A5034238510- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- Infectious Diseases and Mycology
- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Infectious Diseases and Tuberculosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- SARS-CoV-2 detection and testing
- COVID-19 and healthcare impacts
- Pneumocystis jirovecii pneumonia detection and treatment
- Cystic Fibrosis Research Advances
- Helicobacter pylori-related gastroenterology studies
- Antifungal resistance and susceptibility
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Urban and spatial planning
- Quinazolinone synthesis and applications
- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
Keio University
2016-2025
Keio University Hospital
2016-2025
Yokohama Rosai Hospital
2011-2024
Meijo University
2010-2024
Kinjo Gakuin University
2024
Japan Society of Chemotherapy
2019-2024
Japanese Society for Dialysis Therapy
2018-2023
Tokyo Medical and Dental University
2009-2022
National Hospital Organization
2007-2022
Tokyo Medical Center
2022
This study was performed to examine the putative role of high mobility group box (HMGB) protein in pathogenesis acute lung injury (ALI). Observations were made (1) 21 patients who septic with ALI and 15 normal function (2) a mouse model 24 hours after intratracheal instillation lipopolysaccharide (LPS). The concentrations HMGB1 increased plasma epithelial lining fluid mice instilled LPS. LPS-induced mitigated by anti-HMGB1 antibody. Although this not detected control humans or mice,...
Rationale: Improved therapeutic options are needed for patients with treatment-refractory nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex (MAC). Objectives: To evaluate the efficacy and safety of daily amikacin liposome inhalation suspension (ALIS) added to standard guideline-based therapy (GBT) in refractory MAC disease. Methods: Adults amikacin-susceptible MAC-positive sputum cultures despite at least 6 months stable GBT were randomly assigned (2:1) receive...
Section:ChooseTop of pageAbstract <<MATERIALS AND METHODSRESULTSDISCUSSIONReferencesCITING ARTICLES
KL-6 is a pulmonary epithelial mucin more prominently expressed on the surface membrane of alveolar type II cells when these are proliferating, stimulated, and/or injured. We hypothesized that high levels in lining fluid and plasma would reflect severity lung injury patients with acute (ALI). Epithelial was obtained at onset ( day 0) 1 respiratory distress syndrome (ARDS)/ALI by bronchoscopic microsampling procedure 35 patients. On 0, albumin concentrations were significantly higher than...
Rationale: The management of macrolide-resistant Mycobacterium avium complex (MR-MAC) pulmonary disease is difficult and thought to be analogous that multidrug-resistant tuberculosis (MDR-TB).Objectives: This study aimed clarify the cause MR-MAC, see how its affected outcome, compare prognosis with MDR-TB.Methods: medical records 102 consecutive cases MR-MAC at three tertiary hospitals for mycobacteriosis in metropolitan Tokyo one Aichi prefecture from 2005 2014 were reviewed. data 311...
Since 2010, mycobacterial examination results have been used widely to survey nontuberculous mycobacteria (NTM) lung disease.To reveal the clinical and epidemiological status of NTM disease in Japan.All data on isolation identification 2012 2013 were obtained from three dominant commercial laboratories Japan. Pulmonary was defined basis bacteriological diagnostic criteria issued by American Thoracic Society/Infectious Diseases Society America. The coverage population estimated using ratio...
Presence of Mycobacterium fortuitum in respiratory tracts usually indicates mere colonization or transient infection, whereas true pulmonary infection occurs patients with gastroesophageal disease. However, little is known about the diagnostic indications for M. and natural history disease.A 59-year-old man was referred to our hospital treatment against infection. Fifteen years before referral, he underwent total gastrectomy, after which experienced esophageal reflux symptoms. After patient...
Increased levels of proteases, such as trypsin, in the distal intestine have been implicated intestinal pathological conditions1-3. However, players and mechanisms that underlie protease regulation lumen remained unclear. Here we show Paraprevotella strains isolated from faecal microbiome healthy human donors are potent trypsin-degrading commensals. Mechanistically, recruit trypsin to bacterial surface through type IX secretion system-dependent polysaccharide-anchoring proteins promote...
We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization Japan, by COVID-19 waves, from conventional strains Delta variant.We used secondary data a database and performed retrospective cohort study that included 3261 aged ≥ 18 years enrolled 78 hospitals participated Japan Task Force between February 2020 September 2021.Patients hospitalized during second (mean age, 53.2 [standard deviation {SD}, ± 18.9]) fifth...
