A5058997514- Ocular Oncology and Treatments
- Renal Diseases and Glomerulopathies
- Corneal Surgery and Treatments
- Chronic Kidney Disease and Diabetes
- Cancer-related Molecular Pathways
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Lymphoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Brain Metastases and Treatment
- Vascular Tumors and Angiosarcomas
- CNS Lymphoma Diagnosis and Treatment
- Urological Disorders and Treatments
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Kidney Stones and Urolithiasis Treatments
- Colorectal Cancer Treatments and Studies
- Cancer and Skin Lesions
- Vasculitis and related conditions
- Ocular Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Melanoma and MAPK Pathways
- Urologic and reproductive health conditions
National Defense Medical College
1998-2025
Tokyo National Hospital
2016-2025
National Cancer Center
2004-2024
University of Tokyo Hospital
2024
National Institute for Japanese Language and Linguistics
2022
Juntendo University
1991-2015
National Cancer Center Hospital East
2005-2015
National Cancer Research Institute
2012
Tokyo Polytechnic University
2009
Ophthalmology Associates (United States)
2005-2007
PurposeTo present the American Brachytherapy Society (ABS) guidelines for plaque brachytherapy of choroidal melanoma and retinoblastoma.Methods MaterialsAn international multicenter Ophthalmic Oncology Task Force (OOTF) was assembled to include 47 radiation oncologists, medical physicists, ophthalmic oncologists from 10 countries. The ABS-OOTF produced collaborative guidelines, based on their eye cancer–specific clinical experience knowledge literature. This work reviewed approved by ABS...
Although an accurate uveal melanoma staging system is needed to improve research and patient care, the evaluation of eye cancer systems requires international multicenter data sharing acquire a statistically significant analysis.To assess mortality outcomes associated with according 7th edition American Joint Committee on Cancer's AJCC Cancer Staging Manual.A committee was formed create patient-specific fields for patients melanoma. Ten subspecialty ophthalmic oncology centers from 4...
PurposeTo assess of the effect local recurrence uveal melanoma on metastasis using a multicenter international tumor registry.DesignRetrospective study an online registry.ParticipantsPatients with diagnosed between 2001 and 2011.MethodsA committee was formed to create patient-specific data fields. Ten subspecialty ophthalmic oncology centers from 4 continents shared data. Patient selection criteria included diagnosis adequate records allow staging by American Joint Committee Cancer (AJCC)...
To compare central corneal thickness measurements taken with 3 pachymetry systems: Orbscan scanning-slit topography/pachymetry, Topcon SP2000P noncontact specular microscopy, and Tomey ultrasonic pachymetry.Multicenter study, Tokyo, Japan.In 216 healthy eyes of 114 subjects, topography, were used in that sequence to record thickness. In another 20 13 2 sets repeated for each assess repeatability.The mean was compatible between topography (546.9 micrometers +/- 35.4 [SD] ) (548.1 33.0...
HSP90 is involved in stability and function of cancer-related proteins. This study was conducted to define the MTD, safety, pharmacokinetics, pharmacodynamics, preliminary antitumor efficacy TAS-116, a novel class, orally available, highly selective inhibitor HSP90. Patients with advanced solid tumors received TAS-116 once daily (QD, step 1) or every other day (QOD, 2) 21-day cycles. Each comprised dose escalation phase determine MTD an expansion at MTD. In phase, accelerated dose-titration...
Objective To analyse ocular and systemic findings of patients presenting with metastasis. Methods analysis It is an international, multicentre, internet-enabled, registry-based retrospective data analysis. Patients were diagnosed between 2001 2011. Data included: primary tumour dimensions, extrascleral extension, ciliary body involvement, American Joint Committee on Cancer (AJCC)-tumour, node, metastasis staging, characteristics metastases. Results Of 3610 uveal melanoma, 69 (1.9%; 95% CI...
The majority of lymphomas in the ocular adnexa are low-grade B-cell mucosa-associated lymphoid tissue (MALT lymphoma). Although radiotherapy is most frequently applied management, cataract and dry eye problematic complications.Between 1973 2003, clinical features 36 patients with adnexal MALT lymphoma no symptoms who were managed initial therapy after biopsy or surgical resection retrospectively analyzed.The median patient age was 63 years (range 22-84) all had stage I disease, consisting 31...
