A5101399581- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Amyotrophic Lateral Sclerosis Research
- Botulinum Toxin and Related Neurological Disorders
- Autophagy in Disease and Therapy
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Neurogenetic and Muscular Disorders Research
- Lysosomal Storage Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Glioma Diagnosis and Treatment
- RNA regulation and disease
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Carcinogens and Genotoxicity Assessment
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
Hirosaki University
2016-2025
Tokyo Women's Medical University
2018-2022
Transnational Press London
2021-2022
Shibuya (Japan)
2022
Hirosaki University Hospital
2021
Hirosaki National Hospital
2021
Kyushu University
2015-2017
Niigata University
1995-2011
Augusta University
2011
Ehime University
2011
Degeneration of the cardiac sympathetic nerve occurs in both Parkinson's disease (PD) and dementia with Lewy bodies begins early progression PD, accounting for reduced uptake meta-iodobenzylguanidine even stages body (LBD). We previously demonstrated that degeneration distal axons precedes loss their mother neurons paravertebral ganglia, suggesting dominant PD. Because α-synuclein is one key molecules pathogenesis this disease, we further investigated how aggregates are involved...
α-Synuclein is one of the major components intracellular fibrillary aggregates in brains a subset neurodegenerative disorders, including Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and Hallervorden-Spatz which are referred to as α-synucleinopathies. We have shown previously (Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., Iwatsubo, T. (2002) <i>Nat. Cell Biol.</i> 4, 160–164) that α-synuclein deposited...
Abstract To clarify the alterations of tau, amyloid β protein (Aβ) 1–40 and Aβ1–42(43) in cerebrospinal fluid (CSF) that accompany normal aging progression Alzheimer's disease (AD), CSF samples 93 AD patients, 32 longitudinal subjects among these 33 patients with non‐AD dementia, 56 other neurological diseases, 54 control from three independent institutes were analyzed by sensitive enzyme‐linked immunosorbent assays. Although tau levels increased aging, a significant elevation correlation...
The gastrointestinal motor stimulating activity of erythromycin (EM) was studied in conscious dogs. It found that a 20-min intravenous infusion EM lactobionate at dose 50-100 micrograms (potency) X kg-1 h-1 induced group strong contractions the stomach and duodenum, migrated along small intestine to terminal ileum. EM-induced were quite similar naturally occurring interdigestive migrating (IMC) tract frequency, contractile force, duration contractions, velocity, accompanying peaks plasma...
<b><i>Article abstract</i></b> Heart tissues of patients with PD or incidental Lewy body (LB) disease (ILBD) were examined by light and electron microscopy. LBs α-synuclein–positive neurites identified in the hearts from 9 11 7 ILBD. present both tyrosine hydroxylase-positive -negative nerve processes, which are nerves extrinsic sympathetic intrinsic origin, respectively. These findings provide histologic evidence that postganglionic neurons heart involved process.
Decreased cardiac uptake of meta ‐iodobenzylguanidine (MIBG) on [ 123 I] MIBG myocardial scintigraphy has been reported in the early stages Parkinson’s disease (PD), which suggests involvement sympathetic nerve process PD. For confirmation, we immunohistochemically examined tissue, ganglia and medulla oblongata 20 patients with incidental Lewy body (ILBD), is thought to be a presymptomatic stage PD, 10 control subjects, using antibodies against tyrosine hydroxylase (TH) neurofilament (NF)....
USING two-site enzyme immunoassays (EIAs), we measured the levels of neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic (BDNF) and neurotrophin-3 (NT-3) simultaneously in three brain regions (motor cortex, dentate gyrus entorhinal cortex) patients with Alzheimer's disease (AD) control individuals. Significant differences between neurotrophin these two groups were found different depending on neurotrophin. The NGF level AD was higher, whereas BDNF cortex NT-3 motor lower...
Sporadic amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder affecting adults. We studied the neuropathology and clinical correlations in 102 autopsy cases of ALS. The age at onset disease was significantly higher for bulbar‐onset form (30 cases) than limb‐onset (72 cases). Dementia confirmed 7 cases. These were divided into 4 pathological subgroups: typical ALS (59 cases), lower‐motor‐predominant (23 with temporal lesions (18 pallido‐nigro‐luysian degeneration (2 In lower...
Many mutagenic heterocyclic amines (HAs) have been isolated from cooked foods and pyrolysates of amino acids proteins, the carcinogenicity 10 these HAs in rodents 1 monkeys has reported. Quantification carcinogenic various kinds indicated that level 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was highest (0.56-69.2 ng/g), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) second (0.64-6.44 those other were 0.03-2.50 ng/g. Heterocyclic found urine samples healthy volunteers...
Many neurodegenerative diseases share a common pathological feature: the deposition of amyloid-like fibrils composed misfolded proteins. Emerging evidence suggests that these proteins may spread from cell-to-cell and encourage propagation neurodegeneration in prion-like manner. Here, we demonstrated α-synuclein (αSYN), principal culprit for Lewy pathology Parkinson's disease (PD), was present endosomal compartments detectably secreted into extracellular milieu. Unlike prion protein, αSYN...