Bronchiectasis is characterised by uncontrolled neutrophil serine protease (NSP) activity. Cathepsin C (CatC; dipeptidyl peptidase 1) activates NSPs during maturation. CatC inhibitors can potentially reduce neutrophil-mediated lung damage. This Phase II, randomised, double-blind, placebo-controlled trial (AIRLEAF®; NCT05238675 ) evaluated efficacy, safety and optimal dosing of BI 1291583, a novel, reversible inhibitor, in adults with bronchiectasis. In total, 322 participants were randomised...
CysLT1 antagonists are effective for a subset of patients with asthma; however, there has been no good way to predict given patient's response. We examined the interaction between clinical response cysLT1 antagonist, pranlukast, and DNA sequence variant A(-444)C in leukotriene C4 synthase (LTC4S) gene Japanese moderate asthma. The frequency LTC4S C(-444) allele was 21.6% general population (n = 171) 19.4% asthmatic subjects 349). A 4-week prospective, open trial pranlukast (225 mg twice...
The interaction of receptor for advanced glycation end products (RAGE) and its ligands often leads to inflammatory processes or tissue injury, although the effect blockade RAGE signaling on lung injury remains be investigated.Using a murine model induced by intratracheal lipopolysaccharide (LPS), we evaluated expression in airspace recombinant soluble (sRAGE) LPS-induced injury.First, sRAGE bronchoalveolar lavage (BAL) fluid was determined at 24 hours after instillation LPS...
A small GTPase, Rho, plays key roles in cell adhesion, motility, and contraction after stimulation. Among Rho effectors isolated, the family of Rho-associated coiled-coil-forming protein kinases (ROCK) is implicated Rho-mediated adhesion smooth muscle contraction. The effect a specific inhibitor ROCK, Y-27632, was evaluated murine model acute lung injury induced by intravenous injection Escherichia coli endotoxin (lipopolysaccharide [LPS]). Lung edema measuring extravascular leakage...
Sepsis is a serious medical condition that requires rapidly administered, appropriate antibiotic treatment. Conventional methods take three or more days for final pathogen identification and antimicrobial susceptibility testing. We organized prospective observational multicenter study in sites to evaluate the diagnostic accuracy potential clinical utility of SeptiFast system, multiplex detection system used setting support early diagnosis bloodstream infections.A total 212 patients,...
Rationale: The epidemiology of nontuberculous mycobacterial pulmonary disease (NTM-PD) remains unclear in the majority countries, including Japan.Objectives: To estimate nationwide incidence and prevalence NTM-PD Japan to describe case characteristics geographical variation.Methods: In this cross-sectional study, we analyzed data from all health insurance claims made for collected National Database between 2009 2014. A patient with was identified on basis at least one claim submitted...
Headache is an adverse event of coronavirus 2019 (COVID-19) vaccination. Whether patients with history headache suffer more from vaccination-induced headaches unknown. We aimed to uncover if develop after COVID-19 mRNA vaccination than healthy controls.We performed a questionnaire survey for nursing staff in our hospital April May 2021. Based on baseline characteristics, we divided the participants into migraine, non-migrainous headache, and control, examined occurrence features...
Abstract We report a 330 ppi monolithic RGB micro light-emitting diodes ( μ LED) array of blue, green and red GaInN-based LEDs stacked on the same wafer. Considering it is challenging to form ohmic electrodes plasma-etched p-type GaN surface, tunnel junctions were used connect each LED, anode for blue formed n-type AlGaN. The fabricated LED arrays tested at room temperature (approximately 26 °C) DC. Each emitted with peak wavelengths 486, 514 604 nm current density 50 A cm −2 .
New therapies are needed to prevent exacerbations, improve quality of life and slow disease progression in bronchiectasis. Inhibition cathepsin C (CatC) activity has the potential decrease activation neutrophil-derived serine proteases patients with bronchiectasis, thereby reducing airway inflammation, improving symptoms, exacerbations preventing further damage. Here we present design a phase 2 trial (Airleaf™; NCT05238675 ) assessing efficacy safety novel CatC inhibitor, BI 1291583, adult...
In coping with severe acute respiratory syndrome (SARS), infection control measures are a key aspect of protecting healthcare workers. We conducted survey concerning perception risk and countermeasures for SARS in 7 tertiary hospitals Japan from July through September 2003, immediately after the epidemic neighboring countries. Based on 7,282 respondents out 9,978 questionnaires administered, we found to be relatively high at institutional level low. Knowledge preventive measures, concept...