A5013836410- Dementia and Cognitive Impairment Research
- Music Therapy and Health
- Neuroscience and Music Perception
- Geriatric Care and Nursing Homes
- Health disparities and outcomes
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- Intensive Care Unit Cognitive Disorders
- Neurological Disease Mechanisms and Treatments
- Neurology and Historical Studies
- Aging and Gerontology Research
- Amyotrophic Lateral Sclerosis Research
- Art Therapy and Mental Health
- Parkinson's Disease Mechanisms and Treatments
- Mental Health and Patient Involvement
- Cardiac Health and Mental Health
- Mental Health and Psychiatry
- Diverse Music Education Insights
- Hearing Loss and Rehabilitation
- Health and Well-being Studies
- Ethics in Clinical Research
- Memory and Neural Mechanisms
- History of Medicine Studies
- Musicology and Musical Analysis
University of California, San Francisco
2016-2025
Institute on Aging
2016-2025
University of Pennsylvania
2007-2022
Unity Health System
2022
University of California System
2021
University of Helsinki
2017
Alzheimer’s Disease Neuroimaging Initiative
2010
University Memory and Aging Center
2002-2010
University of California San Francisco Medical Center
2003-2006
Hospital of the University of Pennsylvania
2005
Based on the recent literature and collective experience, an international consortium developed revised guidelines for diagnosis of behavioural variant frontotemporal dementia. The validation process retrospectively reviewed clinical records compared sensitivity proposed earlier criteria in a multi-site sample patients with pathologically verified lobar degeneration. According to criteria, 'possible' dementia requires three six clinically discriminating features (disinhibition,...
Abstract We performed a comprehensive cognitive, neuroimaging, and genetic study of 31 patients with primary progressive aphasia (PPA), decline in language functions that remains isolated for at least 2 years. Detailed speech evaluation was used to identify three different clinical variants: nonfluent (NFPA; n = 11), semantic dementia (SD; 10), third variant termed logopenic (LPA; 10). Voxel‐based morphometry (VBM) on MRIs showed that, when all PPA were analyzed together, the left...
To assess the ability of a brief neuropsychological bedside screening battery to discriminate between Alzheimer disease, frontotemporal dementia, and semantic dementia.Subjects were 21 patients with 14 30 disease comparable in terms Mini Mental Status Examination score, age, education. Frontotemporal dementia diagnoses made clinically using consensus criteria Neary et al. 1 Subjects administered assessing episodic memory, working executive function, naming, spatial ability, abstract...
Abstract Objective Frontotemporal lobar degeneration (FTLD) is characterized by impairments in social, behavioral, and/or language function, but postmortem studies indicate that multiple neuropathological entities lead to FTLD. This study assessed whether specific clinical features predict the underlying pathology. Methods A clinicopathological correlation was performed on 90 consecutive patients with a pathological diagnosis of frontotemporal dementia and compared an additional 24 cases...
<h3>Background</h3> Until recently, frontotemporal lobar degeneration (FTLD) was considered a rare neurodegenerative disorder that difficult to diagnose. The publication of consensus criteria for FTLD, however, prompted systematic studies. categorize FTLD into 3 subgroups: dementia, semantic and progressive nonfluent aphasia. <h3>Objective</h3> To compare demographic characteristics patients in the subgroups. <h3>Design</h3> We compared diagnostic breakdown, age at onset, sex, Mini-Mental...
To evaluate the clinical and pathological features of a subgroup patients with Alzheimer disease (AD) who exhibited early disproportionately severe impairments on tests frontal lobe functioning. We hypothesized that these would exhibit greater degree either neurofibrillary tangle (NFT) or senile plaque pathology in lobes than typical AD.We examined neuropsychological profiles NFT accumulation frontal, entorhinal, temporal, parietal cortices 3 AD disproportionate during stages dementia...
Purpose of the Study: During aging, musical activities can help maintain physical and mental health cognitive abilities, but their rehabilitative use has not been systematically explored in persons with dementia (PWDs). Our aim was to determine efficacy a novel music intervention based on coaching caregivers PWDs either singing or listening regularly as part everyday care. Design Methods: Eighty-nine PWD–caregiver dyads were randomized 10-week group (n = 30), 29), usual care control 30). The...
Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including dementia (FTD), FTD ALS (FTD/ALS), progressive nonfluent aphasia, semantic (SD), corticobasal degeneration, and supranuclear palsy were analyzed to determine the degree of heritability these disorders. FTD/ALS was most SD least heritable subtype. FTLD syndromes appear have different etiologies recurrence risks.
<b>Background: </b> Frontotemporal lobar degeneration (FTLD) is a common cause of non-Alzheimer dementia, but its natural history and the factors related to mortality in affected patients are not well understood. <b>Methods: This retrospective, longitudinal study compared survival FTLD (n = 177) with Alzheimer disease (AD; n 395). Hazards analysis investigated contribution various demographic, neuropsychiatric, neuropsychological variables associated neurologic neuropathologic findings....
