A5044208614- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Proteoglycans and glycosaminoglycans research
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Tryptophan and brain disorders
- Glycosylation and Glycoproteins Research
- Receptor Mechanisms and Signaling
- Plant biochemistry and biosynthesis
- Caveolin-1 and cellular processes
- Essential Oils and Antimicrobial Activity
- Neurogenesis and neuroplasticity mechanisms
- Inhalation and Respiratory Drug Delivery
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Evolutionary Psychology and Human Behavior
- Lipid Membrane Structure and Behavior
- Functional Brain Connectivity Studies
- Optical Imaging and Spectroscopy Techniques
- Advanced Glycation End Products research
Kawasaki University of Medical Welfare
2017-2025
University of Toyama
2018-2024
Okayama University
2011-2019
Kawasaki College of Allied Health Professions
2015-2017
Saga University
2017
Kindai University
1980-2014
Kyoto Prefectural University of Medicine
2004-2008
Ono Pharmaceutical (Japan)
2006
Tokyo Women's Medical University
2006
Keio University
2006
This study was performed to examine the putative role of high mobility group box (HMGB) protein in pathogenesis acute lung injury (ALI). Observations were made (1) 21 patients who septic with ALI and 15 normal function (2) a mouse model 24 hours after intratracheal instillation lipopolysaccharide (LPS). The concentrations HMGB1 increased plasma epithelial lining fluid mice instilled LPS. LPS-induced mitigated by anti-HMGB1 antibody. Although this not detected control humans or mice,...
In mouse studies, the results of behavioural experiments are greatly affected by differences in experimental environment and handling methods. The Porsolt forced swim test tail suspension widely used to evaluate predictive models depression-like behaviour mice. It has not been clarified how these tests testing single or multiple mice simultaneously. Therefore, this study evaluated between two simultaneously separately. To investigate effect simultaneously, were performed three patterns: (1)...
Proinflammatory cytokines play an important role in ventilator-induced lung injury (VILI). High-mobility group box-1 (HMGB1) is a macrophage-derived proinflammatory cytokine that can cause injury.This study tested the hypothesis HMGB1 released intact lungs ventilated with large Vt. A second objective was to identify source of HMGB1. third examine effects blocking on subsequent development VILI.Bronchoalveolar lavage fluid (BALF) and tissues were obtained from rabbits mechanically for 4 h...
Abstract Mice are the most commonly used laboratory animals for studying diseases, behaviour, and pharmacology. Behavioural experiment battery aids in evaluating abnormal behaviour mice. During behavioural experiments, mice frequently experience human contact. However, effects of repeated handling on remains unclear. To minimise stress, methods moving using transparent tunnels or cups have been recommended but impractical tests. investigate these effects, we a test to assess differences...
Abstract Interest in the societal and psychological harm caused by widespread envy social comparison is increasing. Envy associated with anxiety depression, though mechanism which affects neuropsychiatric disorders, such as remains unclear. Clarifying neurobiological basis of envy’s effects on behaviour emotion regulation experimental mice essential for developing disease-prevention treatment strategies. As recognize other neighbouring cages, this study investigated whether they cages housed...
Abstract Spontaneously hyperlipidaemic (Apoe shl ) mice were discovered in 1999 as lacking apolipoprotein E (ApoE) owing to a mutation the Apoe gene. However, age-related behavioural changes commercially available have not yet been clarified. The abnormalities of ApoE-deficient mice, which are genetically modified artificially deficient ApoE, investigated detail, and it has reported that they can serve model Alzheimer’s disease (AD). To understand whether also murine AD, is necessary...
Extracellular adenosine 5'-triphosphate (ATP) is an endogenous signaling molecule involved in multiple biological phenomena, including inflammation. The effects of extracellular ATP the lung have not been fully clarified. This study examined 1) roles pathogenesis inflammation and 2) possibility involvement mechanical ventilation-induced injury.The intratracheal on permeability, edema or were assessed by measurements wet-to-dry weight ratio permeability index, immunohistochemistry expression...
