A5061429529- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Anesthesia and Pain Management
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Pituitary Gland Disorders and Treatments
- EEG and Brain-Computer Interfaces
- Central Venous Catheters and Hemodialysis
- Nausea and vomiting management
- Thermal Regulation in Medicine
- Optical Imaging and Spectroscopy Techniques
- Adrenal and Paraganglionic Tumors
- Renal function and acid-base balance
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Thermoregulation and physiological responses
- Epilepsy research and treatment
- Climate Change and Health Impacts
- Nosocomial Infections in ICU
- Vascular Procedures and Complications
- Cardiac Arrest and Resuscitation
Hamamatsu University School of Medicine
2014-2024
Hamamatsu Medical Center
2024
Hamamatsu University
2004-2021
Hamamatsu University Hospital
2004-2020
National University of Malaysia
2006
Marymount University
1999-2003
Leeds General Infirmary
2000
NHS Lanarkshire
2000
Glasgow Royal Infirmary
2000
HCI International Medical Centre
1997-1999
Background Drug effect lags behind the blood concentration. The goal of this investigation was to determine time course plasma concentration and effects propofol demonstrated by electroencephalogram or pressure changes compare them between elderly young middle-aged patients. Methods A target-controlled infusion used rapidly attain maintain four sequentially increasing, randomly selected concentrations from 1 12 microg/ml in 41 patients aged 20-85 yr. target maintained for about 30 min....
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set clinical practice guidelines sepsis septic shock created jointly by the Society Intensive Care Medicine Association Acute Medicine, was first released in February 2017 published Journal JSICM, [2017; Volume 24 (supplement 2)] https://doi.org/10.3918/jsicm.24S0001 28, 1)] http://onlinelibrary.wiley.com/doi/10.1002/jja2.2017.28.issue-S1/issuetoc . This abridged...
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), a Japanese-specific set clinical practice guidelines sepsis septic shock created as revised from J-SSCG 2016 jointly by the Society Intensive Care Medicine Association Acute Medicine, was first released in September published February 2021. An English-language version these based on contents original Japanese-language version. purpose this guideline is to assist medical staff making...
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) has an extremely poor prognosis and there is currently no effective treatment for this condition. Direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) improves oxygenation, but it unclear whether AE-IPF PMX-DHP affects survival. This study elucidated the effectiveness safety AE-IPF.This included 31 patients 41 episodes AE-IPF. All received steroids. Of 31, 14 (20 episodes) were treated PMX-DHP. The laboratory...
Background and Purpose The Japanese Clinical Practice Guidelines for Management of Sepsis Septic Shock 2016 (J‐ SSCG 2016), a Japanese‐specific set clinical practice guidelines sepsis septic shock created jointly by the Society Intensive Care Medicine Association Acute Medicine, was first released in February 2017 Japanese. An English‐language version these based on contents original Japanese‐language version. Methods Members were selected organized into 19 committee members 52 working group...
The respiratory effects of sevoflurane were studied in seven patients and compared with values obtained another anesthetized halothane. Resting ventilation, resting Paco2, ventilatory response to CO2 measured awake at 1.1 1.4 MAC levels both anesthetic agents. We found that sevoflurane, tidal volume the slopes curves decreased Paco2 increased increasing depth anesthesia, as other inhaled anesthetics. A compensatory increase frequency was not enough prevent a decrease minute anesthesia. At...
Remimazolam is a novel ultrashort-acting benzodiazepine that has recently become available for general anesthesia. However, the incidence of postoperative nausea and vomiting (PONV) associated with remimazolam remains unknown. In this propensity score-matched, retrospective, observational study, we compared rates PONV between propofol.In retrospective score-matching was performed to minimize selection bias. Patients who received total intravenous anesthesia or propofol at Hamamatsu...
Background The auditory evoked potential (AEP) index, which is a single numerical parameter derived from the AEP in real time and describes underlying morphology of AEP, has been studied as monitor anesthetic depth. current study was designed to evaluate accuracy AEPindex for predicting depth sedation anesthesia during sevoflurane anesthesia. Methods In first phase study, end-tidal concentration ranging 0.5 0.9% assigned randomly administered each 50 patients. Bispectral Index (BIS) were...
We studied the effects of hypothermia and cardiopulmonary bypass (CPB) on four depth anaesthesia monitors; spectral edge frequency (SEF), median (MF), bispectral index (BIS) auditory evoked potential (AEPIndex) in 12 patients during uneventful cardiac anaesthesia. Each variable was recorded simultaneously at 10 periods All variables were not affected by transition to CPB. During hypothermia, values AEPIndex, MF SEF tightly distributed but BIS very overlapped with those before induction The...
Essentials•Thrombomodulin (TM)/thrombin activatable fibrinolysis inhibitor function was successfully evaluated using tissue-type plasminogen activator-induced plasma clot lysis time (tPA-PCLT).•Soluble TM (sTM) in normal appeared to effectively activate thrombin and prolong tPA-PCLT.•Supplementation of recombinant sTM further tPA-PCLT.•Recombinant administration disseminated intravascular coagulation patients prolonged tPA-PCLT; the effect which lasted at least 24...
レミマゾラムはイミダゾベンゾジアゼピン骨格を持ち,ジアゼピン環にエステル結合を含む側鎖を持つことが特徴で,代謝物が薬理活性を示さない.健康ボランティアを対象とした第I相試験では,単回投与時の消失相血中半減期は39~53分であった.0.2mg/kg単回投与で全被験者が意識消失した.64歳以下の非高齢者55症例,65歳以上の高齢者30症例を対象とした前期第II相試験では,麻酔維持での平均投与速度は非高齢者で1.02mg/kg/h,高齢者で0.72mg/kg/hで,血圧,脈拍の変動は軽微であった.レミマゾラムは,水溶性製剤であること,循環動態の安定性と特異的拮抗薬を持つ点でプロポフォールを凌駕する.レミマゾラムは全身麻酔時の催眠作用に優れた特性を備えており,有望な次世代の静脈麻酔薬である.
This study examined the sedative effect of, and hemodynamic response to dexmedetomidine administration in propofol-sedated swine. Sixteen swine were subjects. After anesthetic induction preparation, propofol infusion rate was adjusted maintain a bispectral index (BIS) value between 55 65 (i.e., baseline). With fixed at baseline rate, infused continuously of 0.2, 0.4, 0.7 μg·kg –1·h–1 for one hour each rate. The BIS parameters recorded step. Dexmedetomidine decreased value, mean arterial...