A5002754020- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurobiology of Language and Bilingualism
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Spatial Neglect and Hemispheric Dysfunction
- S100 Proteins and Annexins
- Health, Environment, Cognitive Aging
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Associations and Epidemiology
- Language Development and Disorders
- EEG and Brain-Computer Interfaces
- Reading and Literacy Development
- Frailty in Older Adults
- Bioinformatics and Genomic Networks
- Advanced Neuroimaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Neurological Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Cognitive Functions and Memory
- Epigenetics and DNA Methylation
- Action Observation and Synchronization
- Aging and Gerontology Research
Northwestern University
2016-2025
Alzheimer’s Disease Neuroimaging Initiative
2011-2024
Northwestern Medicine
2024
San Francisco VA Medical Center
2024
University of California, San Francisco
2024
Liechtenstein Institute
2023
Hudson Institute
2023
John Wiley & Sons (United States)
2023
Harvard University
1986-2022
University of Antwerp
2022
The National Institute on Aging and the Alzheimer's Association charged a workgroup with task of revising 1984 criteria for disease (AD) dementia. sought to ensure that revised would be flexible enough used by both general healthcare providers without access neuropsychological testing, advanced imaging, cerebrospinal fluid measures, specialized investigators involved in research or clinical trial studies who have these tools available. We present all‐cause dementia AD retained framework...
Based on the recent literature and collective experience, an international consortium developed revised guidelines for diagnosis of behavioural variant frontotemporal dementia. The validation process retrospectively reviewed clinical records compared sensitivity proposed earlier criteria in a multi-site sample patients with pathologically verified lobar degeneration. According to criteria, 'possible' dementia requires three six clinically discriminating features (disinhibition,...
This article provides a classification of primary progressive aphasia (PPA) and its 3 main variants to improve the uniformity case reporting reliability research results. Criteria for PPA--nonfluent/agrammatic, semantic, logopenic--were developed by an international group PPA investigators who convened on occasions operationalize earlier published clinical descriptions subtypes. Patients are first diagnosed with then divided into based specific speech language features characteristic each...
Cognition is 1 of 4 domains measured by the NIH Toolbox for Assessment Neurological and Behavioral Function (NIH-TB), complements modules testing motor function, sensation, emotion. On basis expert panels, cognition subdomains identified as most important health, success in school work, independence daily functioning were Executive Function, Episodic Memory, Language, Processing Speed, Working Attention. Seven measures designed to tap constructs within these subdomains. The instruments...
A Clinical Task Force, composed of clinical leaders from Alzheimer's Disease Centers (ADC), was convened by the National Institute on Aging to develop a uniform set assessment procedures characterize individuals with mild Alzheimer disease and cognitive impairment in comparison nondemented aging. The resulting Uniform Data Set (UDS) defines common observations be collected longitudinally ADC participants accordance standard methods. UDS implemented at all ADCs September 1, 2005. obtained are...
In this chapter, we discuss two measures designed to assess executive function (EF) as part of the NIH Toolbox Cognition Battery (CB) and report pediatric data from validation study. EF refers goal-directed cognitive control thought, action, emotion. Two were adapted for standardized computer administration: Dimensional Change Card Sort (a measure flexibility) a flanker task inhibitory in context selective visual attention). Results reveal excellent developmental sensitivity across...
Large numbers of neurofibrillary tangles (NFTs) and amyloid plaques are diagnostic markers for Alzheimer disease (AD), but lesser these lesions also seen in nondemented elderly individuals. Much the existing literature suggests that NFTs AD have a closer correlation with cognitive function than do plaques. Whether similar relationship exists normal aging mild impairment (MCI), condition frequently reflects preclinical stage AD, remains unknown.To determine distribution patterns beta-amyloid...