Fasudil, a Rho-kinase inhibitor, may improve insulin signaling. However, its long-term effect on metabolic abnormalities and preventive diabetic nephropathy are still unknown. We assessed these effects of fasudil in insulin-resistant rats, comparing them with those an angiotensin II receptor blocker, olmesartan. Male Otsuka Long-Evans Tokushima fatty (OLETF) Otsuka, non-diabetic control, rats at 15 weeks age were used. OLETF randomized to receive low or high dose olmesartan for 25 weeks. To...
A nephritogenic antigen for acute poststreptococcal glomerulonephritis (APSGN) was isolated recently from group streptococcus and termed nephritis-associated plasmin receptor (NAPlr). In vitro experimental data indicate that the pathogenic role of NAPlr occurs through its ability to bind maintain proteolytic activity. However, mechanism whereby this induces glomerular damage in vivo has not been fully elucidated. Renal biopsy tissues 17 patients with APSGN, 8 rapidly progressive...
We evaluated the efficacy of nivolumab in patients with metastatic uveal melanoma previously untreated ipilimumab. performed a retrospective study at National Cancer Center Hospital Tokyo, Japan, where was approved 1 year earlier than Clinical outcomes were determined by assessing best overall response according to Response Evaluation Criteria Solid Tumors (version 1.1), progression-free survival and survival. Fourteen analyzed; none had received any prior systemic therapies although eight...
Objectives To evaluate the surgical and patient‐reported outcomes of YV‐plasty in patients with refractory bladder neck stenosis (BNS) following transurethral prostate surgery. Methods This retrospective study reviewed five who underwent for BNS between January 2021 October 2023. The procedure involved a midline lower abdominal incision to expose neck. A V‐shaped was made anterior wall create flap. then incised from apex V‐shape healthy urethra, forming Y‐shaped incision. Fibrotic tissue...
Objectives To evaluate the efficacy of staged urethroplasty for complex anterior urethral strictures from both surgical and patient‐reported outcome perspectives. Methods This retrospective study included 100 patients who underwent between May 2011 June 2023. Anatomical success was defined as ability to pass cystourethroscopy without resistance patient's void additional interventions. Patient‐reported outcomes were evaluated using validated questionnaires, including stricture surgery...
Objectives Limited data exist on surgical outcomes following artificial urinary sphincter (AUS) implantation in patients with a history of urethroplasty for urethral stricture. This study aimed to evaluate the AUS such patients, focusing risk erosion. Methods We retrospectively reviewed 14 male who developed severe incontinence stricture and subsequently underwent at our center between March 2012 January 2024. Patients either excision primary anastomosis (EPA) or non‐transecting anastomotic...
Perivascular epithelioid cell tumors (PEComas) rarely appear in the head and neck region. This case report describes two transcription factor E3 (TFE3)-rearranged PEComa cases, consisting of one orbit nasal cavity. Both cases demonstrated sheet-like or focal nested architecture comprised cells with abundant clear to eosinophilic cytoplasm vascular stroma. The first exhibited partial pleomorphism, a small necrosis area, slightly increased mitosis was classified as malignant. second mild...
To evaluate the feasibility and surgical outcomes of simultaneous urethral reconstruction for synchronous strictures (SUS) analyze techniques employed different stricture combinations. Twenty-two male patients with SUS who underwent between February 2018 July 2023 were retrospectively reviewed. Stricture locations lengths evaluated using cystoscopy urethrography after rest at least 3 months. Multiple based on characteristics, including anastomotic urethroplasty, substitution staged perineal...
ABSTRACT Objectives To evaluate the feasibility and surgical patient‐reported outcomes of nontransecting anastomotic urethroplasty (NTAU) for male patients with pelvic fracture urethral injury (PFUI) compared excision primary anastomosis (EPA), current mainstay approach. Methods This retrospective study analyzed 233 PFUI treated EPA ( n = 223) or NTAU 10) from 2008 to 2024 by a single surgeon (AH). involves preserving continuity maintaining bilateral bulbar artery integrity while excising...
ABSTRACT Objectives To compare the feasibility and outcomes of non‐transecting anastomotic urethroplasty (NTAU) with excision primary anastomosis (EPA) in management non‐traumatic posterior urethral stenosis (PUS). Methods We retrospectively reviewed 30 male patients who underwent for PUS between October 2013 July 2024. EPA was performed 15, NTAU 15. Surgical success defined as absence recurrent on cystourethroscopy without additional intervention. Patient‐reported outcomes, including lower...
BackgroundAlthough primary ocular adnexal MALT (mucosa-associated lymphoid tissue ) lymphoma (POAML) is a recently recognized unique entity, its natural history, prognostic factors, behavior of progression and death, standard initial management have not been fully elucidated.