A5021450167- Viral Infections and Immunology Research
- Rheumatoid Arthritis Research and Therapies
- Salivary Gland Disorders and Functions
- Systemic Sclerosis and Related Diseases
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Systemic Lupus Erythematosus Research
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Infrared Thermography in Medicine
- Muscle Physiology and Disorders
- Eosinophilic Disorders and Syndromes
- Salivary Gland Tumors Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Heart Rate Variability and Autonomic Control
- Connective Tissue Growth Factor Research
- Diabetes and associated disorders
- Vasculitis and related conditions
- Inflammatory Myopathies and Dermatomyositis
- Sarcoidosis and Beryllium Toxicity Research
- Immune Cell Function and Interaction
- Peripheral Neuropathies and Disorders
Nihon University
2015-2021
Mie Chuo Medical Center
2013-2015
Nihon University Itabashi Hospital
2015
Funabashi Central Hospital
2014
Individuals with rheumatoid arthritis (RA) are at a heightened risk of sudden cardiac death, an outcome increased in those prolongation the corrected electrocardiographic QT interval (QTc). We compared QTc between patients RA and demographically matched controls studied change after treatment interleukin 6 inhibitor tocilizumab (TCZ).Standard 12-lead electrocardiograms were obtained was measured baseline 24 weeks TCZ treatment, then non-RA who frequency-matched on age sex. Indicators...
Abstract Aim To evaluate left ventricular (LV) dysfunction in patients with rheumatoid arthritis (RA) and to determine the impact of biological treatment on LV function these using global circumferential strain (GCS), longitudinal (GLS) radial (GRS) values assessed by feature tracking cardiac magnetic resonance (FT‐CMR) imaging. Methods Eighty RA 20 controls without cardiovascular disease underwent non‐contrast CMR Patients received conventional synthetic disease‐modifying antirheumatic...
The risk of clinically manifested major cardiovascular (CV) events in primary Sjögren syndrome (pSS) remains unclear. This study aimed to assess myocardial fibrosis pSS and investigate the associated disease characteristics by cardiac magnetic resonance imaging (cMRI).We performed a cross-sectional patients with without symptoms. Labial gland biopsy was documented 44 (85%). Patients CV factors underwent contrast-enhanced cMRI. Late gadolinium enhancement (LGE) used fibrosis. Myocardial edema...
To evaluate subclinical left ventricular (LV) regional dysfunction in patients with primary Sjögren's syndrome (pSS) using feature tracking cardiac magnetic resonance (FT-CMR) imaging and to identify pSS characteristics independently associated LV dysfunction.Fifty 20 controls without cardiovascular disease underwent non-contrast CMR imaging. Labial gland biopsy was performed 42 (84%). Disease activity assessed the European League Against Rheumatism index (ESSDAI). global longitudinal strain...
A 26-year-old woman presented with abdominal pain, diarrhoea, vomiting, fever, and progressive paralysis in the lower limbs. She had a history of bronchial asthma experienced sinusitis, peripheral neuropathy, polyarthritis, leukocytosis prominent eosinophilia. The patient was diagnosed eosinophilic granulomatosis polyangiitis (EGPA). Abdominal pain considered to be an ischaemic enteritis associated EGPA. administered 1,000 mg/day methylprednisolone for 3 days intravenous immunoglobulin (400...
<h3>Background</h3> Individuals with rheumatoid arthritis (RA) are at a 2-fold increased risk of sudden death compared age- and gender-matched controls without RA. Although mechanisms underlying the yet unclear, evidence indicates effects systemic inflammation on ventricular repolarization. Accordingly, corrected QT (QTc) interval prolongation is more frequent in patients RA than those A previous pilot study reported that tocilizumab (TCZ) normalizes QTc by dampening inflammation....
