A5090672688- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology of Language and Bilingualism
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Memory and Neural Mechanisms
- Cerebrovascular and genetic disorders
- Neurological disorders and treatments
- Cholinesterase and Neurodegenerative Diseases
- Prion Diseases and Protein Misfolding
- Neurogenetic and Muscular Disorders Research
- Mitochondrial Function and Pathology
- Medical Imaging Techniques and Applications
- S100 Proteins and Annexins
- Neurological Disorders and Treatments
- Language Development and Disorders
- Bioinformatics and Genomic Networks
- Neurological and metabolic disorders
- Genetics and Neurodevelopmental Disorders
- Neurological Disease Mechanisms and Treatments
- Genomics and Rare Diseases
- Reading and Literacy Development
- RNA regulation and disease
University of Manchester
2014-2024
Salford Royal NHS Foundation Trust
2015-2024
Salford Royal Hospital
2013-2024
University of Salford
2002-2024
Istituto Universitario di Studi Superiori di Pavia
2022
University of Duisburg-Essen
2021
Manchester Academic Health Science Centre
2007-2018
Health Sciences Centre
2013-2016
Institute of Mental Health
2016
Greater Manchester STEM Centre
2001-2013
Presents case reports of a 67‐yr‐old man and 2 women (aged 60 66 yrs) with primary cerebral atrophy in whom progressive breakdown language visual perception are attributed to loss semantic information. This form dementia is distinct from that Alzheimer′s disease assumed represent circumscribed emphasis pathology temporal rather than frontal regions the brain.
To test predictions that frontotemporal dementia and semantic give rise to distinct patterns of behavioural change.An informant based semistructured interview, covering the domains basic social emotions, personal behaviour, sensory eating oral repetitive behaviours, rituals, compulsions, was administered carers 41 patients with apathetic (FTD-A) disinhibited (FTD-D) forms dementia.Consistent prediction, emotional changes differentiated FTD from dementia. Whereas lack response pervasive in...
A significant proportion of patients with presenile dementia due to primary cerebral atrophy do not have Alzheimer9s disease. One form non-Alzheimer may be designated as frontal lobe type (DFT), on the basis a characteristic neuropsychological picture suggestive disorder, confirmed by findings single photon emission tomography. The case histories seven exemplify disorder: presentation social misconduct and personality change, unconcern disinhibition, in presence physical well-being few...
A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition syndrome in a variety research settings.
The identification of a hexanucleotide repeat expansion in the C9ORF72 gene as cause chromosome 9-linked frontotemporal dementia and motor neuron disease offers opportunity for greater understanding relationship between these disorders other clinical forms lobar degeneration.In this study, we screened cohort 398 patients with dementia, progressive non-fluent aphasia, semantic or mixture syndromes mutations gene.Motor was present 55 (14%).We identified 32 mutations, representing 8% cohort.The...
Four patients are described, in whom a profound and rapidly progressive dementia occurred association with clinical features of motor neuron disease. The pattern indicated impaired frontal lobe function, confirmed by reduced tracer uptake the lobes on single photon emission computed tomography (SPECT). Pathological examination brains two revealed frontal-lobe atrophy, mild gliosis spongiform change. spinal cord changes were consistent picture pathological findings resembled those type...
Semantic dementia is a focal clinical syndrome, resulting from degeneration of the temporal lobes and characterized by progressive loss conceptual knowledge about world. Because highly circumscribed nature disorder it natural model for improving understanding how semantic information cerebrally represented. There currently lack consensus. One view proposes existence modality specific meaning systems, in which visual verbal are stored separately. An opposing assumes that represented unitary,...
Multiple neurotransmitter deficits found in recent autopsy studies of patients with Alzheimer's disease may militate against the success "simple cholinergic replacement" as treatment. To study acetylcholine synthesis, we measured incorporation radiolabeled glucose into transmitter temporal-cortex specimens obtained at diagnostic craniotomy 17 young disease. Synthesis was significantly correlated cognitive impairment. These results are consistent view that deficit presynaptic system is a...
We have investigated the extent and pattern of immunostaining for ubiquitin protein (UBQ) in 60 patients with frontotemporal lobar degeneration (FTLD) ubiquitin-positive, tau-negative inclusions (FTLD-U), 37 whom were ascertained Manchester UK 23 Newcastle-Upon-Tyne, UK. There three distinct histological patterns according to form distribution UBQ pathology. Histological type 1 was present 19 (32%) characterised by presence a moderate number, or numerous, immunoreactive neurites...
Accuracy of clinical diagnosis dementia is increasingly important for therapeutic and scientific investigations. In this study, we examine diagnostic accuracy in a consecutive series 228 patients referred to specialist early-onset clinic, whose brains were subsequently examined at post-mortem. Diagnosis was based on structured history, neurological examination neuropsychological assessment, with emphasis qualitative as well quantitative aspects performance. Neuroimaging provided support but...
Objective: We aimed to determine the extent which patients with progressive language impairment conform 2011 primary aphasia (PPA) classification and examine clinicopathologic correlations within PPA variants. Methods: Sixty-two consecutive pathologically confirmed dementia who presented clinically were identified. Patients insufficient clinical information excluded. classifications applied anonymized data taken from patients' initial assessment by raters blinded pathologic diagnosis....