A5080616879- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Biopolymer Synthesis and Applications
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Treatments and Studies
- Stochastic processes and financial applications
- Analytical Chemistry and Chromatography
- Pediatric Hepatobiliary Diseases and Treatments
- Epigenetics and DNA Methylation
- Metastasis and carcinoma case studies
- Superconducting Materials and Applications
- Esophageal and GI Pathology
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Physics of Superconductivity and Magnetism
- Hernia repair and management
- Viral-associated cancers and disorders
Osaka University
1998-2023
Ibaraki Prefectural Central Hospital
2008-2021
Japanese Red Cross Kanazawa Hospital
2020
Red Cross Hospital
2020
University of Tsukuba
2020
Jichi Medical University
2005-2018
Kanazawa Medical Center
2013-2015
National Hospital Organization
2011-2015
Kansai University
2013-2015
Tohoku University
2012
There have been few reports on (1) the nature and pathogenesis of small cystic lesions pancreas, (2) their incidence, age distribution, location, (3) significance as potential precursors intraductal papillary tumors, mucinous duct cell carcinomas. Materials: Epithelial growth in 300 consecutive autopsy cases seven carcinoma from among 2300 elderly cases, was evaluated by histopathological analysis. One hundred eighty-six were found 73 (24.3%). The incidence increased with age. Cystic equally...
The gastric hormone ghrelin and its receptor, growth secretagogue receptor (GHSR), are expressed in pancreas. Here, we report that is released from pancreatic islets to regulate glucose-induced insulin release. Plasma concentrations of ghrelin, as well insulin, were higher veins than arteries. GHSR antagonist immunoneutralization endogenous enhanced release perfused pancreas, whereas exogenous suppressed it. increased plasma levels gastrectomized normal rats a similar extent. Ghrelin...
Five cases of localized cystic dilatation a side branch the main pancreatic duct due to new entity ("ductectatic" mucinous cystadenoma and cystadenocarcinoma) are reported. The dilated was widely covered by epithelium indistinguishable from that (n = 4) or cystadenocarcinoma 1) pancreas. All lesions were located in uncinate process about 3 cm size. On computed tomographic scans sonograms, difficult distinguish simple cyst pancreas unless lobulated irregular margins demonstrated. Endoscopic...
Abstract Purpose: EBV-associated gastric carcinoma shows global CpG island methylation of the promoter region various cancer-related genes. To further clarify significance methylator phenotype (CIMP) status in carcinoma, we investigated profile and clinicopathologic features including overall survival four subgroups defined by EBV infection CIMP status: EBV-negative/CIMP-high (H), EBV-intermediate (I), EBV-negative (N) carcinoma. Experimental Design: Methylation-specific PCR was applied to...
Eight autopsy cases of pancreatic cancer (duct cell adenocarcinoma) with T1 and T2 primary tumors were studied histologically to examine the exact extent lymphatic local spread. Six them had microscopic metastasis in grossly negative lymph nodes near tumor. In addition, four a few metastatic para-aortic region. metastases, infiltration within vessels, nerves, and/or connective tissues was almost same as that node metastasis. Major vascular involvement found cases. There no case which...
A cooperative inhibitory effect of GM3, together with CD9, on haptotactic cell motility was demonstrated by a few lines study as described below. (i) Haptotactic colorectal carcinoma SW480, SW620, and HRT18, which express CD9 at high level, is inhibited exogenous but not GM1. (ii) Motility gastric cancer line MKN74, expresses low affected GM3. Its became susceptible to GM1, when the level MKN74 cells converted transfection cDNA. Findings i ii suggest that tumor cooperatively coexpression...
Abstract Activating mutations of BRAF have been frequently observed in microsatellite unstable (MSI + ) colorectal carcinomas (CRCs), which and KRAS are mutually exclusive. Previously, we reported that hypermethylation hMLH1 might play an important role the tumorigenesis right‐sided sporadic CRCs with MSI showing less frequency / TP53 alteration. Therefore, assumed be highly associated methylation status rather than status. In this study, their relationship were examined 140 resected...