関節リウマチ（rheumatoid arthritis：RA）に対してetanercept（ETN）治療中の74歳女性．低疾患活動性で推移していたが，投与開始6年後，皮膚・肺サルコイドーシスを発症した．さらに，心臓 MRIでは心筋炎を示唆する所見を得た．ETNによるサルコイドーシス発症の可能性を考え，投与を中止したところ所見の改善を得た．TNF阻害薬投与中のサルコイドーシス発症はparadoxical reactionとして注目されており，通常の発症より明らかに頻度が高く注意を要する．
症例は56歳，女性．20歳頃月経時に発熱と腹痛が生じ，その後月経周期に一致して症状を繰り返すため近医で精査するも異常所見を認めなかった．症状は月経終了後無治療で自然軽快していた．父親にも同様の症状が出現していたことから，遺伝性自己炎症性疾患を疑い遺伝子検査を施行したところ，MEFV遺伝子変異を認めたため家族性地中海熱（Familial Mediterranean fever：FMF）と診断した．コルヒチン投与後症状は消失し，現在までアミロイドーシスの発症も認めていない．
<h3>Background</h3> Rheumatoid arthritis (RA) is a multi-organ inflammatory disorder associated with high cardiovascular morbidity and mortality. Importantly, cardiac involvements are typically clinically silent, only manifesting as myocardial abnormalities after an extended subclinical phase. Myocardial may arise from number of distinct processes, including inflammation (myocarditis), and/or fibrosis, any which be active in RA. <h3>Objectives</h3> We sought to assess involvement using...
<h3>Background</h3> Rheumatoid arthritis (RA) is associated with an increased risk of congestive heart failure, possibly via shared mechanisms inflammation. This study was undertaken to test the hypothesis that powerful anti-inflammatory effect anti-interleukin 6 (tocilizumab: TCZ) therapy might lead a reduction in left ventricular (LV) dysfunction patients (pts) RA. To our knowledge, there are no published reports on use cardiac magnetic resonance imaging (CMR) for investigating LV...
症例は44歳，女性．2012年11月初旬から発熱，咳嗽が増悪し，11月下旬に意識障害を契機に当院搬送となった．初診時Ⅰ型呼吸不全，ショックを呈しており，両側中下肺野の湿性ラ音，右不全片麻痺，頭頚部や四肢に多発する紅斑と紫斑が認められた．肝腎機能障害，炎症反応上昇，凝固線溶系の顕著な異常，脳梗塞，両肺下葉の浸潤影を認め，重症肺炎や劇症型抗リン脂質抗体症候群（CAPS）に伴う多臓器障害，播種性血管内凝固を疑い加療を開始．シプロフロキサシン，ドリペネム，トロンボモジュリン，アンチトロンビンIIIの投与に加え，メチルプレドニゾロンパルス療法を行った．抗菌薬投与により炎症反応の改善を認め，入院時の抗リン脂質抗体価が正常であったため，CAPSは否定的であると考えプレドニゾロン投与を中止した．しかし，第7病日の検査にて抗カルジオリピンIgM抗体価が上昇しており，その後の再検査で抗カルジオリピンβ2GPI抗体価の一過性の上昇を認めた．さらに，第8病日に凝固線溶系の改善に相応しない血小板減少，肺胞出血が出現．CAPSの診断のもと，メチルプレドニゾロンパルス療法を行った後，プレドニゾロン投与を継続．...
<h3>Background</h3> Polymyositis (PM) and dermatomyositis (DM) are inflammatory diseases; up to 70% affected patients (pts) show cardiac involvement, which may be fatal. However, the diagnosis, based on electrocardiogram, laboratory, imaging investigations, is difficult because of nonspecific clinical presentation lack standardized criteria. Cardiac magnetic resonance (CMR) currently best technique for diagnosing fibrosis inflammation. <h3>Objectives</h3> To evaluate involvement in PM/DM pts...
<h3>Background</h3> Individuals with rheumatoid arthritis (RA) have a twofold higher risk of developing sudden death than age and gender matched controls without RA. The underlying mechanisms not yet been clarified. <h3>Objectives</h3> aim this study was to prospectively investigate the association myocardial involvement assessed by cardiac magnetic resonance imaging (CMR) QTc interval in RA symptoms. <h3>Methods</h3> patients control subjects no history and/or clinical findings systemic...
<h3>Background</h3> The TCZ treatment for RA is known that there a discrepancy within DAS remission and SDAI rate cause by the weight of gravity acute phase reactants. Especially strongly inhibits CRP which produced liver through IL-6. Therefore even if we meet to remission; come across cases occasionally who have not been sufficiently suppressed clinically. Considering this, examined difference background factors in addition remission. <h3>Objectives</h3> To compare patients with showed...