia. In phase II, multicenter, randomized, double-blind, placebo-controlled trial, 40 subjects documented bacteremia received standard plus either Altastaph at 200 mg/kg body weight in each two infusions 24 h...
Acute cough is one of the most common complaints prompting patient visits to healthcare professionals. Despite broad repercussions acute on quality life, school and work productivity, public health resources, research this condition minimal, as are available treatment options. Many patients use over-the-counter medicines, which often ineffective for symptom relief. Some therapies may achieve antitussive activity, but at expense unpleasant or intolerable side effects. When considering...