A5049768782- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Immune Cell Function and Interaction
- Breast Cancer Treatment Studies
- Acute Myeloid Leukemia Research
- Cutaneous lymphoproliferative disorders research
- Breast Lesions and Carcinomas
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- T-cell and Retrovirus Studies
- Cancer and Skin Lesions
- Cancer, Hypoxia, and Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Ovarian cancer diagnosis and treatment
- Glioma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Gastrointestinal Tumor Research and Treatment
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
Tokyo National Hospital
2015-2024
National Cancer Center Hospital East
2011-2024
National Cancer Centre Japan
2013-2021
National Cancer Center
2008-2021
Experimental Pathology Laboratories
2012
Saga University
2008
Tochigi Cancer Center
2008
Takeda (Japan)
2008
Tokyo Medical Center
2008
National Hospital Organization
2008
Next-generation sequencing (NGS) of tumor tissue (ie, clinical sequencing) can guide management by providing information about actionable gene aberrations that have diagnostic and therapeutic significance. Here, we undertook a hospital-based prospective study (TOP-GEAR project, 2nd stage) to investigate the feasibility utility NGS-based analysis 114 cancer-associated genes (the NCC Oncopanel test). We examined 230 cases (comprising more than 30 types) advanced solid tumors, all which were...
The pathologic features of invasion such as stromal disruption and pleural/vascular involvement have been shown to be prognostic value in adenocarcinoma. However, the relationship between degree invasion, histologic subtype adenocarcinoma, prognosis remains unclear. We retrospectively studied 380 peripheral adenocarcinomas ≤2.0 cm diameter with regard histology clinical profiles. Their invasive growth was classified into four grades follows according structural deformity its location...
Purpose The image noise and quality of a prototype ultra-high-resolution computed tomography (U-HRCT) scanner was evaluated compared with those conventional high-resolution CT (C-HRCT) scanners. Materials Methods This study approved by the institutional review board. A U-HRCT 0.25 mm x 4 rows operating at 120 mAs used. C-HRCT images were obtained using 0.5 16 or 64 detector-row 150 mAs. Images from both scanners reconstructed 0.1-mm intervals; slice thickness for For scanners, display field...
Purpose To clarify the percentage of solitary pure ground-glass nodules (SPGGNs) 5 mm or smaller that grow and develop into invasive adenocarcinomas. Materials Methods This study was approved by institutional review board, informed consent obtained from all people who were screened. From February 2004 through December 2007, 7294 participants underwent screening for lung cancer with computed tomographic (CT) imaging. The nodule database reviewed to identify SPGGNs smaller. Growth evaluated as...
Phyllodes tumours are rare fibroepithelial of the breast, that include benign, borderline, and malignant lesions. Although molecular basis phyllodes largely remains unknown, a recent exome study identified MED12 mutations as sole recurrent genetic alteration in fibroadenoma, common benign tumour shares some histological features with tumour. Forty-six 58 fibroadenomas breast were analysed for by using Sanger sequencing. 37 out 46 (80%). The prevalence was similar among (15/18, 83%),...
Mutations of the epidermal growth factor receptor (EGFR), particularly deletional mutations (DEL) in exon 19 and L858R 21, are reportedly correlated with clinical outcome patients non–small cell lung cancer (NSCLC) receiving EGFR tyrosine kinase inhibitors gefitinib erlotinib, suggesting that detection would have an important role decision making. We established validated easy, inexpensive, rapid method for detecting DEL from cytologic material by high-resolution melting analysis (HRMA)....
Abstract BACKGROUND Several studies have shown the prognostic value of desmoplasia for lung adenocarcinomas. The authors evaluated density and extent by modifying scar grade, as well impact on patient survival. METHODS Modified grade was defined follows: Grade 1, no desmoplasia; 2, sparse desmoplastic reaction; 3, dense reaction with diameter 10 mm or less; 4, exceeding mm. In addition, conventional histologic factors modified analyzed in 239 cases small peripheral adenocarcinoma (maximum...
This study analysed incidence, patient outcome, immunophenotype and prognostic factors of histological transformation ( HT ) from extranodal marginal zone B‐cell lymphoma mucosa‐associated lymphoid tissue MALT lymphoma) to diffuse large DLBCL in 467 patients (median age, 61 years). The primary sites were the stomach (43%), ocular adnexa (25%), lung (8%), systemic (8%) other tissues (16%). occurred 8% lymphomas. Risk by 15 years was 5%: 4% limited‐stage diseases n = 385) 16% advanced‐stage...
Phyllodes tumors are rare fibroepithelial neoplasms of the breast, which carry potential risk local recurrence and metastasis. share several histological features with fibroadenomas, no widely accepted markers for distinguishing these lesions have been identified.We analyzed molecular abnormalities related to telomere elongation in tumors, including TERT promoter mutations, as well loss expression ATRX DAXX, a total 104 phyllodes fibroadenomas.Sequencing analyses showed that mutations were...
This was an observational study of Japanese participants who underwent low-dose computed tomographic (LDCT) lung cancer screening between February 2004 and March 2012, to evaluate the cancers in never-smokers smokers.The population consisted a total 12,114 subjects [never-smokers, 6,021 (49.70%); smokers with <30 pack-years smoking, 3,785 (31.24%); ≥30 2,305 (19.03%); unknown smoking status, 3 (0.02%)]. The odds ratio (OR) detection according status adjusted for age gender evaluated.A 152...
In lung cancer, somatic mutations of epidermal growth factor receptor ( EGFR ) are concentrated in exons 18–21, especially adenocarcinoma (Ad), but these have rarely been reported small cell carcinoma (SCLC). Combined SCLC is rare, and the mutation status its relationship to clinicopathological features this tumor type not yet elucidated. We retrospectively studied six patients with combined Ad components among 64 consecutive who underwent resection SCLC. The each patient were reviewed, for...
Abstract Objectives We aimed at investigating the relationship between classical Hodgkin lymphoma ( cHL ), primary mediastinal large B‐cell PMBL and gray zone GZL ) with intermediate characteristics , from perspective of aberration in programed cell death 1 ligands PDL s) network. Methods explored expression levels s chromosomal anomalies 67 cases: 34 cases 20 13 using immunohistochemical analyses Fluorescence In Situ Hybridization FISH ). Results Twenty‐one (62%), 3 (15%), 6 (46%) showed...
BackgroundAlthough primary ocular adnexal MALT (mucosa-associated lymphoid tissue ) lymphoma (POAML) is a recently recognized unique entity, its natural history, prognostic factors, behavior of progression and death, standard initial management have not been fully elucidated.
Abstract Context.—The lung is the most common site of metastasis during natural history malignant tumors. Breast carcinoma has a propensity for distant metastasis, and pleura are among metastatic sites. Although it often difficult to make clear-cut differential diagnosis between two, distinguishing primary from breast important because treatment modalities different. Objective.—To elucidate utility mammaglobin gross cystic disease fluid protein 15 (GCDFP-15), which known be breast-specific...
Identification of genetic alterations through next-generation sequencing (NGS) can guide treatment decision-making by providing information on diagnosis, therapy selection, and prognostic stratification in patients with hematological malignancies. Although the utility NGS-based genomic profiling assays was investigated malignancies, no sufficiently cover driver mutations, including recently discovered ones, as well fusions and/or pathogenic germline variants. To address these issues, here we...