A5018607947- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Advanced X-ray and CT Imaging
- AI in cancer detection
- Medical Image Segmentation Techniques
- Cancer therapeutics and mechanisms
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Medical Imaging and Pathology Studies
- Cancer Treatment and Pharmacology
- Lymphatic System and Diseases
- Atomic and Subatomic Physics Research
- Brain Tumor Detection and Classification
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Analysis
- Gastric Cancer Management and Outcomes
- Cancer Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Gyrotron and Vacuum Electronics Research
- Cancer Genomics and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
National Cancer Center Hospital East
2009-2018
Japan Clinical Cancer Research Organization
2015
Eli Lilly (United States)
2014
Ministry of Health Labour and Welfare
2014
National Cancer Centre Japan
1997-2012
Teikyo University
2008-2009
Tokushima University
1995-2009
Kyoto University Hospital
2009
Tokushima University Hospital
2009
Saiseikai Nakatsu Hospital
2008
PURPOSE: To compare low-dose spiral computed tomography (CT) with radiography of the chest for screening and detection small peripheral lung cancers in a high-risk population. MATERIALS AND METHODS: Posteroanterior lateral radiographs CT scans were obtained twice year from September 1993 to April 1995 1,369 individuals (a total 3,457 examinations) who at high risk cancer. Low-dose parameters 120 kvP, 50 mA, 10-mm collimation, 2:1 pitch. RESULTS: Peripheral cancer was detected 15 examinations...
PURPOSE: Because efficacy of lung cancer screening using chest x-ray is controversial and insufficient, other modalities need to be developed. To provide data on performance low-dose helical computed tomography (CT) scanning its in terms survival, a one-arm longitudinal project was conducted. PATIENTS AND METHODS: A total 1,611 asymptomatic patients aged 40 79 years, 86% with smoking history, were screened by CT scan, x-ray, 3-day pooled sputum cytology 6-month interval. RESULTS: At initial...
Objectives SN-38, an active metabolite of irinotecan, is detoxified by glucuronidation with UGT1A isoforms, 1A1, 1A7, 1A9, and 1A10. The pharmacogenetic information on haplotypes covering all these isoforms important for the individualized therapy irinotecan. Associations between pharmacokinetics/pharmacodynamics irinotecan were investigated to identify markers. Methods area under concentration curve ratio (SN-38 glucuronide/SN-38) or toxicities analyzed in 177 Japanese cancer patients...
IntroductionThe information regarding therapeutically relevant genomic alterations in small cell lung cancer (SCLC) is not well developed. We analyzed the SCLC genome using an integrative approach to stratify targetable alterations.MethodsWe performed whole exon sequencing (n = 51) and copy number analysis =47) on surgically resected tumors matched normal tissue samples from treatment-naive Japanese patients.ResultsThe demographics of 51 patients included this study were as follows: median...
Abstract Purpose: Although large-cell neuroendocrine carcinoma (LCNEC) of the lung shares many clinical characteristics with small-cell cancer (SCLC), little is known about its molecular features. We analyzed LCNECs to identify biologically relevant genomic alterations. Experimental Design: performed targeted capture sequencing all coding exons 244 cancer-related genes on 78 LCNEC samples [65 surgically resected cases, including 10 combined non–small cell (NSCLC) types separately, and...
Abstract Purpose: The biologic characteristics of microenvironmental constituents, especially cancer-associated fibroblasts (CAF), can be key regulators the cellular sensitivity to molecular-targeted therapy. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have marked therapeutic effects against non–small cell lung cancer (NSCLC) with EGFR mutations, but some patients exhibited primary resistance EGFR-TKIs. We recently reported that podoplanin-positive are associated a...
Objective: To clarify the progression of focal pure ground-glass opacity (pGGO) detected by low-dose helical computed tomography (CT) screening for lung cancer. Methods: A total 15,938 CT examinations were performed in 2052 participants project, and 1566 them judged to have yielded abnormal findings requiring further examination. Patients with peripheral nodules exhibiting pGGO at time first thin-section examination confirmed histologically after follow-up more than 6 months enrolled current...
