A5005085013- Muon and positron interactions and applications
- Fusion materials and technologies
- Semiconductor materials and devices
- Particle accelerators and beam dynamics
- Ammonia Synthesis and Nitrogen Reduction
- Copper Interconnects and Reliability
- Synthesis and Biological Evaluation
- Atomic and Molecular Physics
- ZnO doping and properties
- Graphene research and applications
- GaN-based semiconductor devices and materials
- Metal and Thin Film Mechanics
- Neuroendocrine regulation and behavior
- Synthesis and Reactions of Organic Compounds
- Nuclear Materials and Properties
- Advanced MRI Techniques and Applications
- Diamond and Carbon-based Materials Research
- Cardiac Imaging and Diagnostics
- Ion-surface interactions and analysis
- Receptor Mechanisms and Signaling
- Eicosanoids and Hypertension Pharmacology
- Advancements in Battery Materials
- Pharmacological Effects and Assays
- Intermetallics and Advanced Alloy Properties
- High-Temperature Coating Behaviors
Kindai University
2025
Nagoya University
2025
Kyoto Notre Dame University
2024
Kyoto University
1991-2024
Kyoto University Research Reactor Institute
2017-2023
RELX Group (Netherlands)
2023
Iwate Medical University
2021
Showa University
2021
Jikei University School of Medicine
2021
The Japanese Society of Gastroenterological Surgery
2021
Ischemic preconditioning slows ATP depletion and ultrastructural damage during the final episode of ischemia. To define influence creatine phosphate (CP) intracellular pH (pHi) on this effect, CP pHi were serially measured in porcine hearts without collateral circulation by using 31P-NMR spectroscopy examination.Farm pigs weighing 12-15 kg anesthetized with Fluothane. The control group underwent a single occlusion (20 minutes or 60 minutes); preconditioned four episodes 5-minute reperfusion...
Solute-free water diuretics (aquaretics) by antagonizing hydrosmotic vasopressin receptors (V2) may be useful in treating water-retaining diseases. The effects of intravenous administration a newly developed nonpeptide, selective V2 antagonist, OPC-31260, at doses ranging from 0.017 to 1.0 mg/kg groups healthy, normally hydrated men were compared with those 0.33 furosemide and placebo. OPC-31260 increased the hypotonic urine volume dose dependently for first 4 h, while induced sodium...
BACKGROUND It has been reported that a brief period of coronary occlusion and reperfusion slows the rate ATP depletion during subsequent sustained ischemia as well limiting infarct size. However, it not yet determined whether ischemic preconditioning also an effect on functional metabolic recovery stunned myocardium. Our study was designed to address this problem. METHODS AND RESULTS Farm pigs were anesthetized with fluothane randomly assigned either control group or preconditioned group....
The β‐adrenoceptor stimulant properties of 5‐(1‐hydroxy‐2‐isopropylaminobutyl)‐8‐hydroxycarbostyril hydrochloride hemihydrate (OPC‐2009) were compared with those isoprenaline and salbutamol on guinea‐pig isolated tissues. In producing tracheal relaxation, OPC‐2009 was approximately 7 times more potent 5 less than isoprenaline. Both compounds in increasing either the rate beating right atria or contractile force left atria, being 4 127 100 700 respective preparations. Selectivity calculated...
Intellectual disability (ID) is a neurodevelopmental disorder (NDD) characterized by impairments in intellectual and adaptive functioning, highly co-morbid with other NDDs. Recently, de novo missense variants the gene, CAMK2A, which encodes calcium/calmodulin-dependent protein kinase IIα (CaMKIIα), an abundant neuronal crucial for synaptic plasticity, learning memory, have been implicated ID. However, causative impact of these mutations remains underexplored. In this study, we developed...
