A5050972585- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Gastroesophageal reflux and treatments
- Allergic Rhinitis and Sensitization
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Ion Channels and Receptors
- Eosinophilic Esophagitis
- Lung Cancer Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Tuberculosis Research and Epidemiology
- Voice and Speech Disorders
- Sarcoidosis and Beryllium Toxicity Research
- T-cell and Retrovirus Studies
- Mycobacterium research and diagnosis
- Occupational and environmental lung diseases
- Drug Transport and Resistance Mechanisms
- Cancer Cells and Metastasis
- Respiratory Support and Mechanisms
- Medical Imaging and Pathology Studies
- Tracheal and airway disorders
Nagoya City University
2016-2025
Mizuho (Japan)
2013-2025
Nagoya City University Hospital
2013-2024
Nationwide Children's Hospital
2023
American Thoracic Society
2022
Nagoya Medical Center
2022
Kyoto University
2011-2021
Gunma University
2021
Juntendo University
2021
Hokuriku Electric Power Company (Japan)
2017-2020
Transient receptor potential vanniloid-1 (TRPV-1) mediates the cough response induced by pepper extract capsaicin and is expressed in sensory nerves that innervate airway wall. We determined expression of TRPV-1 airways patients with chronic persistent diverse causes an enhanced response. obtained mucosal biopsies fiberoptic bronchoscopy 29 16 healthy volunteers without a cough. Immunostaining for nerve profiles anti-protein gene product (PGP)-9.5 antibody showed no increase epithelium...
Dupilumab has clinical effects in patients with moderate-to-severe asthma. When considering interleukin (IL)-4 and IL-13 signaling, of dupilumab on airway mucus hypersecretion remodeling are expected, but they have been reported only a few short-term studies. Its efficacy for hyperresponsiveness (AHR) remains unknown. We comprehensively assessed the dupilumab, especially subjective objective measures dimensions asthmatic patients. In 28 adult uncontrolled asthma, comprehensive 48-week...
Postmortem studies have shown that airway wall thickening is present in asthmatic patients and may play a pathophysiologic role. We investigated the presence characteristics of with asthma, using helical computed tomography. Eighty-one 28 healthy control subjects were studied cross-sectionally. Airway thickness was assessed by validated method on basis area (WA), WA corrected body surface (WA/BSA), WA%, defined as (WA/total area) x 100 at apical bronchus right upper lobe. luminal (Ai) Ai/BSA...
Airway wall thickening has been assumed to cause airway hyperresponsiveness, but a protective effect against narrowing also suggested. We investigated the relationship between thickness as assessed by helical computed tomography and two components of responsiveness, sensitivity reactivity, in patients with stable asthma (n = 23) without 22) inhaled steroid treatment. A cross-section apical bronchus right upper lobe was obtained. area corrected body surface measured an index thickness....
Asthma is characterised by chronic inflammation of the airways, but relevance high-sensitivity assays for C-reactive protein (hs-CRP), which are known to be a sensitive marker low-grade systemic inflammation, has not been fully studied in asthma. The objective was examine serum hs-CRP levels patients with asthma and their relationship clinical characteristics degree airway inflammation. Serum were cross-sectionally examined steroid-naive (n = 22) steroid-inhaling 23) adult healthy controls...
Small airways play important roles in the pathophysiology of asthma. However, relationships between small airway involvement and health status dyspnea have not been investigated.It was aim this study to assess proximal peripheral functions status, disease control patients with asthma, using impulse oscillometry (IOS).We performed IOS, spirometry assessment (Asthma Quality Life Questionnaire St. George's Respiratory Questionnaire), (Baseline Dyspnea Index) Control Questionnaire) 65 asthmatics...
Abstract Purpose: The biologic characteristics of microenvironmental constituents, especially cancer-associated fibroblasts (CAF), can be key regulators the cellular sensitivity to molecular-targeted therapy. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have marked therapeutic effects against non–small cell lung cancer (NSCLC) with EGFR mutations, but some patients exhibited primary resistance EGFR-TKIs. We recently reported that podoplanin-positive are associated a...
Eosinophils are considered to play a central pathogenetic role in asthma. We previously reported that sputum eosinophilia was observed patients with cough variant asthma (CVA), as well "classic" wheezing. This study undertaken further investigate the involvement of eosinophils CVA. The serum eosinophil cationic protein (ECP) level, percentage bronchoalveolar lavage (BAL) fluid, and number bronchial biopsy specimen were examined 14 CVA, 21 classic asthma, seven healthy controls. For two...
Cough is one of the most frequent complaints for which patients seek medical care throughout world.1 The exact prevalence cough in Japan unknown, but UK, 10–15% entire population have a daily cough,2 and USA, over 100 million dollars are spent each year on treatment cough.3 aetiology ranges from self-resolving common cold to life-threatening cardiac disease lung cancer. Even if underlying has good prognosis, energy expended due decreases patient quality life (QOL). In addition being...
<b>Background:</b> Increased hydrogen and reduced chloride ionic environments of the airways are conducive to stimulation cough. However, constituents local milieu patients with chronic cough unknown. <b>Methods:</b> The pH levels in exhaled breath condensate capsaicin threshold (C5) were measured 50 16 healthy controls. measurements repeated after challenge those cause was asthma (n = 13), postnasal drip/rhinitis 7), gastro-oesophageal reflux 5), bronchiectasis but remained unidentified 20....
Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder. Afflicted patients show extreme sun-sensitivity and skin cancer predisposition. XP in most cases associated with deficient nucleotide excision repair (NER), which the process responsible for removing photolesions from DNA. Measuring NER activity by incorporation into patches, termed ‘unscheduled DNA synthesis (UDS)’, one of commonly used assays XP-diagnosis research. We have established a rapid accurate procedure...