A5100853740- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Suicide and Self-Harm Studies
- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Ion channel regulation and function
- Genetics and Neurodevelopmental Disorders
- Nicotinic Acetylcholine Receptors Study
- Genetic Associations and Epidemiology
- Optical Imaging and Spectroscopy Techniques
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Obsessive-Compulsive Spectrum Disorders
- Neurological disorders and treatments
- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Alzheimer's disease research and treatments
Kindai University
2013-2022
Kobe University
2000-2015
Kobe Gakuin University
2010
University of Maryland, Baltimore
1991-1994
University of Maryland, College Park
1994
Quantitative evaluation of antimuscarinic effects antihistamines (H1- and H2-receptor antagonists) was carried out using a receptor-binding assay. The -inhibition constants (Ki values) twenty seven H1-receptor antagonists, one related antidepressant three antagonists at H1-receptors muscarinic receptors in the bovine cerebral cortex were determined. All examined showed very low affinity for receptors. On other hand, some (mequitazine, cyproheptazine, clemastine, diphenylpyraline,...
Previous neuroimaging studies have revealed frontal and temporal functional abnormalities in patients with major depressive disorder (MDD) a history of suicidal behavior. However, it is unknown whether multi-channel near-infrared spectroscopy (NIRS) signal changes among individuals MDD are associated suicide attempts diathesis for behavior (impulsivity, hopelessness, aggression). Therefore, we aimed to explore frontotemporal hemodynamic responses depressed using 52-channel NIRS. We recruited...
Abstract Many postsynaptic density proteins carrying density‐95/discs large/zone occludens‐1 (PDZ) domain(s) interact with glutamate receptors to control receptor dynamics and synaptic plasticity. Here we examined the expression of PDZ proteins, synapse‐associated protein (SAP) 97, (PSD)‐95, chapsyn‐110, GRIP1 SAP102, in post‐mortem brains schizophrenic patients subjects, evaluated their contribution pathology. Among these SAP97 exhibited most marked change: levels were decreased less than...
Abstract Short telomere length (TL) occurs in individuals under psychological stress, and with various psychiatric diseases. Recent studies have also reported mitochondrial DNA copy number (mtDNAcn) alterations several neuropsychiatric conditions. However, no study has examined whether aberrant TL or mtDNAcn occur completed suicide, one of the most serious outcomes mental illnesses. post-mortem samples from 528 suicide completers without severe physical illness (508 peripheral bloods; 20...
Cytogenomic mutations and chromosomal abnormality are implicated in the neuropathology of several brain diseases. Cell heterogeneity tissues makes their detection validation difficult, however. In present study, we analyzed gene dosage alterations DNA schizophrenia patients compared those with copy number variations (CNVs) identified as well Asian lymphocyte attempted to obtain hints at pathological contribution cytogenomic instability schizophrenia. Brain was extracted from postmortem...
For patients with a major depressive episode, early differential diagnosis of bipolar disorder and subsequent appropriate treatment are critical. This study, conducted in clinical settings Japan, examined episode to investigate the prevalence predictors disorders.A total 448 were interviewed using Mini-International Neuropsychiatric Interview determine presence mood episodes psychiatric comorbidities. The was based on collected information according DSM-IV-TR.Of 114 (25.4%) diagnosed...
Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on world scale. Twin, family, adoption studies suggested heritability for suicide, but genetics lags behind due to difficulty in obtaining samples from individuals who died by especially non-European populations. In this study, we carried out genome-wide association combining two independent datasets totaling 746 suicides 14,049 non-suicide controls the...
Background: Given a lack of markers, diagnoses bipolar disorder (BD) and major depressive (MDD) rely on clinical assessment symptoms. However, the mood states BD symptoms MDD are often difficult to distinguish, which leads misdiagnoses, in turn inadequate treatment. Previous studies have shown that hemodynamic responses left frontopolar cortex measured by near-infrared spectroscopy (NIRS) differ between MDD; these associated with altered mitochondrial metabolism; DNA copy number (mtDNAcn),...
Men have a higher rate of completed suicide than women, which suggests that sex chromosome abnormalities may be related to the pathophysiology suicide. Recent studies found an aberrant loss Y (LOY) in various diseases; however, no study has investigated whether there is association between LOY and The purpose this was determine occurs men who Our consisted 286 male Japanese subjects comprised 140 completers without severe physical illness (130 post-mortem samples peripheral blood 10 brains)...