To better define the anatomic distinctions between Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), we retrospectively applied voxel-based morphometry to earliest magnetic resonance imaging scans of autopsy-proven AD (N = 11), FTLD 18), controls 40). Compared with controls, patients showed gray matter reductions in posterior temporoparietal occipital cortex; atrophy medial prefrontal temporal cortex, insula, hippocampus, amygdala; both disorders dorsolateral orbital...
<b>Objective: </b> To investigate the clinical features of autopsy-proven corticobasal degeneration (CBD). <b>Methods: We evaluated symptoms, signs, and neuropsychological deficits longitudinally in 15 patients with CBD related these observations directly to neuroanatomic distribution disease. <b>Results: At presentation, a specific pattern cognitive impairment was evident, whereas an extrapyramidal motor abnormality present less than half patients. Follow-up examination revealed persistent...
Frontotemporal lobar degeneration (FTLD) often overlaps clinically with corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP), both of which have prominent eye movement abnormalities. To investigate the ability oculomotor performance to differentiate between FTLD, Alzheimer's disease, CBS PSP, saccades smooth pursuit were measured in three FTLD subtypes, including 24 individuals frontotemporal dementia (FTD), 19 semantic (SD) six non-fluent aphasia (PA), as compared 28 15 CBS,...
To provide guidance on standards for reporting studies of diagnostic test accuracy dementia disorders.
We examined the influence of a broad spectrum life experiences on longitudinal cognitive trajectories in demographically diverse sample older adults.
Abstract Objectives To test effects of the Community Voices choir intervention on health, well-being, and health care costs racial/ethnically diverse older adults. Method Twelve Administration-on-Aging-supported senior centers were cluster randomized into two groups: group started immediately a wait-list control began 6 months later. The program was designed for community-dwelling adults aged 60 years older. multimodal comprises activities that engage participants cognitively, physically,...
Abstract In 2016, the UC Davis Latino Aging Research Resource Center and Alzheimer's Disease brought together experts from across country to consolidate current knowledge identify future directions in aging diversity research. This report disseminates research priorities that emerged this conference, building on an earlier Gerontological Society of America preconference. We review key racial/ethnic differences cognitive dementia gaps field. advocate for a systems‐level framework whereby...
To determine if more widespread cognitive deficits are present in a narrowly defined group of patients with the amnestic form mild impairment (MCI).From larger sample clinically diagnosed as meeting criteria Petersen et al. for MCI, we selected 22 subjects who had Clinical Dementia Rating scores zero on all domains besides memory and orientation. These MCI presumably isolated impairments were compared to 35 age-matched normal controls 33 very Alzheimer's disease (AD) battery...
Abstract Objective Subgroups of mild cognitive impairment (MCI) have been proposed, but few studies investigated the nonamnestic, single‐domain subgroup MCI. The goal study was to compare clinical and neuroimaging characteristics two MCI subgroups: amnestic dysexecutive Methods We compared cognitive, functional, behavioral, brain imaging patients with (n = 26), 32), age‐ education‐matched control subjects 36) using analysis variance χ 2 tests. used voxel‐based morphometry examine group...
Information on anticipated survival time after dementia diagnosis among racially/ethnically diverse patients is needed to plan for care and evaluate disparities.Dementia-free health members aged ≥64 years were followed (1/1/2000-12/31/2013) subsequent (n = 23,032 Asian American; n 18,778 African 21,000 Latino; 4543 American Indian/Alaska Native; 206,490 white). Kaplan-Meier curves estimated by race/ethnicity. We contrasted mortality patterns people with versus without using Cox proportional...
ABSTRACT Background: Enhancing quality of life (QOL) older adults is an international area focus. Identifying factors and experiences that contribute to QOL helps promote optimal levels functioning. This study examines the relationship between perceived benefits associated with choral singing among community-dwelling adults. Methods: One hundred seventeen who sing in community choirs Jyväskylä, Finland, completed self-report measures (WHOQOL-Bref), depressive symptoms, a questionnaire about...
To examine the lived experience of older adults living alone with cognitive impairment to better understand their needs and concerns. Based on our previous work suggesting that often a sense precarity, we were interested in exploring this construct diagnosis impairment. The notion precarity points uncertainty deriving from coping cumulative pressures while trying preserve independence.This is qualitative study 12 aged 65 Six participants had Alzheimer's disease; 6 mild Participants'...
Background: Little is known about subjective cognitive decline (SCD) in lesbian, gay, bisexual, and transgender (LGBT) older adults. Objectives: To examine SCD its association with dementia risk factors, other physical psychosocial health factors LGBT Methods: A cross-sectional study of was conducted adults, aged 50 ( n = 210). categorized based on endorsement memory problems one domain. Hierarchical logistic regression examined the associations between demographic SCD. Results: Nearly 25%...