A5014953513- Neurobiology of Language and Bilingualism
- Reading and Literacy Development
- Language Development and Disorders
- Action Observation and Synchronization
- EEG and Brain-Computer Interfaces
- Syntax, Semantics, Linguistic Variation
- Language, Metaphor, and Cognition
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Neural and Behavioral Psychology Studies
- Hearing Impairment and Communication
- Behavioral and Psychological Studies
- Spatial Neglect and Hemispheric Dysfunction
- Advanced Neuroimaging Techniques and Applications
- Second Language Acquisition and Learning
- Natural Language Processing Techniques
- Writing and Handwriting Education
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- Text Readability and Simplification
- Phonetics and Phonology Research
- Cerebrovascular and Carotid Artery Diseases
- Linguistics and Discourse Analysis
- S100 Proteins and Annexins
- Historical Linguistics and Language Studies
Northwestern University
2015-2025
Crossroads Community Hospital
2023
Center for Neuro-Oncology
2021
Northwestern University
2020
Alzheimer's Association
2016
Banner Alzheimer’s Institute
2016
Google (United States)
1986-2015
Communication Disorders Technology (United States)
2004-2014
Allergan (Ireland)
2014
Abbott (United States)
2011-2013
The frontal aslant tract is a direct pathway connecting Broca's region with the anterior cingulate and pre-supplementary motor area. This left lateralized in right-handed subjects, suggesting possible role language. However, there are no previous studies that have reported an involvement of this language disorders. In study we used diffusion tractography to define anatomy relation verbal fluency grammar impairment primary progressive aphasia. Thirty-five patients aphasia 29 control subjects...
The characteristics of early and mild disease in primary progressive aphasia are poorly understood. This report is based on 25 patients with quotients >85%, 13 whom were within 2 years symptom onset. Word-finding spelling deficits the most frequent initial signs. Diagnostic imaging was frequently negative consultations seldom reached a correct diagnosis. Functionality preserved, so that fit current criteria for single-domain cognitive impairment. One goal to determine whether recently...
Wernicke's aphasia is characterized by severe word and sentence comprehension impairments. The location of the underlying lesion site, known as area, remains controversial. Questions related to this controversy were addressed in 72 patients with primary progressive who collectively displayed a wide spectrum cortical atrophy sites language impairment patterns. Clinico-anatomical correlations explored at individual group levels. These analyses showed that neuronal loss temporoparietal areas,...
Eleven of 69 prospectively enrolled primary progressive aphasics were selected for this study because peak atrophy sites located predominantly or exclusively within the anterior left temporal lobe. Cortical volumes in these areas reduced to less than half control values, whereas average volume elsewhere hemisphere deviated from values by only 8%. Failure name objects emerged as most consistent and severe deficit. Naming errors attributed pure retrieval failure if object could not be named...
Abstract This study examined verb and argument structure production in 10 agrammatic aphasic non-brain-damaged subjects. Production of six types verbs was two conditions—a confrontation an elicited condition; arguments a sentence condition which each target with all possible arrangements. Results showed statistically significant differences between the subjects conditions, but no were found labelling conditions for either subject group. The subjects, however, produced obligatory one-place...
The syndrome of primary progressive aphasia (PPA) is diagnosed when a gradual failure word usage or comprehension emerges as the principal feature neurodegenerative disease.
This experiment examined the hypothesis that training production of syntactically complex sentences results in generalization to less have processes common with treated structures. Using a single subject experimental design, 4 individuals agrammatic aphasia were trained comprehend and produce filler-gap wh -movement, including, from least most complex, object-extracted who-questions, object clefts, objectrelative clausal embedding. Two participants received treatment first on structure ( who...
The effect of typicality category exemplars on naming was investigated using a single subject experimental design across participants and behaviors in 4 patients with fluent aphasia. Participants received semantic feature treatment to improve either typical or atypical items within categories, while generalization tested untrained the category. order trained counterbalanced participants. Results indicated that demonstrated intermediate items. However, no generalized examples. Furthermore,...
Primary progressive aphasia (PPA) is a clinical dementia syndrome characterized by decline in language function but relative sparing of other cognitive domains. There are three recognized PPA variants: agrammatic, semantic, and logopenic. Although each subtype the nature principal deficit, individual patients frequently display subtle impairments additional The present study investigated distribution atrophy related to performance specific domains (i.e., grammatical processing, semantic...
Verbs and sentences are often impaired in individuals with aphasia, differential impairment patterns associated different types of aphasia. With currently available test batteries, however, it is challenging to provide a comprehensive profile aphasic language impairments because they do not examine syntactically important properties verbs sentences.This study presents data derived from the Northwestern Assessment Sentences (NAVS; Thompson, 2011), new battery designed syntactic deficits The...
Primary progressive aphasia (PPA) is a clinical dementia syndrome with early symptoms of language dysfunction. Postmortem findings are varied and include Alzheimer disease frontotemporal lobar degeneration (FTLD), both tauopathies TAR DNA binding protein (TDP-43) proteinopathies. Clinical-pathological correlations in PPA complex but the presence profile agrammatism has high association tauopathy. Grammatical competence difficult to assess setting available methods. This article describes...
Abstract Neuroimaging and lesion studies suggest that processing of word classes, such as verbs nouns, is associated with distinct neural mechanisms. Such also subcategories within these broad class categories are differentially processed in the brain. Within verbs, argument structure provides one linguistic dimension distinguishes among verb exemplars, some requiring more complex entries than others. This study examined instantiation by complexity: one-, two-, three-argument verbs. Stimuli...
Purpose In this article, the authors encapsulate discussions of Language Work Group that took place as part Workshop in Plasticity/NeuroRehabilitation Research at University Florida April 2005. Method narrative review, they define neuroplasticity and review studies demonstrate neural changes associated with aphasia recovery treatment. The then summarize basic science evidence from animals, human cognition, computational neuroscience is relevant to treatment research. They turn literature...
Background: Classical aphasiology, based on the study of stroke sequelae, fuses speech fluency and grammatical ability. Nonfluent (Broca's) aphasia often is accompanied by agrammatism; whereas in fluent aphasias deficits are not typical. The assumption that a similar relationship exists primary progressive (PPA) has led to dichotomisation this syndrome into nonfluent subtypes. Aims: This compared elements production narrative individuals with PPA determine if they can be dissociated from one...
Abstract Background: Word class naming deficits are commonly seen in aphasia resulting from stroke (StrAph) and primary progressive (PPA), with differential production of nouns (objects) verbs (actions) found based on StrAph type or PPA variant for some individuals. However, studies to date have not compared word (or comprehension) ability the two aphasic disorders. In addition there no available measures testing deficits, which control important psycholinguistic variables across language...
BACKGROUND: Formal linguistic properties of sentences-both lexical, i.e., argument structure, and syntactic, movement-as well as what is known about normal disordered sentence processing production, were considered in the development Treatment Underlying Forms (TUF), a approach to treatment deficits patients with agrammatic aphasia. TUF focused on complex, non-canonical structures operates premise that training underlying, abstract, language will allow for effective generalisation untrained...