Periostin is a unique extracellular matrix protein, deposition of which enhanced by mechanical stress and the tissue repair process. Its significance in normal neoplastic colon has not been fully clarified yet. Using immunohistochemistry immunoelectron microscopy with highly specific monoclonal antibody, periostin was observed close proximity to pericryptal fibroblasts colonic crypts. The pattern decreased adenoma adenocarcinoma, preceding decrease number fibroblasts. immunoreactivity...
Abstract Aqueous solubilities of benzene and alkylbenzenes, toluene, ethylbenzene, propyl- isopropylbenzene, (o-, m-, p-) xylene, (1,2,3-, 1,2,4-, 1,3,5-) trimethylbenzene, have been measured. An apparatus is described which provides a convenient means obtaining aqueous solutions saturated with solute vapor. The method involves introducing vapor, in equilibrium liquid solute, into water circulating it closed system. This has three principal advantages: (1) solubility can be attained within 3...
Selective endoscopic resection may cure early colorectal cancer (T1), but the management is controversial. There concern about small risk of lymph node metastasis, which will not be treated by alone. The authors sought predictive markers metastasis to assist patient management.The retrospectively analyzed consecutive cases T1 stage resected using or bowel surgery over period 1979 2000. was logistic regression model for selected univariate analysis: type initial treatment, depth submucosal...
The authors precisely examined the topography of duodenum, pancreas, bile duct, and supplying vessels from perspective performing duodenum-preserving resection pancreatic head.Little has been reported regarding detailed surgical anatomy that is crucial in this procedure.The local pancreas head using materials 40 autopsy cases.Arcade formation between anterior superior pancreaticoduodenal (ASPD) artery inferior (AIPD) was found all cases. After departing gastroduodenal artery, ASPD ran toward...
Abstract To clarify the significance of p73 in Epstein‐Barr virus (EBV)‐associated gastric carcinoma (GC), immunohistochemical expression and CpG‐island methylation were evaluated cancer tissues adjacent nonneoplastic GC with without EBV infection. Loss by immunohistochemistry was specific to EBV‐associated (11/13) compared EBV‐negative (3/38), which independent abnormal p53 expression. With methylation‐specific polymerase chain reaction (MSP), aberrant exon 1 similarly (12/13), also rare...
Abstract Background: The aim of this study was to identify a new plasma biomarker for use in early detection colorectal cancer. Methods: Using the combination hollow fiber membrane (HFM)-based low-molecular weight protein enrichment and two-dimensional image converted analysis liquid chromatography mass spectrometry (2DICAL), we compared proteome 22 cancer patients with those 21 healthy controls. An identified candidate then validated two larger cohorts [validation-1 (n = 210) validation-2...
The development of a new plasma biomarker for early detection would be necessary to improve the overall outcome colorectal cancer. Here we report identification and validation ninth component complement (C9) as novel cancer by cutting‐edge proteomic technologies. Plasma proteins were enzymatically digested into large array peptides, relative quantity total 94 803 peptide peaks was compared between 31 patients 59 age/sex‐matched healthy controls using 2D image‐converted analysis liquid...
Choledochal cyst is a rare congenital condition with high risk of malignant change if untreated. The malignancy after surgical excision choledochal not known.Forty-eight patients cysts managed over 21-year period were reviewed, to determine the excision. Thirty-nine 48 had no carcinoma at first admission; their mean(s.d.) age was 20(18) years. Thirty-seven 39 underwent and cholecystectomy followed by hepaticoenterostomy.Cyst incomplete in 28 37 because dilated portions biliary ducts remained...
Colorectal carcinoma (CRC) remains the major cause of cancer death in humans. Although chromosomal structural anomaly is presumed to play an important role carcinogenesis CRC, copy number alterations (CNA) and loss heterozygosity (LOH) have not yet been analyzed extensively at high resolution CRC. Here we aim identify recurrent CNA LOH human CRC with use single nucleotide polymorphism-typing microarrays, reveal their relevance clinical outcome. Surgically resected specimens paired normal...