A5034426677- Epigenetics and DNA Methylation
- Metabolism and Genetic Disorders
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cholinesterase and Neurodegenerative Diseases
- Antibiotic Resistance in Bacteria
- Cancer-related gene regulation
- Pancreatic function and diabetes
- Monoclonal and Polyclonal Antibodies Research
- Lipoproteins and Cardiovascular Health
- Biochemical and Molecular Research
- Erythrocyte Function and Pathophysiology
- Genetics and Neurodevelopmental Disorders
- Molecular Biology Techniques and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Asthma and respiratory diseases
- Bacterial Identification and Susceptibility Testing
- Acute Myeloid Leukemia Research
- Mitochondrial Function and Pathology
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- Alkaline Phosphatase Research Studies
- Cardiac Imaging and Diagnostics
Hamamatsu University Hospital
2016-2025
Kobe University
1999-2025
Hamamatsu University School of Medicine
2015-2024
Aichi Medical University
1997-2024
Saitama University
2018-2024
Toyohashi University of Technology
2024
Japan Society for the Promotion of Science
2023
Bavarian Nordic (Denmark)
2023
Japan Tobacco (Japan)
2022-2023
Niigata University
2022-2023
We have isolated a chromosomal DNA segment of the human IL-4 gene based on homology with cDNA sequence and determined its complete nucleotide sequence. The gene, which occurs as single copy in haploid genome, is mapped chromosome 5. It composed four exons three introns approximately 10 kilobase pairs size. 5'-Flanking regions mouse genes share about 85% extending more than 500 base upstream "TATA" like Several patches sequences are found 5'-flanking region homologous to IL-2, IL-3, IL-5,...
In pancreatic cancer, the incidence and mortality curves coincide. One major reason for this high rate in ductal adenocarcinoma (PDAC) patients is dearth of effective diagnostic, prognostic, disease-monitoring biomarkers. Unfortunately, existing tumor markers, as well current imaging modalities, are not sufficiently sensitive and/or specific early-stage diagnosis. There is, therefore, an urgent need improved serum markers disease. Herein, we performed Orbitrap® mass spectrometry proteomic...
After documenting the presence of obstructive sleep apnea syndrome (OSAS) through polysomnography monitoring, we performed simultaneous ambulatory recordings electrocardiogram, oronasal airflow, and pulse oximetry on 12 OSAS patients with normal autonomic nervous function for a period 24 hours. The power spectrum heart rate variability was investigated before during treatments using dental appliances. Frequency domain analysis showed that very low frequency component (0.008–0.04 Hz)...
Background The aim of this study was to evaluate the cumulative incidence and predictive factors for collagen vascular disease (CVD) in patients initially diagnosed with idiopathic pulmonary fibrosis (IPF), examine features who then developed CVD. Methods This a retrospective review 111 consecutive IPF at our institution. None fulfilled any CVD criteria from American College Rheumatology (ACR) within 6 months or more after diagnosis IPF. Results Ten (9.0%) during follow-up period: four had...
To clarify the roles of Wnt pathway in medulloblastoma oncogenesis, immunohistochemical staining beta-catenin and Wnt-1 genomic analyses CTNNB1 (beta-catenin) AXIN1 (axin 1) were examined 23 sporadic cases. Accumulation tumor cells was immunohistochemically proven 5 cases; 2 cases showed positive immunoreactivity for another mutation either or AXIN1. exon 3, corresponding to GSK-3beta binding site its phosphorylation site. Disruption these proteins could result upregulation signaling...
We developed an automated enzymatic method for determination of the branched-chain amino acids (BCAAs; valine, isoleucine, leucine) and tyrosine in serum, applied it to clinical evaluation patients with various hepatic diseases. Analytically, test results were acceptably precise reproducible, correlated well obtained acid analyzer. Clinically, we found that a decrease BCAAs, increase tyrosine, BCAAs/tyrosine ratio serum paralleled severity parenchymal damage. conclude this BCAAs is simple...
DNA adducts are a major cause of mutation and mutation-related diseases, but the simultaneous identification multiple has been challenge for decade. An adductome approach using consecutive liquid chromatography double mass spectrometry after micrococcal nuclease treatment paved way to demonstrations numerous in single experiment is expected contribute comprehensive understanding overall environmental endogenous exposures possible mutagens individuals. In this report, we applied an gastric...
IL-17A, IL-17F, and IL-25 belong to the IL-17 family of cytokines, are well known play important roles in host defense against infection inflammatory diseases. IL-17C, also a member family, is highly expressed epithelium; however, function regulatory mechanism IL-17C airway epithelium remain poorly understood. In this study, we demonstrate that polyinosinic-polycytidylic acid (polyI:C), ligand Toll-like receptor 3, potent inducer mRNA protein expression primary normal human bronchial...
Abstract Purpose Tryptophan metabolites have immunomodulatory functions, suggesting possible roles in cancer immunity. Methods Plasma tryptophan were measured using liquid chromatography/mass spectrometry before immune checkpoint inhibitors (ICIs) patients with non-small cell lung (NSCLC). Results The 19 NSCLC had significantly lower levels of ( p = 0.002) and xanthurenic acid 0.032), a higher level 3-hydroxyanthranilic (3-HAA) 0.028) compared the 10 healthy volunteers. achieving objective...
Hypertriglyceridemia is associated with decreased HDL-cholesterol (HDL-C) and increased small dense LDL. In addition, LDL known to be susceptible oxidation.We measured particle size, using gradient gel electrophoresis, malondialdehyde-modified (MDA-LDL), an ELISA, investigated the association between triglyceride (TG) concentrations, MDA-LDL.TG concentrations correlated negatively predominant size (r = -0.650) HDL-C concentration -0.556). The relationship TG evaluated by measuring MDA-LDL,...
The effect of CMC-544, a calicheamicin-conjugated anti-CD22 monoclonal antibody, was analysed in relation to CD22 and P-glycoprotein (P-gp) B-cell chronic lymphocytic leukaemia (CLL) non-Hodgkin lymphoma (NHL) vitro. cell lines used were CD22-positive parental Daudi Raji, their P-gp positive sublines, Daudi/MDR Raji/MDR. Cells obtained from 19 patients with CLL or NHL also used. CMC-544 by viable count, morphology, annexin-V staining, cycle distribution. A dose-dependent, selective cytotoxic...
Abstract Muscle-invasive bladder cancer (MIBC), a highly heterogeneous disease, shows genomic instability and high mutation rate, making it difficult to treat. Recent studies revealed that stem cells (CSCs) play critical role in MIBC frequent recurrence morbidity. Previous research has shown Cyclooxygenases-2 (COX-2) is particularly expressed cells. In recent years, the development of oncolytic adenoviruses their use clinical trials have gained increased attention. this study, we composed...