A5102012453- Reconstructive Surgery and Microvascular Techniques
- Lymphatic System and Diseases
- Diagnosis and Treatment of Venous Diseases
- Reconstructive Facial Surgery Techniques
- Vascular Malformations and Hemangiomas
- Lymphatic Disorders and Treatments
- Bone fractures and treatments
- Urological Disorders and Treatments
- Organ and Tissue Transplantation Research
- Sympathectomy and Hyperhidrosis Treatments
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Treatments and Mutations
- Urinary and Genital Oncology Studies
- Vascular Procedures and Complications
- Glycosylation and Glycoproteins Research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Nerve Injury and Rehabilitation
- Body Contouring and Surgery
- Wound Healing and Treatments
- Pancreatic function and diabetes
- Surgical site infection prevention
- Trauma Management and Diagnosis
- Ureteral procedures and complications
- Surgical Simulation and Training
Kawasaki Medical School
2024
The University of Tokyo
2005-2023
Kawasaki Medical School Hospital
2023
Tokyo Medical University
2019-2021
University of Tokyo Hospital
2015-2021
Creative Commons
2020-2021
Kobe City Medical Center West Hospital
2018-2020
Hiroshima University Hospital
2019
Queen Mary University of London
2018
Keio University Hospital
2017
Background Lymph node dissection is often performed as a part of surgical treatment for breast cancer and malignant melanoma to prevent cells from traveling via the lymphatic system. Currently little known about postoperative drainage pattern alterations. This knowledge may be useful management recurrent prevention related lymphedema. We mapped complete superficial system dog used this canine model perform preliminary studies architectural changes in condition. Methods Lymphatic territories...
Background: Recently, a superthin “pure skin perforator” flap without any subcutaneous tissue was proposed, but the vascularity is still unclear. The authors therefore investigated of proposed superficial circumflex iliac artery–pure perforator along with its clinical applications and findings on indocyanine green imaging. Methods: locations dimension 70 pure perforators 40 flaps were classified into central-peripheral mediolateral parts. Indocyanine angiography used to analyze patterns...
Abstract Context.—Idiopathic pulmonary fibrosis (IPF) is characterized by diffuse interstitial inflammation and fibroblast proliferation with accelerated remodeling of extracellular matrix, which r...
Abstract Context.—Idiopathic pulmonary fibrosis (IPF) is characterized by diffuse interstitial inflammation and fibroblast proliferation with accelerated remodeling of extracellular matrix, which result in irreversible destruction the lung's architecture. Objective.—To elucidate production levels, tissue localization, activation matrix metalloproteinase 7 (MMP-7) lungs patients IPF. Design.—Bronchoalveolar lavage analysis was performed 17 IPF 6 healthy volunteers. Levels MMP-7 blood were...
The mechanism of anti-tumour activity by BCG is not known clearly. However, many studies suggest that immunological response related to effectiveness intravesical instillation in the therapy for superficial bladder carcinoma. Peripheral blood mononuclear cells (PBMC), urine and serum were obtained from patients with carcinoma at various times during course instillation. Urine showed increased levels IL-1beta, IL-2, IL-6, tumour necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma)...
New flow-through perforator flaps with a large, short vascular pedicle are proposed because of their clinical significance and high success rate for reconstruction the lower legs. Of 13 consecutive cases, authors describe two cases successful transfer new short-pedicle anterolateral or anteromedial thigh flap coverage soft-tissue defects in This has thin fatty layer small fascial component, is vascularized originating from segment descending branch lateral circumflex femoral system. The...
Delayed wound healing in lymphedema is assumed to be caused by two reasons, pathophysiological and immunological effects of lymphedema. The aim this review establish how impaired lymphatics alter pathophysiologically immunologically, propose treatment modalities that can promote Lymphaticovenular anastomoses (lymphovenous [LVAs]) were performed on patients who had recurrent cellulitis several times with lymphorrhea developed severe ulcers refractory skin grafts, flaps, conservative therapy....