Rose oil has traditionally been used to treat psychiatric disorders, but the scientific basis of this treatment remains poorly understood. The main odor component rose is 2-phenylethanol (2-PE), neuropsychological effects 2-PE have not investigated in detail. Thus, we aimed investigate on mouse behavior. We first whether attractive or repulsive mice. After inhalation, mice underwent a series behavioral experiments, such as elevated plus maze, open field, Y-maze, tail-suspension, and Porsolt...
Many neuropsychiatric disorders develop in early life. Although the mechanisms involved have not been elucidated, it is possible that functional abnormalities of parvalbumin-positive interneurons (PV neurons) are present. Several previous studies shown juvenile stress implicated development disorders. We aimed to clarify effects on behavior and central nervous system. investigated behavioral chronically-stressed mice during juvenilehood effect PV neurons WFA-positive perineuronal nets...
Prosocial behaviour, including helping benefits others. Recently, helping-like behaviour has been observed in rats, but whether it is oriented towards rescue, social contact with others, or other goals remains unclear. Therefore, we investigated could be mice similar to that rats. Because are animals widely used neuroscience, the discovery of would valuable clarifying psychological and biological mechanisms underlying pro-sociability. We constrained inside tubes. Subject were allowed move...
Specific regions of the cerebral cortex are highly plastic in an organism's lifetime. It is thought that perineuronal nets (PNNs) regulate plasticity, but labeling for Wisteria floribunda agglutinin (WFA), which widely used to detect PNNs, observed throughout cortex. The aggrecan molecule—a PNN component—may and may also be involved determining region-specific vulnerability stress. To clarify cortical plasticity vulnerability, we qualitatively analyzed aggrecan-positive glycosylated PNNs...
Abstract Acting without the expectation of compensation is called prosocial behaviour. Since behaviour requires high cognitive and social abilities, it has been thought to be only shown by primates. Although recently reported in rats, there are still questions regarding this finding. We demonstrated rescue-like mice a previous report. In study, we investigated motives underlying for constrained cage-mates among mice. prepared either tube containing ball yarn or an opaque assessed whether...
In the developing central nervous system (CNS), extracellular matrix (ECM) molecules have regulating roles such as in brain development, neural-circuit maturation, and synaptic-function control. However, excluding perineuronal net (PNN) area, distribution, constituent elements, expression level of granular ECM (diffuse ECM) present mature CNS remain unclear. Diffuse share components PNNs are likely functional. As cortical functions greatly region-dependent, we hypothesized that would differ...
Mice are social animals that change their behaviour primarily in response to visual, olfactory, and auditory information from conspecifics. Rearing conditions such as cage size colour important factors influencing mouse behaviour. In recent years, transparent plastic cages have become standard breeding cages. The advantage of using a is the experimenter can observe outside without touching cage. However, mice may recognise environment We speculated housed might neighbouring used only male...
α -Pinene, an organic terpene compound found in coniferous trees, is used as a safe food additive and contained many essential oils. Moreover, some studies have shown that -pinene suppresses neuronal activity. In this study, we investigated whether inhalation of dizocilpine (MK-801-) induced schizophrenia-like behavioural abnormalities mice. Mice inhaled 1 h before the first MK-801 injection. Thirty minutes after injection, open field, spontaneous locomotor activity, elevated plus maze,...
Abstract Introduction Empathic behavior is essential for social activities in animals. Therefore, lack of empathy a feature several neuropsychiatric disorders. However, the underlying mechanisms and which animals possess it remain unclear. In this study, we investigated whether mice show empathic behavior. Methods We tested empathy‐like behaviors toward conspecifics who were distressed. behavioral changes cage‐mate or stranger mice. Results When conspecific painful state, subject showed...
Vanillin is widely used in food and cosmetics, among other substances, for its sweet smell. However, the neuropsychological effects of vanillin inhalation have not been elucidated. In this study, we investigated effect on mouse behavior. First, whether aroma was attractive or repulsive mice. Thereafter, mice inhaled 20 min before each test a series behavioral tests (elevated plus maze, open field, Y-maze, tail suspension, cotton bud biting, Porsolt forced swim tests). these tests, showed...
Abstract Background Empathy refers to the ability recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their empathise. However, these observation systems, it remains unclear whether observer mouse truly recognises movements of, empathises with, demonstrator mouse. We examined changes behaviour of an when was anaesthetised, demonstrator’s activity increased, interval electrical stimulation...