A5105462834- Pediatric Hepatobiliary Diseases and Treatments
- Asthma and respiratory diseases
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Inhalation and Respiratory Drug Delivery
- Organ Transplantation Techniques and Outcomes
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Intestinal Malrotation and Obstruction Disorders
- Neuropeptides and Animal Physiology
- Clinical Nutrition and Gastroenterology
- Neonatal Respiratory Health Research
- Transplantation: Methods and Outcomes
- Tracheal and airway disorders
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Congenital Diaphragmatic Hernia Studies
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Dysphagia Assessment and Management
- Cardiac Ischemia and Reperfusion
- Airway Management and Intubation Techniques
- Phosphodiesterase function and regulation
- Cardiovascular Function and Risk Factors
Tohoku University
2014-2023
Suntory Foundation for Life Sciences
2020-2023
Tohoku University Hospital
2013-2023
Johns Hopkins University
2014-2021
Johns Hopkins Medicine
2014-2021
East Asia School of Theology
2021
Suntory (Japan)
2020
Miyagi Children's Hospital
2006-2019
National Cerebral and Cardiovascular Center
1987-2017
Fukuoka University Hospital
2017
Some studies have shown that metformin activates AMP-activated protein kinase (AMPK) and has a potent cardioprotective effect against ischemia/reperfusion injury. Because AMPK also is activated in animal models of heart failure, we investigated whether decreases cardiomyocyte apoptosis attenuates the progression failure dogs.Treatment with (10 micromol/L) protected cultured cardiomyocytes from cell death during exposure to H2O2 (50 via activation, as by MTT assay, terminal deoxynucleotidyl...
Pneumonia is a major cause of death in the elderly. To investigate role silent aspiration community-acquired pneumonia, we examined occurrence during sleep 14 elderly patients with acute episode pneumonia and 10 age-matched control subjects by new technique using indium111 chloride. Scanning thorax demonstrated that 71% aspirated, whereas was observed only 10% subjects. The percentage positive scans significantly higher than (p < 0.02). results may indicate an important development
Abstract To clarify the alterations of tau, amyloid β protein (Aβ) 1–40 and Aβ1–42(43) in cerebrospinal fluid (CSF) that accompany normal aging progression Alzheimer's disease (AD), CSF samples 93 AD patients, 32 longitudinal subjects among these 33 patients with non‐AD dementia, 56 other neurological diseases, 54 control from three independent institutes were analyzed by sensitive enzyme‐linked immunosorbent assays. Although tau levels increased aging, a significant elevation correlation...
We have previously reported that the prolonged transient acidosis during early reperfusion mediates cardioprotective effects in canine hearts. Recently, postconditioning has been shown to be one of novel strategies mediate cardioprotection. tested contribution cardioprotection postconditioning. Open-chest anesthetized dogs subjected 90-min occlusion left anterior descending coronary artery and 6-h were divided into four groups: 1) control group; no intervention after (n = 6); 2) (Postcon)...
How does smooth muscle tone affect the properties of airways during breathing maneuvers? We have studied dynamic relationships airway pressure and cross-sectional area in excised dog lobes isolated tracheal segments simulated maneuvers. When contracted by carbachol, developed complex hysteretic behavior, becoming less compliant small tidal breaths rapid deflations, grossly large For a given sequence maneuvers patterns hysteresis varied with timing. Analogous behavior was seen length-cycling...
Inhibition of cGMP-specific phosphodiesterase 5 (PDE5) ameliorates pathological cardiac remodeling and has been gaining attention as a potential therapy for heart failure. Despite promising results in males, the efficacy PDE5 inhibitor sildenafil female pathologies not determined might be affected by estrogen levels, given hormone's involvement cGMP synthesis. Here, we that heart-protective effect mice depends on presence via mechanism involves myocyte eNOS-dependent synthesis cGMP-dependent...
Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis treatment, it was considered necessary to formulate evidence-based clinical practice guidelines reflecting the most progress, guide of neonatologists, pediatric endocrinologists, general pediatricians, surgeons. These cover range aspects, including features congenital hyperinsulinism, diagnostic criteria tools for diagnosis, first- second-line medical details surgical future perspectives. were...
Biliary atresia (BA) is among the commonest indications for liver transplantation (LT) in children. We examined whether serum matrix metalloproteinase-7 (MMP-7) useful diagnosis of BA Japanese infants, and MMP-7 concentrations before after Kasai portoenterostomy (KP) predicted LT within a year.Subjects under 6 months old at eight pediatric centers Japan were enrolled retrospectively, including patients with cholestasis normal controls (NC) without disease. Patients divided into groups...
There are discrepancies regarding the clinical impact of age at Kasai portoenterostomy (KP) on surgical outcomes. Hence, we re-assessed significance KP. We analyzed 224 patients with type III (atresia bile duct porta hepatis) biliary atresia Tohoku University Hospital. classified into two groups: KP ≤60 days (group TE) and >60 TL). Group TE was subdivided three groups (TE1, TE2, TE3) according to time surgery. Subsequently, 2,643 in Japanese Biliary Atresia Registry were similarly....
Pneumonia is the most common cause of death from nosocomial infection in elderly. The increased incidence pneumonia and high mortality are consequences a number age-related factors, including coexisting illnesses, therapeutic interventions, aging process itself.1 has been estimated to occur about one third patients with stroke.2 important factor contributing risk stroke suggested be dysphagia aspiration.1 Angiotensin-converting enzyme (ACE) inhibitors have shown improve silent aspiration3...
Huntington's disease (HD) is a polyglutamine (polyQ) caused by aberrant expansion of the polyQ tract in Huntingtin (HTT). While motor impairment mediated polyQ-expanded HTT has been intensively studied, molecular mechanisms for nonmotor symptoms HD, such as psychiatric manifestations, remain elusive. Here we have demonstrated that forms ternary protein complex with scaffolding DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4) to regulate PDE4 activity. We observed pathological...
Cancer chemotherapy is associated with a variety of side effects/adverse events. It very important that patients adhere to the planned regimen, which necessitates minimum effects and these be kept under control. We have investigated patients' concerns symptoms during aim seek solutions will improve quality life chemotherapy.Forty-nine malignant diseases on parenteral antineoplastic agents were sequentially enrolled in this study. These completed questionnaire consisting 42 items related...