A5069264604- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Amyotrophic Lateral Sclerosis Research
- Neuroscience and Neuropharmacology Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Down syndrome and intellectual disability research
- Nuclear Receptors and Signaling
- Neurological Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Mitochondrial Function and Pathology
- Memory and Neural Mechanisms
- Spectroscopy and Chemometric Analyses
- S100 Proteins and Annexins
- Rocket and propulsion systems research
- Energetic Materials and Combustion
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Cerebrovascular and genetic disorders
University of Manchester
2015-2024
Salford Royal Hospital
2015-2024
University of Salford
2006-2023
Salford Royal NHS Foundation Trust
2012-2022
Goethe University Frankfurt
2021
Greater Manchester STEM Centre
2002-2018
University College London
2014-2018
University of California, San Francisco
2018
University of Reading
2018
Washington University in St. Louis
2018
Biologically formed nanoparticles of the strongly magnetic mineral, magnetite, were first detected in human brain over 20 y ago [Kirschvink JL, Kobayashi-Kirschvink A, Woodford BJ (1992) Proc Natl Acad Sci USA 89(16):7683-7687]. Magnetite can have potentially large impacts on due to its unique combination redox activity, surface charge, and behavior. We used analyses electron microscopy identify abundant presence magnetite that are consistent with high-temperature formation, suggesting,...
Parkinson's disease (PD) and other related disorders are characterized by the accumulation of fibrillar aggregates alpha-synuclein protein (alpha-syn) inside brain cells. It is likely that formation alpha-syn plays a seminal role in pathogenesis at least some these diseases, because two different mutations gene encoding have been found inherited forms PD. alpha-Syn mainly expressed neuronal cells generally considered to exist as cytoplasmic protein. Here, we report unexpected identification...
Missense mutations in the alpha-synuclein gene cause familial Parkinson's disease (PD), and is a major component of Lewy bodies (LBs) sporadic PD, dementia with LBs (DLB), LB variant Alzheimer's (AD). To determine whether AD (FAD) patients known presenilin (n = 65) or amyloid precursor protein 9) genes, studies were conducted antibodies to alpha-, beta-, gamma-synuclein. detected alpha- but not beta- gamma-synuclein 22% FAD brains, alpha-synuclein-positive most numerous amygdala where some...
Abstract Computer visualization techniques were used to map and quantitatively reconstruct the entire locus coeruleus, including nucleus subcoeruleus, compare topographic patterns of cell loss in postmortem brains from patients with Parkinson's disease, Alzheimer's Down syndrome. There was comparable all three diseases (approximately 60%) compared aged normal subjects, there a significant subcoeruleus cells specifically disease (63%). positive correlation between magnitude coeruleus duration...
α-Synuclein is one of the major components intracellular fibrillary aggregates in brains a subset neurodegenerative disorders, including Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and Hallervorden-Spatz which are referred to as α-synucleinopathies. We have shown previously (Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., Iwatsubo, T. (2002) <i>Nat. Cell Biol.</i> 4, 160–164) that α-synuclein deposited...
Objective: We aimed to determine the extent which patients with progressive language impairment conform 2011 primary aphasia (PPA) classification and examine clinicopathologic correlations within PPA variants. Methods: Sixty-two consecutive pathologically confirmed dementia who presented clinically were identified. Patients insufficient clinical information excluded. classifications applied anonymized data taken from patients' initial assessment by raters blinded pathologic diagnosis....
Intracellular filamentous tau pathology is the defining feature of tauopathies, which form a subset neurodegenerative diseases. We have analyzed pathological in Alzheimer's disease, and frontotemporal lobar degeneration associated with tauopathy to include cases Pick bodies, corticobasal degeneration, progressive supranuclear palsy, ones due intronic mutations MAPT. found that C-terminal band pattern species distinct for each disease. Immunoblot analysis trypsin-resistant indicated different...
Abstract The chronological relationship regarding deposition of amyloid β protein (Aβ) species, Aβ40 and Aβ42(43), was investigated in 16 brains from Down syndrome patients aged 31 to 64 years. frontal cortex probed with two end‐specific monoclonals that recognize or Aβ42(43). All senile plaques detected an authentic monoclonal were also Aβ42(43) positive, but only a varying proportion positive. In young (≤ 50 years old) there many Aβ42(43)‐positive, Aβ40‐negative diffuse plaques, few...
In thirteen cases of senile dementia the Alzheimer type severe loss nerve cells from locus caeruleus was frequently seen together with reductions in nucleolar volume and cytoplasmic RNA surviving cells, averaging 14 21 per cent respectively. These histological findings were matched two by biochemical measurements noradrenaline all brain regions examined, ranging 10 temporal cortex to 53 hypothalamus. By contrast, neither nor altered substantia nigra, dopamine content significantly most...
The receptor for fibronectin is a member of the integrin superfamily cell surface adhesion receptors, many which recognize sequence RGD in their ligands. We have developed sensitive enzyme-linked and radioreceptor assays to examine ligand specificity receptor. bound only various Arg-Gly-Asp (RGD)-containing proteins tested. smallest amount detectable assay was about 10 ng. Mn2+ enhanced binding 3-10-fold as compared Ca2+ Mg2+. Scatchard analysis saturation plot from gave dissociation...
Abstract: Indices of presynaptic serotonergic nerve endings were assayed in neocortical biopsy samples from patients with histologically verified Alzheimer's disease. The concentrations 5‐hydroxytryptamine (serotonin) and 5‐hydroxyindoleacetic acid, serotonin uptake, K + ‐stimulated release endogenous all found to be reduced below control values. Changes occurred both the frontal temporal lobes, but they most severe (at least a 55% reduction) lobe. This is indicative substantial denervation....