A5059298173- Head and Neck Cancer Studies
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Global Cancer Incidence and Screening
- Lymphoma Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Voice and Speech Disorders
- Sperm and Testicular Function
- Colorectal Cancer Screening and Detection
- Neurobiology of Language and Bilingualism
- Reproductive Biology and Fertility
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Prenatal Screening and Diagnostics
- Nonmelanoma Skin Cancer Studies
- Endometrial and Cervical Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Cutaneous Melanoma Detection and Management
- Cancer Treatment and Pharmacology
- Alzheimer's disease research and treatments
- Chromosomal and Genetic Variations
- Cancer Immunotherapy and Biomarkers
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Glioma Diagnosis and Treatment
Northwestern University
2016-2025
University of Chicago
1993-2025
Google (United States)
1993-2022
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2010-2021
Moffitt Cancer Center
2019
Johns Hopkins University
2019
General Department of Preventive Medicine
2008-2018
Alzheimer’s Disease Neuroimaging Initiative
2006-2018
Northwestern Medicine
2018
Midwestern University
2014-2017
<h3>Background</h3> Most previous estimates of the prevalence chronic fatigue syndrome (CFS) have derived largely from treated populations, and been biased by differential access to health care treatment linked with sex, ethnic identification, socioeconomic status. <h3>Objective</h3> To assess point CFS in an ethnically diverse random community sample. <h3>Design Participants</h3> A sample 28,673 adults Chicago, Ill, was screened telephone, those CFS-like symptoms were medically evaluated....
Conventional transarterial chemoembolization (cTACE) is used to treat patients with hepatocellular carcinoma (HCC). Radioembolization a minimally invasive procedure that involves implantation of radioactive micron-sized particles loaded yttrium-90 (Y90) inside the blood vessels supply tumor. We performed randomized, phase 2 study compare effects cTACE and Y90 radioembolization in HCC.
Abstract Objective To identify predictors of Alzheimer's disease (AD) versus frontotemporal lobar degeneration pathology in primary progressive aphasia (PPA), and determine whether the AD is atypically distributed to fit aphasic phenotype. Methods Neuropsychological neuropathological analyses 23 consecutive PPA autopsies. All had qualitative determination neurofibrillary tangle (NFT) density. Additional quantitation was done four PPA/AD cases with typical amnestic dementia Alzheimer type....
The goals were to determine the prevalence of community-acquired methicillin-resistant Staphylococcus aureus colonization in patients with atopic dermatitis and whether suppression S growth sodium hypochlorite (bleach) baths intranasal mupirocin treatment improves eczema severity.A randomized, investigator-blinded, placebo-controlled study was conducted 31 patients, 6 months 17 years age, moderate severe clinical signs secondary bacterial infections. All received orally administered...
Purpose For women with breast cancer, the role of completion axillary lymph node dissection (ALND) after identification nodal metastases by sentinel biopsy (SLNB) has been questioned. Our objectives were to assess national evaluation practice patterns and examine differences in recurrence survival for SLNB alone versus ALND. Patients Methods From National Cancer Data Base (1998 2005), clinically node-negative cancer who underwent had identified. Practice outcomes examined patients ALND...
Diurnal fluctuations of motor and nonmotor symptoms a high prevalence sleep-wake disturbances in Parkinson disease (PD) suggest role the circadian system modulation these symptoms. However, surprisingly little is known regarding function PD whether dysfunction involved development PD.To determine relationship between timing amplitude 24-hour melatonin rhythm, marker endogenous rhythmicity, with self-reported sleep quality, severity daytime sleepiness, metrics.A cross-sectional study from...
Eleven of 69 prospectively enrolled primary progressive aphasics were selected for this study because peak atrophy sites located predominantly or exclusively within the anterior left temporal lobe. Cortical volumes in these areas reduced to less than half control values, whereas average volume elsewhere hemisphere deviated from values by only 8%. Failure name objects emerged as most consistent and severe deficit. Naming errors attributed pure retrieval failure if object could not be named...
As the U.S. population ages, there is increasing need for data on effects of aging in healthy elderly individuals over age 80. This investigation compared swallowing ability 8 younger men between ages 21 and 29 older 80 94 during two swallows each 1 ml 10 liquid. Videofluoroscopic studies these were analyzed to confirm absence disorders. Biomechanical analysis swallow was completed, from which temporal, range motion, coordination characteristics oropharyngeal taken. Position larynx at rest,...
PURPOSE To determine if the clinical outcome of children with neuroblastoma (NB) is correlated degree tumor neovascularization and to assess relationship stage, N-myc copy number, histology angiogenesis. MATERIALS AND METHODS The vascularity primary untreated NB from 50 patients diagnosed at a single institution between 1984 1994 was evaluated. An image processor used analyze tissue area for each histologic slide tumor, vascular index (VI) calculated, where VI = total number vessels/mm2...
The oropharyngeal swallow of 10 patients with mild dysphagia at 3 weeks after a cerebrovascular accident (stroke), normal subjects, and 8 neurologically impaired moderate to severe was studied videofluorographically examine the effects 2 bolus temperatures (room temperature 33°F), volumes, viscosities on durations pharyngeal stage events frequency nature swallowing problems transit. Normal subjects exhibited significantly longer response times laryngeal elevation only for 1 ml cold liquid....
Objective: To examine the effects of hiatal hernia and lower esophageal sphincter (LES) pressure on competence gastroesophageal junction under conditions abrupt increases in intra-abdominal pressure. Design: Acute experiments. Setting: University-hospital-based gastroenterology practice. Participants: Sixteen asymptomatic volunteers 34 patients with endoscopic findings suggestive hernia. Intervention: A series eight provocative maneuvers entailing changes Measurements: Five radiographic...
Objectives. To assess the impact of total quality management (TQM) and organizational culture on a comprehensive set endpoints care for coronary artery bypass graft surgery (CABG) patients, including risk-adjusted adverse outcomes, clinical efficiency, patient satisfaction, functional health status, cost care. Methods. Prospective cohort study 3,045 eligible CABG patients from 16 hospitals using measures. Implementation TQM was measured by previously validated instrument based Baldridge...
This study examined the temporal effects of bolus volume on closure laryngeal vestibule at arytenoid to epiglottic base and mobile portion epiglottis, relationships between these levels airway cricopharyngeal opening for various volumes, mechanisms responsible two protection during deglutition. Closure progressed inferiorly superiorly all volumes. Duration increased systematically with volume, as did duration descent epiglottis below horizontal. occurred earlier in relation maximal elevation...
Clinical trials are recognized as the standard of care for cancer patient, and randomized, controlled trial represents most definitive method to determine effectiveness or ineffectiveness a treatment. However, less than 3% all eligible patients enter clinical trial. Of 437 physician members Illinois Cancer Center (ICC), 244 responded survey designed factors that present significant barrier entering on trials. Rigid protocol design was primary deterrent accrual, especially medical...
Thirty-one non-hemophilic patients with acquired antibodies to factor VIII were entered into a prospective, randomized, multi-institutional trial determine the safety and efficacy of prednisone (P), cyclophosphamide (C), or combination in treatment this disorder. Patients eligible if they had antibody demonstrated by Bethesda assay, not received these agents previously, gave informed consent. All treated initially P, 1 mg/kg, for 3 weeks. If persisted there was no rise activity, randomized...