A5101422423- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Viral Infections and Immunology Research
- Inflammatory Myopathies and Dermatomyositis
- Muscle Physiology and Disorders
- Receptor Mechanisms and Signaling
- Calpain Protease Function and Regulation
- Genetic Neurodegenerative Diseases
- Adrenal Hormones and Disorders
- Nerve injury and regeneration
- Neurological disorders and treatments
- Pituitary Gland Disorders and Treatments
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Hematological disorders and diagnostics
- Restless Legs Syndrome Research
- Genetic Syndromes and Imprinting
- Kruppel-like factors research
- Geophysical and Geoelectrical Methods
- Suicide and Self-Harm Studies
- Nausea and vomiting management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cholinesterase and Neurodegenerative Diseases
- HIV-related health complications and treatments
Nihon University
2004-2023
Kobe City Medical Center General Hospital
2002-2011
Eiju General Hospital
2004
Kobe University
1988-2000
Shinko Hospital
1998-1999
The binding of the diphenyl-substituted piperazine derivative, [3H]GBR-12935, a selective dopamine uptake inhibitor, to post-mortem human putamen was studied. Inhibition curves by inhibitors suggested existence two populations [3H]GBR-12935 sites: one is potently inhibited mazindol and/or nomifensine, and second site benztropine- GBR 12909-sensitive. In putamen, labeled both these distinct sites. displaced enriched in mouse rat striatum, but not cultured neuroblastoma cell N1E-115....
Individuals with rheumatoid arthritis (RA) are at a heightened risk of sudden cardiac death, an outcome increased in those prolongation the corrected electrocardiographic QT interval (QTc). We compared QTc between patients RA and demographically matched controls studied change after treatment interleukin 6 inhibitor tocilizumab (TCZ).Standard 12-lead electrocardiograms were obtained was measured baseline 24 weeks TCZ treatment, then non-RA who frequency-matched on age sex. Indicators...
To prospectively investigate the effect of tocilizumab (TCZ) on levels N-terminal pro-brain natriuretic peptide (NT-proBNP), as a predictor congestive heart failure (CHF) in patients with active rheumatoid arthritis (RA).Seventy RA (median age 59 years, 86% female) free cardiovascular disease were treated TCZ and followed for 24 weeks. The NT-proBNP measured at baseline week 24. Thirty healthy controls included comparison normal those patients.The level was significantly higher than 42.5...
Some studies have reported that a suicide attempt has cathartic effect. We studied change of suicidal ideation just before and after to test whether effect exists and, if does exist, identify factors may affect it. Subjects consisted 88 attempters (29 males, 59 females, mean age=35.5 years) who attended the emergency medical center Kobe City General Hospital, Kobe, Japan. Strength was evaluated by 11 steps from 0 10, where indicates no 10 strongest ideation. were also interviewed about any...
Abstract We investigated changes in signal transduction via calcineurin (CaN) the striatum of rats behaviorally sensitized to methamphetamine (Meth). The were injected with Meth (4 mg/kg, s.c.) five times a week for 3 weeks and then given challenge dose (2 s.c.). Seven days after test, we determined levels CaN Aα Aβ by Western blotting. further immunoquantified DARPP‐32 (dopamine‐ cAMP‐regulated phosphoprotein, mw 32,000) phosphothreonine‐DARPP‐32, which can be dephosphorylated at threonine...
<h3>Background</h3> Polymyositis (PM) and dermatomyositis (DM) are autoimmune systemic diseases characterized by muscle weakness inflammatory cell infiltration into skeletal muscle. Myocardial involvement is a common cause of death in PM/DM. It has been reported that myocardial observed 9% to 72% PM/DM [1], but it still unclear. Electrocardiogram (ECG) echocardiography the most often used tests evaluate cardiac abnormalities, early detection difficult. Cardiac magnetic resonance (CMR)...
The binding of the diphenyl-substituted piperazine derivative, [3H]GBR-12935, a selective dopamine uptake inhibitor, to post-mortem human putamen was studied. Inhibition curves by inhibitors suggested existence two populations [3H]GBR-12935 sites: one is potently inhibited mazindol and/or nomifensine, and second site benztropine-and/or GBR 12909-sensitive. In putamen, labeled both these distinct sites. displaced enriched in mouse rat striatum, but not cultured neuroblastoma cell N1E-115....
The specificity of cytoarchitectural abnormalities in limbic structures patients with schizophrenia and their contributions towards the etiology remain unknown. We have recently reported an increased breakdown nonerythroid α-spectrin (fodrin), a major component neuronal cytoskeletal proteins, schizophrenic left superior temporal cortices [Kitamura et al., 1998: Biol Psychiatry 43:254–262], suggesting that polymorphisms gene might contribute to vulnerability schizophrenia. screened for...