Purpose We conducted a phase II study of single agent treatment with gefitinib in chemotherapy-naïve patients advanced non–small-cell lung cancer (NSCLC) to assess its efficacy and toxicity. Patients Methods received 250 mg doses daily. Administration was terminated if partial response (PR) not achieved within 8 weeks or tumor reduction observed 4 weeks. In these cases, platinum-based doublet chemotherapy given as salvage treatment. evaluated mutation status the epidermal growth factor...
Journal Article Phase I Study and Pharmacokinetics of CPT-11 With 5-Day Continuous Infusion Get access Yuichiro Ohe, Ohe * Department Internal Medicine, National Cancer Center HospitalTokyo, Japan *Correspondence to : M.D., Hospital, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104,Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yasutsuna Sasaki, Sasaki Tetsu Shinkai, Shinkai Kenji Eguchi, Eguchi Tomohide Tamura, Tamura Akira Kojima, Kojima Hiroshi Kunikane,...
Platinum-based two-drug combination chemotherapy has been standard of care for patients with advanced nonsmall-cell lung cancer (NSCLC). The primary aim was to compare overall survival (OS) NSCLC between the two regimens. Secondary end points included progression-free (PFS), response, safety, and quality life (QoL).Patients previously untreated stage IIIB or IV NSCLC, an Eastern Cooperative Oncology Group performance status 0-1 adequate organ function were randomized receive either oral S-1...
ObjectiveMagnesium supplementation has been reported to have a nephroprotective effect on cisplatin-induced renal dysfunction, but little evidence exists regarding the of magnesium preloading before cisplatin administration. We started include (8 mEq) in cisplatin-containing treatment regimens January 2011. The aim present study was evaluate whether reduces nephrotoxicity.
PURPOSE: To clarify the computed tomographic (CT) findings and progression of minute lung cancers that were missed at initial spiral CT screening but later detected. MATERIALS AND METHODS: The from seven patients with cancer was reviewed. Retrospective findings, time to detection, cell type, pathologic stage evaluated. RESULTS: Minute early included a nodule among shadows old tuberculosis (n = 2), faint high attenuation in center 1), an increase just adjacent axial peripheral pulmonary...
Thymic carcinoma is a rare neoplasm that often disseminates or metastasizes. The role of chemotherapy in treating this malignancy unclear. purpose the current study was to determine efficacy and tolerability weekly regimen consisting cisplatin, vincristine, doxorubicin, etoposide (CODE) for treatment advanced thymic carcinoma.The authors retrospectively reviewed 18 patients with who were treated between 1996 2002. Twelve these had unresectable diseases received according CODE regimen....
Characterization of pulmonary nodules plays a significant role in the differential diagnosis lung cancer. This paper presents method to quantify surface characteristics small with well-defined surfaces based on thin-section CT images. The segmentation three-dimensional (3-D) nodule images are obtained by 3-D deformable approach. feature extraction algorithms designed characteristic parameters from using curvatures and ridge lines. Experimental results authors' method, applied patients...
BACKGROUND In Japan, lung carcinoma is the leading cause of cancer-related deaths. Adenocarcinoma accounts for roughly half all carcinomas. Earlier detection expected to reduce mortality rates. Computed tomography (CT) provides higher contrast resolution and greater visualization chest compartments that are difficult view with radiography, such as mediastinum. CT further permits minute peripheral nodules. At present, several institutions research groups evaluating utility low dose spiral...
Following phase I studies of docetaxel and cisplatin in patients with non-small-cell lung cancer, the recommended doses were different for elderly (> or = 75 years) non-elderly (< patients. To elucidate mechanism difference, pharmacokinetics investigated two II separately conducted patients.Twenty-seven 25 treated three weekly administrations every 4 weeks. Doses 20 35 mg/m(2) patients, respectively. All received cisplatin. The pharmacodynamics compared patients.There no differences between...