A5081302173- Silicon Nanostructures and Photoluminescence
- Semiconductor materials and devices
- Anesthesia and Pain Management
- Respiratory Support and Mechanisms
- Nanowire Synthesis and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Semiconductor Quantum Structures and Devices
- Thin-Film Transistor Technologies
- Sepsis Diagnosis and Treatment
- Nausea and vomiting management
- Anesthesia and Sedative Agents
- Spine and Intervertebral Disc Pathology
- Neonatal Respiratory Health Research
- Semiconductor materials and interfaces
- Pain Management and Opioid Use
- Ion-surface interactions and analysis
- Pain Mechanisms and Treatments
- Advancements in Semiconductor Devices and Circuit Design
- Tracheal and airway disorders
- TiO2 Photocatalysis and Solar Cells
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
Keio University
2016-2025
Keio University Hospital
2011-2023
Kanazawa University
2016-2019
Aichi University of Education
2015
Hiroshima University
2010-2014
Marymount University
2001-2009
Genentech
2009
Daikin (United States)
2008
University of Electro-Communications
1996-2006
Ono Pharmaceutical (Japan)
2006
Using quick-freeze/deep-etch electron microscopy of recombinant proteins adsorbed to mica, we show that NSF, the oligomeric ATPase involved in membrane fusion, is a hollow 10 × 16 nm cylinder whose conformation depends upon nucleotide binding. Depleted nucleotide, NSF converts "splayed" protease-sensitive reveals its subunit composition. NSF's synaptic substrate, ternary SNARE complex containing syntaxin, SNAP-25, and synaptobrevin, 4 14 rod with "tail" at one end, corresponding N-terminus...
Summary Initiation and maintenance of infection by mycobacteria in susceptible hosts are not well understood. A screen Mycobacterium marinum transposon mutant library led to isolation eight mutants that failed cause haemolysis, all which had insertions genes homologous a region between Rv3866 Rv3881c tuberculosis , encompasses RD1 ( Rv3871–Rv3879c ), known virulence gene cluster. The M. showed decreased vivo secrete ESAT‐6, like . Rv3866‐Rv3868 also accumulate intracellular suggesting...
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1-5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of in cohort Japanese individuals collected during initial waves pandemic, with 3,289 unaffected controls. We identified variant on chromosome 5 at 5q35 (rs60200309-A), close to dedicator cytokinesis 2 gene (DOCK2), which was associated patients less than 65 years age. This risk allele prevalent East Asian but rare...
Toxoplasma gondii is a member of the phylum Apicomplexa, diverse group intracellular parasites that share unique form gliding motility. Gliding substrate dependent and occurs without apparent changes in cell shape absence traditional locomotory organelles. Here, we demonstrate characterized by three distinct forms motility: circular gliding, upright twirling, helical rotation. Circular commences while crescent-shaped parasite lies on its right side, from where it moves counterclockwise...
KL-6 is a pulmonary epithelial mucin more prominently expressed on the surface membrane of alveolar type II cells when these are proliferating, stimulated, and/or injured. We hypothesized that high levels in lining fluid and plasma would reflect severity lung injury patients with acute (ALI). Epithelial was obtained at onset ( day 0) 1 respiratory distress syndrome (ARDS)/ALI by bronchoscopic microsampling procedure 35 patients. On 0, albumin concentrations were significantly higher than...
We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization Japan, by COVID-19 waves, from conventional strains Delta variant.We used secondary data a database and performed retrospective cohort study that included 3261 aged ≥ 18 years enrolled 78 hospitals participated Japan Task Force between February 2020 September 2021.Patients hospitalized during second (mean age, 53.2 [standard deviation {SD}, ± 18.9]) fifth...
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 disease 2019 (COVID-19) patients 75 healthy controls Japanese ancestry with host genetic data. COVID-19 showed a low fraction nonclassical monocytes (ncMono). report downregulated transitions classical to ncMono reduced CXCL10 expression...
Since beta-blocker therapy is known to be effective in patients with an injured heart, such as infarction, we designed the present study examine protective effects of infusion beta1-selective blocker esmolol on myocardial function peritonitis-induced septic rats using isolated working heart preparation.Randomized animal study.University research laboratory.Thirty-one treated cecal ligation and perforation evoke peritonitis.After perforation, were randomly allocated control group (normal...
Proinflammatory cytokines play an important role in ventilator-induced lung injury (VILI). High-mobility group box-1 (HMGB1) is a macrophage-derived proinflammatory cytokine that can cause injury.This study tested the hypothesis HMGB1 released intact lungs ventilated with large Vt. A second objective was to identify source of HMGB1. third examine effects blocking on subsequent development VILI.Bronchoalveolar lavage fluid (BALF) and tissues were obtained from rabbits mechanically for 4 h...
Strong photoluminescence with sub-band-gap photon energies has been observed in fine Si particles prepared by the gas-evaporation technique. After surface oxidation, show above-band-gap photoluminescence, band tail covering visible light region. The amount of increased apparent gap (0.3 eV) estimated from this blueshift can be explained a quantum-size effect expected to quantum dots diameter 50 Å.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCurrent-doubling reactions on titanium dioxide photoanodesNorma Hykaway, W. M. Sears, Hiroshi Morisaki, and S. Roy MorrisonCite this: J. Phys. Chem. 1986, 90, 25, 6663–6667Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/j100283a014https://doi.org/10.1021/j100283a014research-articleACS PublicationsRequest reuse permissionsArticle...
A TiO2–solar-cell hybrid structure has been used successfully as the anode electrode in photoelectrolysis of water. The TiO2 films have fabricated by chemical vapor deposition. Conversion efficiency solar energy about 0.1% attained preliminary experiment.
Background:Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied.
A noninvasive bronchoscopic microsampling (BMS) probe was developed to sample biochemical constituents of the epithelial lining fluid in small airways.Observational, controlled study.Intensive care unit academic medical center. PATIENTS AND PROCEDURE: BMS applied a control group seven patients who had hemoptysis or solitary peripheral nodules but no hypoxemia other signs acute inflammation and four with respiratory distress syndrome (ARDS), test whether can ascertain presence pulmonary...
We tested the hypothesis that type of fluid infused to chronically maintain intravascular volumes would modify both microvascular integrity and cellular structure in extrapulmonary organs hyperdynamic sepsis. After cecal ligation perforation, awake sheep were treated for 48 h with 10% pentastarch (n = 9), pentafraction (Du Pont Critical Care; n 8), or Ringer lactate 8) titrated a constant left atrial pressure. therapy, biopsy samples taken from ventricle gastrocnemius electron microscopy. At...
Loss of prolyl hydroxylase 2 (PHD2) activates the hypoxia-inducible factor-dependent hypoxic response, including anaerobic glycolysis, which causes large amounts lactate to be released from cells into circulation. We found that Phd2-null mouse embryonic fibroblasts (MEFs) produced more than wild-type MEFs, as expected, whereas systemic inactivation PHD2 in mice did not cause hyperlacticacidemia. This unexpected observation led us hypothesize response activated liver enhances Cori cycle, a...