1. The homogeneity of beta-adrenoceptors in femoral, superior mesenteric and renal vascular beds was investigated by the use regional perfusion technique dogs. 2. Isoprenaline salbutamol produced dose-related increases femoral blood flow. dose-response curves for two agonists were parallel, but approximately 1/15 as potent isoprenaline on a weight basis. 3. increased flow manner. However, 1/240 basis, slope curve less steep than that isoprenaline. 4. to increase shifted right intravenous...
Abstract Positron annihilation spectroscopy was used to investigate vacancy-type defects in diamond-like carbon (DLC) films. From Doppler broadening measurements of the γ -rays produced by and positron lifetime (PAL) using a slow beam on DLC films deposited various deposition methods conditions, it found that there is good correlation between S parameter obtained PAL. The result PAL correlates well with film density hardness, indicating can be as an indicator these properties. hydrogen...
The Doppler broadening of annihilation radiation (DBAR) spectra Fe, Co, Ni, and Gd polycrystals measured using spin-polarized positrons from a $^{68}\mathrm{Ge}$-$^{68}\mathrm{Ga}$ source in magnetic fields exhibited clear asymmetry upon field reversal. differential DBAR between field-up field-down conditions were qualitatively reproduced calculations considering polarization electrons. magnitudes the field-reversal for Ni samples was approximately proportional to effective magnetization....
First-principles calculations related to defect complexes formed from a monovacancy and multiple interstitial impurity atoms (hydrogen, carbon, nitrogen, oxygen atoms) in tungsten were performed. The most stable atomic configurations, the electron density distributions, binding energies of atoms, positron lifetimes each complex calculated. In calculating lifetimes, slight deviations initial positions H found be enhanced by localization, which affected vacancy-hydrogen complexes. addition,...
A series of 4-substituted 8-[(2-benzimidazolyl)sulfinylmethyl]-1,2,3,4-tetrahydroquinolin es was synthesized and examined for their (H+ + K+)adenosine triphosphatase (ATPase)-inhibitory antisecretory activities against histamine-induced gastric acid secretion in rats. Many compounds tested were potent inhibitors K+)ATPase. Most showed activity. The antiulcer activity water-immersion stress-induced ulcer, aspirin-induced ulcer necrosis induced by hydrochloric also the rat. Some these...
We measured the Doppler broadening of annihilation radiation (DBAR) spectra $3d$ (Fe, Co, and Ni) $4f$ (Gd, Tb, Dy) ferromagnets under a magnetic field by using spin-polarized positrons from ${}^{68}$Ge-${}^{68}$Ga source. The results showed that DBAR these metals have notably different magnetic-field dependences. differences among Fe, Ni reflect upper minority spin bands Fe Co are nearly empty while those still mostly occupied. For rare-earth instead inner electrons, $5d$ electrons mediate...
We studied the hypotensive effects of OPC-21268, an orally effective nonpeptide vasopressin V1 receptor antagonist, in spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP). OPC-21268 was given intravenously to conscious, freely moving SHRSP. used young aged animals examine contribution development maintenance hypertension both types rats. In SHR, fully established at 38 weeks age, intravenous injection produced slight either or 70 age. SHRSP, developed 25 blood pressure...
Cilostazol, an antiplatelet drug, and probucol, a cholesterol-lowering are reported to ameliorate atherosclerosis in animal models. However, their combined effect on is unclear. We therefore evaluated atherosclerotic lesions LDL receptor-deficient mice. Male mice were fed high fat diet with or without cilostazol alone, probucol combination, for 8 weeks. Body weight plasma lipid levels measured before during treatment. At the end of treatment, size distribution lipoproteins was analyzed by...
We investigated whether transient adenosine (Ado) infusion before ischemia had the same effect on myocardial metabolism and function as ischemic preconditioning (IP). The control (C) group underwent 15 min of coronary artery occlusion followed by 120 reperfusion. Ado received a 15-min (200 micrograms.kg-1.min-1) into left atrium starting 20 ischemia. IP was elicited two cycles 5-min In area at risk, tissue levels ATP, creatine phosphate (CP), intracellular pH (pHi) were serially measured...