A5048727238- Reconstructive Surgery and Microvascular Techniques
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Lymphatic System and Diseases
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Ear and Head Tumors
- Reconstructive Facial Surgery Techniques
- Head and Neck Surgical Oncology
- Organ and Tissue Transplantation Research
- Melanoma and MAPK Pathways
- Bone fractures and treatments
- Tumors and Oncological Cases
- Plant Virus Research Studies
- Genetic and rare skin diseases.
- Autoimmune and Inflammatory Disorders Research
- Vascular Procedures and Complications
- Systemic Sclerosis and Related Diseases
- Management of metastatic bone disease
- Dermatologic Treatments and Research
- Ocular Oncology and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Hedgehog Signaling Pathway Studies
- Sarcoma Diagnosis and Treatment
- Parvovirus B19 Infection Studies
Osaka Metropolitan University
2022-2023
Osaka City University
2020-2022
The University of Tokyo
2018-2021
National Cancer Center
2019-2020
National Cancer Center Hospital East
2020
Hiroshima University Hospital
2019
Abstract Treatment for patients with unresectable melanoma has been dramatically changed by the use of immunocheckpoint inhibitors (ICI). In this study, we reviewed stage III/IV melanoma, who were treated nivolumab between July 2014 and March 2017 at Department Dermatologic Oncology, National Cancer Center Hospital, Tokyo, retrospectively recorded cutaneous adverse events (cAE), development vitiligo, clinical characteristics responses. We identified 128 patients, 61 (47.7%) whom showed cAE,...
We evaluated the efficacy of nivolumab in patients with metastatic uveal melanoma previously untreated ipilimumab. performed a retrospective study at National Cancer Center Hospital Tokyo, Japan, where was approved 1 year earlier than Clinical outcomes were determined by assessing best overall response according to Response Evaluation Criteria Solid Tumors (version 1.1), progression-free survival and survival. Fourteen analyzed; none had received any prior systemic therapies although eight...
Abstract The efficacy and safety of nivolumab + ipilimumab combination therapy were retrospectively examined in Japanese patients with unresectable advanced melanoma clinical practice. Fifty‐seven received the therapy. primary site was cutaneous, mucosal, uveal unknown 35, 16, two four patients, respectively. overall response rate 26.3%, complete observed (3.5%) partial 13 (22.8%), stable disease 12 (21.1%) progressive 30 (52.6%). treatment‐naive prior systemic group 40.7% 13.3%, For those...
Abstract Extramammary Paget’s disease (EMPD) often invades the dermis and metastasizes to lymph nodes. Patients with EMPD associated node metastases have poor prognosis; date, effective treatment has not yet been established. Lymph dissection, aiming control local disease, is a standard form of management for patients (LNM). We investigated clinical pathological features, strategies prognostic factors metastatic who underwent dissection. retrospectively evaluated 38 cases extramammary...
Flow-through flaps, wherein two or more flaps are placed in series using microvascular anastomoses, indicated for the coverage of longer and wider defects, typically extremities.These technically demanding but, importantly, associated with distal flap loss.To overcome these problems, 'Orochi' concept placing multiple parallel as part a modular reconstruction has been put forward.In this article, is illustrated cases extremity use sequential triple thoracodorsal perforator (TAP)-intercostal...
Spinal cord metastasis of malignant melanoma is mostly caused by the invasion spinal melanoma. However, direct in rare and difficult to diagnose accurately. A few diagnostically valuable findings intramedullary metastases (ISCMs) have been published. a highly specific finding ISCMs all carcinomas 'rim sign', which signifies enhancement edge‑dominant effect lesion contrast‑enhanced MRI. The objective this case series was examine ratio with an indication rim signs present report describes two...
This case report demonstrates an important supermicrosurgical technique for lymphedema, which was established by Isao Koshima in 1994. So far, over 2,000 cases of limb edema have been treated this surgical method.
Linear scleroderma, a subtype of localized is rare disease that causes severe subcutaneous and deep tissue atrophy, which may result in considerable psychological burden for patients [1].
Lymphaticovenular anastomosis (LVA) using supermicrosurgical techniques is effective for treating and preventing progression of lymphedema. We analyzed the influence pregnancy on LVA in five patients from a total 2179 cases. Previous studies offer conflicting reports whether worsens pre-existing This first report lower limb lymphedema previously treated by multisite (mLVA). Five with primary (n=4) secondary (n=1) leg were this study. Patient age ranged 18 to 31 (average 22.6) years old 4...
Citation: Mizuta H, Nakano E, Yamazaki N. Primary cutaneous Rosai-Dorfman disease of the scalp. Dermatol Pract Concept. 2021;11(1):e2020086. DOI: https://doi.org/10.5826/dpc.1101a86
Received: 20 July 2022 Accepted after revision: 07 February 2023 Manuscript online:21
When reconstructing a congenital floating thumb, we describe two children in whom preservation of all five digits is achieved through successful transfer thoracodorsal artery perforator (TAP) flap and vascularized scapula. The main problem dealing with pouce flottant, or to select donor site for skeletal soft tissue reconstruction children. Although thumb (type Ⅳthumb hypoplasia) usually managed pollicization because the postoperative function thought be excellent, there are occasions when...
近年，ニボルマブ・イピリムマブ併用療法が悪性黒色腫に対する承認を受け，免疫チェックポイント阻害薬単剤よりも高い奏効率を示している。しかしながら，重篤な免疫関連有害事象（immuno−related adverse event：irAE）の頻度も高く，特に下垂体炎は単剤より併用療法での発症率が高いとされている。我々はニボルマブ・イピリムマブ併用療法後の下垂体炎について検討した。悪性黒色腫に対するニボルマブ・イピリムマブ併用療法による下垂体炎と確定診断した症例は3例であった。ニボルマブ・イピリムマブ併用療法を行った24例の内，15例（62.5％）でCommon Terminology Criteria for Adverse Events v5.0（CTCAE）grade...
Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma. This condition difficult to diagnose because its large size and expansive nature may be diagnosed as malignant tumor. There are various treatments such surgery oral retinoids; however, limited studies have verified their effectiveness. Here, we report case KCM on the anterior chest 50-year-old woman evaluate efficacy retinoids. In this case, retinoids were highly effective for treatment. A total 55 cases KCM,...
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Pathological complete response to preoperative
A 67-year-old man had a tumor on his right cheek. It was resected 15 years earlier but recurred 1 year before first visit. He red papule cheek and subcutaneous induration in the preauricular area. biopsy revealed mucinous carcinoma. The positron emission tomography-computed tomography showed accumulation only parotid gland lymph node; therefore, we diagnosed primary cutaneous Sentinel lymphoscintigraphy of level II node. underwent extended resection sentinel-node biopsy. Both nodes were...