Null mutations in the progranulin gene ( PGRN ) were recently reported to cause tau-negative frontotemporal dementia linked chromosome 17. We assessed genetic contribution of an extended population patients with lobar degeneration (FTLD) N =378). Mutations identified 10% total FTLD and 23% a positive family history. This mutation frequency dropped 5% when analysis was restricted unbiased subpopulation =167) derived from referred Alzheimer's Disease Research Centers (ADRC). Among ADRC...
Abstract Objective To identify predictors of Alzheimer's disease (AD) versus frontotemporal lobar degeneration pathology in primary progressive aphasia (PPA), and determine whether the AD is atypically distributed to fit aphasic phenotype. Methods Neuropsychological neuropathological analyses 23 consecutive PPA autopsies. All had qualitative determination neurofibrillary tangle (NFT) density. Additional quantitation was done four PPA/AD cases with typical amnestic dementia Alzheimer type....
The neuropsychological battery of the Uniform Data Set (UDSNB) was implemented in 2005 by National Institute on Aging (NIA) Alzheimer Disease Centers program to measure cognitive performance dementia and mild impairment due Disease. This paper describes a revision, UDSNB 3.0.
The frontal aslant tract is a direct pathway connecting Broca's region with the anterior cingulate and pre-supplementary motor area. This left lateralized in right-handed subjects, suggesting possible role language. However, there are no previous studies that have reported an involvement of this language disorders. In study we used diffusion tractography to define anatomy relation verbal fluency grammar impairment primary progressive aphasia. Thirty-five patients aphasia 29 control subjects...
• Tasks based on visuomotor scanning and tactile exploration were used to quantitate neglect behavior in patients with unilateral brain damage normal control subjects. The results confirm previous observations that<i>contralateral</i>neglect is markedly more severe following right-hemisphere injury that it independent of the modality sensory input or motor output. In addition, also showed multimodal for targets hemisphere<i>ipsilateral</i>to lesion. emergence both contralateral ipsilateral...
Abstract This study describes psychometric properties of the NIH Toolbox Cognition Battery (NIHTB-CB) Composite Scores in an adult sample. The NIHTB-CB was designed for use epidemiologic studies and clinical trials ages 3 to 85. A total 268 self-described healthy adults were recruited at four university-based sites, using stratified sampling guidelines target demographic variability age (20–85 years), gender, education, ethnicity. contains seven computer-based instruments assessing five...
Abstract The cholinergic denervation in Alzheimer's disease (AD) provides the rationale for treatments with anticholinesterases. presence of this lesion is solidly established advanced AD. Whether it also exists early remains unsettled. This question was addressed thioflavin‐S histofluorescence to identify neurofibrillary tangles (NFT) and two tau antibodies (AT8, Alz‐50) pre‐tangle cytopathology nucleus basalis, source cortical innervation. Methods concurrent visualization tauopathy choline...
The characteristics of early and mild disease in primary progressive aphasia are poorly understood. This report is based on 25 patients with quotients >85%, 13 whom were within 2 years symptom onset. Word-finding spelling deficits the most frequent initial signs. Diagnostic imaging was frequently negative consultations seldom reached a correct diagnosis. Functionality preserved, so that fit current criteria for single-domain cognitive impairment. One goal to determine whether recently...
Fifty-eight autopsies of patients with primary progressive aphasia are reported.Twenty-three these were previously described (Mesulam et al., 2008) but had their neuropathological diagnoses updated to fit current criteria.Thirty-five the cases new.Their clinical classification was guided as closely possible by 2011 consensus guidelines (Gorno-Tempini 2011).Tissue included Alzheimer's disease in 45% and frontotemporal lobar degeneration (FTLD) others, an approximately equal split between TAR...
• In 14 patients, we encountered a behavioral syndrome that begins in early life and is characterized by emotional interpersonal difficulties, shyness, visuospatial disturbances, inadequate paralinguistic communicative abilities. All patients had at least average intellectual capacity, but each demonstrated some academic failure, particularly arithmetic. Examination revealed neurologic neuropsychological signs consistent with right-hemisphere dysfunction. Most of the avoided eye contact...