The authors describe, in the first report of this type replantation surgery, a high success rate using delayed venous anastomosis 16 consecutive distal phalangeal replantations under digital block. Among these replantations, seven fingers (43.8 percent) showed postoperative congestion and five were reoperated on with drainage All successfully drained by additional single or double vein graft. As result, 13 survived (81.3 percent rate). operations performed
The purpose of this study was to determine the usefulness a new flap model, superficial inferior epigastric artery (SIEA) for supermicrosurgical training. Experimental groups were randomly divided into three 10 rats each. In each group SIEA flaps elevated and then returned their original locations with or without vascular anastomosis vessels. Group 1: free flap, 2: 1 hour ischemia time, 3: 4 hours 4: anastomosis. viability rate 80% 1, 50% 2, 40% 3. All nonvascularized (group 4) underwent...
The anatomical variations in accessory lymphatic pathways around the axillary region may work as a drainage route for excess fluid accumulation secondary upper extremity lymphedema. In this report, extending to shoulder, neck, and breast regions lymphedema patients are shown using indocyanine green (ICG) lymphography.Between January 2012 May 2015, 30 limbs of 29 with after malignant tumor resection were evaluated. ICG lymphography was performed chronic formation.Of limbs, identified across 3...
We established the Microvascular Research Center Training Program (MRCP) to help trainee surgeons acquire and develop microsurgical skills. Medical students were recruited undergo MRCP assess effectiveness of for surgeons.Twenty-two medical with no prior experience, who completed course from 2005 2012, included. The comprises 5 stages training, each specific passing requirements. Stages 1 2 involve anastomosing silicone tubes blood vessels chicken carcasses, respectively, within 20 minutes....
Abstract Background Pembrolizumab is effective as first-line therapy against advanced non-small cell lung cancer (NSCLC) in patients with programmed death ligand-1 (PD-L1) expression levels ≥50% [1]. However, it not all patients, and the factors predicting responses among this population remain unknown. Methods We retrospectively analyzed NSCLC a PD-L1 tumor proportion score (TPS) > 50%, who received monotherapy pembrolizumab from February 1, 2017 to April 30, 2018. The study included 11...
Indocyanine green lymphography has recently been used to assess lymphatic vessel function in lymphedema patients. Postoperative collateral vessels toward ipsilateral axillary lymph nodes are rarely seen above the umbilical level lower Between January 2012 and December 2014, we performed indocyanine of 192 limbs 96 extremity cases. As a result, dermal back flow appeared 95 cases, with 38 abdominal area 31 genital area. We confirmed 3 cases superficial ways extending nodes. All had similarity...
Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High expression ALDHs is marker for stem cells many organs including the lungs. A common polymorphism ALDH2 gene (ALDH2*2) results inactivation enzyme and associated with alcohol flushing syndrome increased risk cardiovascular Alzheimer's diseases some cancers. The effect this on lung its has not been thoroughly examined. We examined association between ALDH2*2 allele function parameters population healthy...
Although patients with obesity-induced lymphedema can be treated by weight loss therapy, they find it difficult to lose the required amount of weight. The aims this study were clarify characteristics lymphatic vessels in and determine feasibility efficacy lymphovenous anastomosis (LVA) these patients.Twenty-two (44 edematous lower limbs) a body mass index (BMI) >35 kg/m2 (obese group) 91 (141 BMI <25 enrolled as control group (nonobese underwent LVA. diameter depth lymphatics effect LVA...
Abstract Wearable sensors have seen remarkable recent technological developments, and their role in healthcare is expected to expand. Specifically, monitoring tissue circulation patients who undergone reconstructive surgery critical because blood flow deficiencies must be rescued within hours or the transplant will fail due thrombosis/haematoma artery vein. We design a wearable, wireless, continuous, multipoint sensor monitor circulation. The system measures pulse waves, skin colour,...